Resistance to antibiotics of bacteria in tropical countries

Raoult, Didier

doi:10.1016/s2542-5196(19)30092-0

The Lancet Planetary Health

2019

DOI: 10.1016/s2542-5196(19)30092-0

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Resistance to antibiotics of bacteria in tropical countries

Didier Raoult

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Cited by 2 publications

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Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal

Baron

Mediannikov

Abdallah

et al. 2021

Antimicrob Agents Chemother

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Antibiotic resistance genes exist naturally in various environments far from human usage. Here, we investigated multidrug-resistant Klebsiella pneumoniae, a common pathogen of chimpanzees and humans. We screened antibiotic-resistant K. pneumoniae from 48 chimpanzee stools and 38 termite mounds (N=415 samples) collected in protected areas in Senegal. The microsatellite method was used to identify chimpanzee individuals (N=13). Whole genome sequencing was performed on K. pneumoniae complex isolates to identify antibiotic-resistant genes and characterize clones. We found a high prevalence of carbapenem-resistant K. pneumoniae among chimpanzee isolates (18/48 samples from 7/13 individuals) and ceftriaxone resistance among both chimpanzee individuals (19/48) and termite mounds (7/415 termites and 3/38 termite mounds). The bla OXA-48 and the bla KPC-2 genes were carried by international pOXA-48 and pKPC-2 plasmids respectively. The ESBL plasmid carried bla CTX-M-15 , bla TEM-1B and bla OXA-1 genes. Genome sequencing of 56 isolates identified two major clones associated with hospital-acquired infections of K. pneumoniae (ST307 and ST147) in chimpanzees and termites, suggesting circulation of strains between the two species, as chimpanzees feed on termites. The source and selection pressure of these clones in this environment need to be explored.

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Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal

Baron

Mediannikov

Abdallah

et al. 2021

Antimicrob Agents Chemother

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Occurrence of antimicrobial-resistant Escherichia coli in sewage treatment plants of South India

Praveenkumarreddy

Akiba

Guruge

et al. 2020

Journal of Water, Sanitation and Hygiene for Development

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Antibiotics received by sewage treatment plants may be the causative factor in spreading antibiotic resistance bacteria in the aquatic environment. The current study investigates the distribution of antimicrobial-resistant Escherichia coli (E. coli) in four sewage treatment plants (STPs) in South India receiving hospital and domestic wastewater in different proportions. A total of 221 E. coli isolates were checked for antimicrobial resistance against 16 antimicrobials. Among the antimicrobials tested, ampicillin (AMP) and cefazolin (CFZ) showed resistance between 20% and 90%, nalidixic acid (NAL) and ciprofloxacin (CIP) showed resistance between 15% and 75% and chloramphenicol (CHL) showed resistance between 2% and 20%. Based on the observations, there is no significant difference between the wastewater inlet and outlet, suggesting that treatment process was not effective in reducing the resistance. In conclusion, the trends of antimicrobial resistance pattern show that the levels of resistance were slightly higher in hospital wastewater than domestic wastewater.

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Resistance to antibiotics of bacteria in tropical countries

Cited by 2 publications

References 11 publications

Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal

Multidrug-Resistant Klebsiella pneumoniae Clones from Wild Chimpanzees and Termites in Senegal

Occurrence of antimicrobial-resistant Escherichia coli in sewage treatment plants of South India

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