Resistance risk assessment of mefentrifluconazole in Corynespora cassiicola and the control of cucumber target spot by a two-way mixture of mefentrifluconazole and prochloraz

Peng, Qin; Li, Xiuhuan; Li, Guixiang; Hao, Xinchang; Liu, Xili

doi:10.1016/j.pestbp.2023.105719

Cited by 7 publications

(2 citation statements)

References 45 publications

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“…fructicola . The overexpression of CcCYP51A and CcCYP51B also was associated with mefentrifluconazole resistance in Corynespora cassiicola . Overexpression of cyp51A , AtrF , AfuMDR1 , and AfuMDR4 were associated with the acquired mefentrifluconazole resistance in Aspergillus fumigatus with hereditary stability .…”

Section: Discussionmentioning

confidence: 92%

“…29 The overexpression of CcCYP51A and CcCYP51B also was associated with mefentrifluconazole resistance in Corynespora cassiicola. 30 Overexpression of cyp51A, AtrF, Af uMDR1, and Af uMDR4 were associated with the acquired mefentrifluconazole resistance in Aspergillus fumigatus with hereditary stability. 31 This investigation discovered the L144F substitution in FpCYP51B in four mutants that exhibited resistance to mefentrifluconazole.…”

Section: Discussionmentioning

confidence: 99%

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Mefentrifluconazole-Resistant Risk and Resistance-Related Point Mutation in FpCYP51B of Fusarium pseudograminearum

Li,

Ru,

Zhang

et al. 2024

J. Agric. Food Chem.

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Mefentrifluconazole, a triazole fungicide, exhibits remarkable efficacy in combating Fusarium spp. The mean EC50 value of mefentrifluconazole against 124 isolates of Fusarium pseudograminearum was determined to be 1.06 μg/mL in this study. Fungicide taming produced five mefentrifluconazole-resistant mutants with resistance factors ranging from 19.21 to 111.34. Compared to the original parental isolates, the fitness of three resistant mutants was much lower, while the remaining two mutants displayed enhanced survival fitness. There was evidence of positive cross-resistance between tebuconazole and mefentrifluconazole. Mefentrifluconazole resistance in F. pseudograminearum can be conferred by FpCYP51BL144F, which was identified in four mutants according to molecular docking and site-directed transformation experiments. Overexpression of FpCYP51s was also detected in the resistant mutants. In conclusion, mefentrifluconazole has a low-to-medium resistance risk in F. pseudograminearum, and the L144F mutation in FpCYP51B and the increased expression level of FpCYP51s may be responsible for mefentrifluconazole resistance in F. pseudograminearum.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Mefentrifluconazole-Resistant Risk and Resistance-Related Point Mutation in FpCYP51B of Fusarium pseudograminearum

Li,

Ru,

Zhang

et al. 2024

J. Agric. Food Chem.

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Resistance risk assessment of Rhizoctonia solani to four fungicides

Ou,

Hu,

et al. 2024

Pest Management Science

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BACKGROUNDHexaconazole, thifluzamide, difenoconazole and azoxystrobin are widely used fungicides for the control of Rhizoctonia solani in China. However, few studies have assessed the sensitivity and resistance risk of R. solani to these four fungicides.RESULTSThe sensitivities of 126 R. solani isolates to hexaconazole, thifluzamide, difenoconazole and azoxystrobin were determined, with average half maximal effective concentration (EC50) values of 0.0386, 0.0659, 0.663 and 1.508 μg mL−1, respectively. Field resistance monitoring of the four fungicides showed that the three isolates had moderate resistance to difenoconazole. Resistant mutants to the four fungicides were obtained by fungicide adaptation, and resistance could be stably inherited by most mutants. Compared with those of the parent isolates, the biological characteristics of hexaconazole‐resistant mutants exhibited enhanced or similar compound fitness index (CFI), whereas most of the other mutants displayed reduced or comparable CFI. There was evidence of positive cross‐resistance between hexaconazole and difenoconazole. In the presence of fungicides, the expression of the CYP51 genes in hexaconazole‐ and difenoconazole‐resistant mutants significantly increased, the expression of SDH genes in thifluzamide‐resistant mutants significantly decreased, and the expression of the Cyt b gene in azoxystrobin‐resistant mutants did not significantly change.CONCLUSIONBased on these data, we speculated that R. solani had a low‐to‐medium resistance risk to four fungicides. The change of target gene expression may be one of the reasons for fungicide resistance in R. solani. This study provides a theoretical basis for monitoring resistance emergence and developing resistance management strategies to control R. solani. © 2024 Society of Chemical Industry.

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Overexpression of the CcCYP51A and CcCYP51B genes confer Corynespora cassiicola resistance to prochloraz

Deng,

Wang,

Zhang

et al. 2024

Pesticide Biochemistry and Physiology

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Resistance risk assessment of mefentrifluconazole in Corynespora cassiicola and the control of cucumber target spot by a two-way mixture of mefentrifluconazole and prochloraz

Cited by 7 publications

References 45 publications

Mefentrifluconazole-Resistant Risk and Resistance-Related Point Mutation in FpCYP51B of Fusarium pseudograminearum

Mefentrifluconazole-Resistant Risk and Resistance-Related Point Mutation in FpCYP51B of Fusarium pseudograminearum

Resistance risk assessment of Rhizoctonia solani to four fungicides

Overexpression of the CcCYP51A and CcCYP51B genes confer Corynespora cassiicola resistance to prochloraz

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