Resistance to Ketosis in Obese Subjects

Kekwick, A.; Pawan, G. L. S.; Chalmers, T. M.

doi:10.1016/s0140-6736(59)91737-4

Cited by 146 publications

(26 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, in healthy children, a significant exponential decay association was found between %IBW and fasting breath ACET, indicating that children heavier than their IBW have a lower fasting breath ACET. This finding is in agreement with earlier observations that heavier people are more resistant to developing ketosis (29).…”

Section: Discussionsupporting

confidence: 94%

Epilepsy and the Ketogenic Diet: Assessment of Ketosis in Children Using Breath Acetone

Musa-Veloso

2002

Pediatric Research

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 94%

Epilepsy and the Ketogenic Diet: Assessment of Ketosis in Children Using Breath Acetone

Musa-Veloso

2002

Pediatric Research

View full text Add to dashboard Cite

“…Conversely, the obese rely less on protein catabolism as a source of glucose carbon. The ability of fat individuals to spare protein breakdown during acute starvation has previously been noted (25). The increased availability of glycerol to supply glucose is though to be at least partially responsible for this.…”

Section: Introductionmentioning

confidence: 92%

Glycerol turnover and oxidation in man

Bortz¹,

Paul²,

Haff³

et al. 1972

J. Clin. Invest.

212

View full text Add to dashboard Cite

A BST RA CT The oxidation and turnover of plasma glycerol has been studied in lean and obese, fed and starving man by means of a long-term infusion of glycerol-"4C, and the participation of glycerol in gluconeogenesis has been determined.Under none of the experimental conditions did glycerol contribute more than 10% of the total respiratory C02. Glycerol turnover in fed lean subjects was 106 mmoles/min. Glycerol levels and turnover were higher in the obese subjects and with all subjects after starvation. There was a direct correlation between plasma levels and turnover values for which a regression equation was derived: y = 1556 x + 33.1, when y= turnover in micromoles per minute and x = glycerol level in micromoles per milliliter.Whereas a. direct relation was established between glycerol and FFA levels, the FFA/glycerol turnover ratio was 4.7: 1 in the lean group indicating incomplete hydrolysis of adipose tissue triglycerides.

show abstract

“…29 A higher proportion of glycerol and protein converted into glucose has been reported in obese subjects during fasting periods 29 and the ability of obese individuals to spare protein breakdown during acute starvation has previously been reported. 30 To interpret the evolution of the plasma glycerol concentration, during and after ANP infusion, it can be proposed that when lipolysis is increased under ANP infusion, a rapid uptake of glycerol for neoglucogenesis occurring in the liver contributes to the decrease in its plasma level. This effect is stronger in obese subjects submitted to LCD containing a high proportion of protein.…”

Section: International Journal Of Obesitymentioning

confidence: 99%

Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women

et al. 2002

View full text Add to dashboard Cite

OBJECTIVE:We recently demonstrated that natriuretic peptides (NP) are involved in a pathway inducing lipolysis in human adipose tissue. Atrial NP (ANP) and brain NP (BNP) operate via a cGMP-dependent pathway which does not involve phosphodiesterase-3B inhibition or cAMP. The study was performed to evaluate the effect of ANP on lipid mobilization in obese women and secondly to examine the possible effect of a low-calorie diet (LCD) on the lipolytic response of subcutaneous abdominal fat cells to NP and on the lipid mobilization induced by ANP infusion (1 mg=m 2 min for 60 min). SUBJECTS: Ten obese women from 40.5 AE 3.4 y old were selected for this study. Their body weight was 96.4 AE 5.7 kg and their BMI was 35.3 AE 1.7 kg=m 2 . They received a 2.5 -2.9 MJ=day formula diet for 28 days. DESIGN: Before and during the LCD, an adipose tissue biospy was performed for in vitro studies and, moreover, ANP was perfused i.v. to evaluate its lipid mobilizing action in toto and in situ in subcutaneous abdominal adipose tissue (SCAAT) using microdialysis. RESULTS: The lipolytic effects of isoproterenol, ANP, BNP and bromo-cGMP (an analogue of cGMP) on fat cells increased by about 80 -100% during LCD. The lipid mobilization during i.v. ANP infusion, assessed by plasma non-esterified fatty acids (NEFA) increase was enhanced during the LCD. However, during LCD, ANP infusion induced a biphasic effect on glycerol concentration in plasma and interstitial fluid of SCAAT; a significant increase was observed in glycerol levels during the first 30 min infusion period, followed by a steady decrease. The concentration of glycerol was lower during the post-infusion period than during the baseline period. This effect was stronger in obese subjects submitted to the LCD with a low-carbohydrate composition. Other plasma parameters were weakly increased (noradrenaline) or not modified (insulin, glucose) by ANP infusion and no difference was found before and during LCD treatment.CONCLUSION: The present study shows that NP are powerful lipolytic agents in subcutaneous fat cells and that both isoproterenol-and NP-induced lipolysis increase during LCD, in obese women. These changes seem to be associated with an improvement of the lipolytic pathway at a post-receptor level. Moreover, i.v. administration of ANP induced a lipid mobilizing effect which was enhanced by a LCD in these objects.

show abstract

Resistance to Ketosis in Obese Subjects

Cited by 146 publications

References 5 publications

Epilepsy and the Ketogenic Diet: Assessment of Ketosis in Children Using Breath Acetone

Epilepsy and the Ketogenic Diet: Assessment of Ketosis in Children Using Breath Acetone

Glycerol turnover and oxidation in man

Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women

Contact Info

Product

Resources

About