Resistance to mycobacterial infection: A pattern of early immune responses leads to a better control of pulmonary infection in C57BL/6 compared with BALB/c mice

CD11c+ CD103+ cells of Mycobacterium tuberculosis‐infected C57BL/6 but not of BALB/c mice induce a high frequency of interferon‐γ‐ or interleukin‐17‐producing CD4+ cells

“…showed that CD4 + lymphocytes from ovalbumin‐specific T‐cell receptor transgenic mice (DO11.10) co‐cultured with lung CD103 + dendritic cells secreted significant levels of IFN‐ γ and IL‐17, whereas in the presence of lung CD11b + dendritic cells there was preferential IL‐4, IL‐6 and IL‐10 production. Consequently, the higher number of CD103 + dendritic cells in the lungs of infected C57BL/6 mice may represent a key factor for the higher magnitude of adaptive response (based on IFN‐ γ and IL‐17 production) previously reported by us and other groups . Indeed, we confirmed this hypothesis when we showed that lung CD103 + dendritic cells from M. tuberculosis ‐infected C57BL/6 mice, but not from BALB/c mice, induced a higher frequency of IFN‐ γ ‐secreting or IL‐17‐secreting CD4 + cells.…”

“…The genetic background of an animal is important for the generation of an immune response that can increase either the resistance or the susceptibility to M. tuberculosis infection. Although C57BL/6 mice are resistant and BALB/c mice have an intermediate resistance to M. tuberculosis infection, the former generate a stronger Th1 immune response, while BALB/c mice generate a Th2‐driven immune response . Previous study by our group has shown that C57BL/6 mice exhibit higher IFN‐ γ and IL‐17 production, lower IL‐10 production, and greater suppressive function of regulatory T cells followed by lower lung bacterial growth when compared with BALB/c mice .…”

“…C57BL/6 and BALB/c mice are considered more resistant to M. tuberculosis infection than DBA/2, CBA and C3H strains . However, C57BL/6 mice generate a robust cellular immune response characterized by interferon‐ γ (IFN‐ γ ) production compared with the lower magnitude of cellular immune response observed in BALB/c mice . In previous work, our group established that M. tuberculosis ‐infected C57BL/6 mice produce higher levels of IFN‐ γ and interleukin‐17 (IL‐17) and lower levels of IL‐10 along with a lower suppressor activity of regulatory T cells compared with infected BALB/c mice.…”

PPE38 Protein of Mycobacterium tuberculosis Inhibits Macrophage MHC Class I Expression and Dampens CD8+ T Cell Responses

“…In general, C57BL/6 mice are relatively more resistant to MTB infection than BALB/c mice (Flynn et al, 1995; Chackerian and Behar, 2003; Arko-Mensah et al, 2009; Sergio et al, 2015). In the current study, we have observed that the MTB PPE38 protein only enhanced the survival of M. smegmatis in C57BL/6 mice instead of BALB/c mice.…”

Adherent Properties and Macrophage Activation Ability of 3 Strains of Lactic Acid Bacteria

“…When pathogens cross the epithelial barrier, macrophages are induced to perform certain functions, including phagocytosis and production of cytokines, such as TNF‐α and IL‐12 (Gusella and others 1993; Mennechet and others 2002; Paturi and others 2008). In particular, TNF‐α production augments antimicrobial systems by NO‐dependent killing pathways that act against pathogen infections (Nathan 1992; Kirby and others 2002; Sterns and others 2005; Arko‐Mensah and others 2009). In our study of macrophage activation, intact LAB was necessary to induce TNF‐α secretion from active macrophages.…”