Resistance Patterns of Streptococcus pneumoniae from Children in Central Italy

Ronchetti, Maria Paola; Guglielmi, Francesco William; Latini, Laura; Merolla, Rocco; Lorusso, G.; Bajaksouzian, Saralee; Villa, Maria Pia; Catania, Salvatore; Jacobs, Michael; Ronchetti, R

doi:10.1007/pl00015024

Cited by 22 publications

(33 citation statements)

References 17 publications

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“…A further association with chloramphenicol resistance was present in strains belonging to serotype 6. This same pattern of multiresistance (erythromycin, tetracycline, and chloramphenicol, with or without resistance to TMP-SMZ, but with susceptibility to penicillin) was found to be characteristic of serotype 6 strains isolated from the nasopharynx of healthy children in central Italy [52]. Therefore, the diffusion of erythromycin resistance in Italy appears to be due to a combination of the spreading of a particular clone, as in the case of serotype 14 or multiresistant serotype 6, and the diffusion of different antibiotic resistance determinants among the isolates.…”

Section: Discussionmentioning

confidence: 70%

Antibiotic Susceptibility and Serotype Distribution ofStreptococcus pneumoniaeCausing Meningitis in Italy, 1997–1999

et al. 2000

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Because few data are available in Italy regarding antimicrobial susceptibility and serotype distribution of invasive Streptococcus pneumoniae strains, meningeal isolates collected at Italian hospitals during the years 1997-1999 were studied. The 12 most common serogroups, representing > 85% of the isolates, were 14, 23, 6, 4, 3, 9, 19, 8, 1, 12, 18, and 7 (in order of frequency). The serogroups identified in children < 5 years old were more limited in number: 80% are included in the 7-valent conjugate vaccines. Penicillin resistance was observed in 14 (9.5%) of 148 strains and increased from 5% in the first part of the study to 13% in the last part. Only 2 strains were fully penicillin resistant, and these belonged to serotype 9V. Thirty percent of the strains, mostly belonging to serogroups 14 or 6 and carrying either the ermB or the mef genes, were resistant to erythromycin.

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Section: Discussionmentioning

confidence: 70%

Antibiotic Susceptibility and Serotype Distribution ofStreptococcus pneumoniaeCausing Meningitis in Italy, 1997–1999

et al. 2000

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“…Resistance has also been linked to overuse of antibiotics and day care attendance [25,27]. In Italy, samples collected from nasopharyngeal swabs of 3-to 5-year-old children in day care centres or outpatient hospital clinics showed a high prevalence of penicillin-resistant pneumococci (14%), erythromycinresistant pneumococci (60%), and multiple antibioticresistant pneumococci (53%) [50].…”

Section: Antibiotic Resistancementioning

confidence: 99%

Pneumococcal disease in western Europe: burden of disease, antibiotic resistance and management

Cartwright

2002

Eur J Pediatr

132

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across Europe, pneumococcal infection is responsible for considerable morbidity and mortality, particularly in the very young and the elderly, groups whose members respond poorly to non-conjugated vaccines. The advent of new conjugated pneumococcal vaccines now offers an exciting opportunity in developed countries to reduce both the current burden of disease and the threat of rising antibiotic resistance. Rolling out the use of such vaccines across Europe must be accompanied by detailed ongoing surveillance in order to detect any changes that might occur in the pattern of pneumococcal serotypes.

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“…These organisms are responsible for most episodes of acute otitis media (4), and nasopharyngeal colonization precedes the development of otitis (10,11). Day care center (DCC) attendance has been reported as a major risk factor for increased rates of carriage of these respiratory bacterial pathogens (1), for increased incidence of upper respiratory tract infections (3), and for increased prevalence of antibiotic resistance, especially in S. pneumoniae (6,15,18).…”

mentioning

confidence: 99%

Nasopharyngeal Carriage of Potential Bacterial Pathogens Related to Day Care Attendance, with Special Reference to the Molecular Epidemiology of Haemophilus influenzae

Peerbooms

Engelen²,

Stokman³

et al. 2002

J Clin Microbiol

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Nasopharyngeal carriage of Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis was studied in 259 children attending day care centers (DCC) in Amsterdam, The Netherlands, and in 276 control children. The DCC children were sampled a second time after 4 weeks. Carriage rates for DCC children and controls were 58 and 37% for S. pneumoniae, 37 and 11% for H. influenzae, and 80 and 48% for M. catarrhalis, respectively. No increased antibiotic resistance rates were found in strains isolated from DCC children. All H. influenzae isolates were typed by random amplified polymorphic DNA (RAPD) analysis. Evidence for frequent transmission of H. influenzae strains within DCC was found. In the control group only two isolates (4%) displayed identical RAPD types versus 38% of strains from DCC children. Colonization with H. influenzae appeared to be short-lived in these children; more than half of the children harboring H. influenzae in the first sample were negative in the second sample, whereas most children still positive in the second sample had a different genotype than in the first sample. Of the newly acquired strains in the second sample, 40% were identical to a strain that had been found in a child in the same DCC in the first sample. DCC are to be considered epidemiological niches with a high potential for the spread of pathogenic microorganisms.

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Resistance Patterns of Streptococcus pneumoniae from Children in Central Italy

Cited by 22 publications

References 17 publications

Antibiotic Susceptibility and Serotype Distribution ofStreptococcus pneumoniaeCausing Meningitis in Italy, 1997–1999

Antibiotic Susceptibility and Serotype Distribution ofStreptococcus pneumoniaeCausing Meningitis in Italy, 1997–1999

Pneumococcal disease in western Europe: burden of disease, antibiotic resistance and management

Nasopharyngeal Carriage of Potential Bacterial Pathogens Related to Day Care Attendance, with Special Reference to the Molecular Epidemiology of Haemophilus influenzae

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