Resistance to adenovirus infection after administration of Bordetella pertussis vaccine in mice

Winters, Alvin L.; Baggett, David W.; Benjamin, William R.; Brown, H K; Klein, Thomas

doi:10.1128/iai.47.3.587-591.1985

Cited by 8 publications

(1 citation statement)

References 18 publications

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“…Though, the exact components and mechanisms by which such suggested undesirable modulatory effects may occur as well as the degree of implication of pertussis vaccine alone in such consequences are unknown. To note, earlier studies in mice reported a beneficial antiviral role of pertussis vaccine against several viruses including adenovirus and vesicular stomatitis virus [72] , [73] , [74] . However, using a mouse model, a report showed that DTP administration increases mortality after challenge with the respiratory syncytial virus (RSV) and it was suggested that detoxified pertussis toxin may be involved in this effect [75] .…”

Section: Concernsmentioning

confidence: 99%

COVID-19 in children: Could pertussis vaccine play the protective role?

et al. 2020

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While COVID-19 continues to spread across the globe, diligent efforts are made to understand its attributes and dynamics to help develop treatment and prevention measures. The paradox pertaining to children being the least affected by severe illness poses exciting opportunities to investigate potential protective factors. In this paper, we propose that childhood vaccination against pertussis (whooping cough) might play a non-specific protective role against COVID-19 through heterologous adaptive responses in this young population. Pertussis is a vaccine-preventable infectious disease of the respiratory tract and it shares many similarities with COVID-19 including transmission and clinical features. Although pertussis is caused by a bacterium ( Bordetella pertussis ) while COVID-19 is a viral infection (SARS-CoV-2), previous data showed that cross-reactivity and heterologous adaptive responses can be seen with unrelated agents of highly divergent groups, such as between bacteria and viruses. While we build the arguments of this hypothesis on theoretical and previous empirical evidence, we also outline suggested lines of research from different fields to test its credibility. Besides, we highlight some concerns that may arise when attempting to consider such an approach as a potential public health preventive intervention against COVID-19.

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Section: Concernsmentioning

confidence: 99%

COVID-19 in children: Could pertussis vaccine play the protective role?

et al. 2020

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Mouse Adenovirus Type-1 Replication Is Restricted to Vascular Endothelium in the CNS of Susceptible Strains of Mice

et al. 1998

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Previous studies have shown that mouse adenovirus type-1 (MAV-1) caused a fatal hemorrhagic encephalitis in certain strains of mice. C57BI/6 mice exhibited 100% mortality when given as little 10(3) plaque-forming units (PFU) of MAV, in contrast to BALB/c mice which were resistant to as many as 10(6) PFU. Susceptible animals died with a flaccid paralysis on the 3rd or 4th day after inoculation. The brains and spinal cords of these animals displayed numerous petechial hemorrhages that were found in virtually all areas of the brain, but were more numerous in white matter. In this paper, immunohistochemistry and electron microscopy were used to identify the viral target of replication within the CNS of susceptible mice. These studies showed that the CNS vascular endothelial cell was the primary site of viral replication within the CNS of mice infected with MAV-1. Characterization of cytokine mRNA levels and disease course in immunodeficient mice revealed that the host immune response played little, if any, role in the pathogenesis of MAV-1 disease in susceptible mice and was not responsible for the resistance of BALB/c mice. These results support the conclusion that disease course and outcome in susceptible and resistant strains of mice were determined primarily by the ability of the virus to replicate within the CNS vascular endothelium.

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