Resistance response to Arenicin derivatives in Escherichia coli

Editorial: Antimicrobial Peptides: Molecular Design, Structure-Function Relationship, and Biosynthesis Optimization

“…AMPs constitute the first line of innate defense against infection. These molecules are attractive drug candidates due to their multifactorial mechanism of action, low propensity to select for bacterial resistance, among other things (Hao et al, 2017 ; Wang et al, 2018 , 2022 ; Liu et al, 2021a ; Zheng et al, 2021 ). A reasonable equilibrium between antimicrobials and infectious pathogens is critical in order to control high resistance and high variation among pathogens, and can potentially be achieved by the appropriate use of AMPs, antibiotic and vaccines, as the iron triangle theory summarized in Figure 1 .…”

“… An iron triangle of health protection from AMPs, antibiotics and vaccines for maintaining a reasonable equilibrium among pathogens, antimicrobials and drug resistances is important and essential for one health management at safety level (Hao et al, 2017 ; Wang et al, 2018 , 2022 ; Liu et al, 2021a ; Zheng et al, 2021 ). …”

“…Over 3,300 kinds of AMPs have now been found in a wide range of biological sources, ranging from microbes, plants, to animals (Torres et al, 2022 ). These peptides may possess optimal properties for further drug development, including their ability to permeabilize and disrupt the bacterial membrane, capability of regulating the immune system and also broad-spectrum antibiofilm activity, and reduced propensity to select for bacterial resistance (de la Fuente-Núñez et al, 2012 , 2016 ; Yang et al, 2019 ; Wang et al, 2022 ). These advantages of AMPs over conventional antibiotics have attracted attention despite that their use have primarily been limited to topical infections due to their relative narrow druggability and lack of special unique protocols to assess pharmacodynamics (Liu et al, 2021a ; Ma et al, 2021 ; Dos Santos-Silva et al ).…”

In Vitro Modulation of Complement Activation by Therapeutically Prospective Analogues of the Marine Polychaeta Arenicin Peptides

“…Arenicins, as biologically active peptides, have attracted the attention of researchers. A number of works are devoted to obtaining modified analogues with altered functional activities [ 21 , 34 , 35 , 36 ]. Three previously described arenicin analogues, Ar-1[V8R] [ 22 ], ALP1 [ 24 ], and AA139 [ 25 ], became the subject of study in the present work.…”

Editorial: Community series in antimicrobial peptides: Molecular design, structure function relationship and biosynthesis optimization

“…In the first volume of this topic, we proposed a combinatorial approach involving AMPs, antimicrobials and vaccines, which would be instrumental for the prevention and treatment of human and animal diseases within the One Health framework ( Figure 1 ) (Wang et al, 2018 , 2019 ; Cardoso et al, 2019a ; Yang et al, 2019 ; Ma et al, 2021 ; Wu et al, 2021 ; Zheng et al, 2021 ; Hao et al, 2022 ). Compared to conventional antimicrobials, AMPs possess certain advantages such as high penetration and internalization, in some cases decreased likelihood of resistance emergence among bacterial pathogens, and lower probability of accumulation in tissues (Wang et al, 2019 , 2022 ; Aminov, 2022 ). Selective inhibition of bacterial pathogens without causing significant cytotoxic effects, is not only an essential requirement but also a critical challenge for the R&D of AMPs.…”