Resistance to Parvovirus B19 Infection Due to Lack of Virus Receptor (Erythrocyte P Antigen)

Brown, Kevin E.; Hibbs, Jonathan R.; Gallinella, Giorgio; Anderson, Stacie M.; Lehman, E. Dale; McCarthy, Peggy; Young, Neal S.

doi:10.1056/nejm199404283301704

Cited by 321 publications

(175 citation statements)

References 23 publications

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“…It is well known that B19 can only infect the cells that have the proper receptors to which the virus can attach. Human blood group P antigen has been confirmed to be the indispensable cellular receptor for B19 infection (Brown et al, 1994). Human thyroid follicle epithelia have been shown to have globoside (Bouchon et al, 1985).…”

Section: Discussionmentioning

confidence: 99%

Detection of human parvovirus B19 in papillary thyroid carcinoma

et al. 2008

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To evaluate whether parvovirus B19, a common human pathogen, was also involved in papillary thyroid carcinoma (PTC), 112 paraffin-embedded thyroid specimens of benign nodules, papillary, medullary and follicular carcinomas, and normal controls were examined for B19 DNA and capsid protein by nested PCR, in situ hybridisation (ISH) and immunohistochemistry (IHC). The expression of the nuclear factor-kB (NF-kB) was investigated by IHC. The results showed B19 DNA commonly exists in human thyroid tissues; however, there were significant differences between PTC group and normal controls, and between PTC and nonneoplastic adjacent tissues (Po0.001). The presence of viral DNA in PTC neoplastic epithelium was confirmed by laser-capture microdissection and sequencing of nested PCR products. B19 capsid protein in PTC group was significantly higher than that of all the control groups and nonneoplastic adjacent tissues (Pp0.001). Compared with control groups, the activation of NF-kB in PTC group was significantly increased (Pp0.02), except for medullary carcinomas, and the activation of NF-kB was correlated with the viral protein presence (P ¼ 0.002). Moreover, NF-kB was colocalised with B19 DNA in the neoplastic epithelium of PTC by double staining of IHC and ISH. These results indicate for the first time a possible role of B19 in pathogenesis of PTC.

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Section: Discussionmentioning

confidence: 99%

Detection of human parvovirus B19 in papillary thyroid carcinoma

et al. 2008

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“…[6] Parvovirus replicates exclusively in erythroid progenitor cells that have the P antigen receptor. [7] Patients with hemolytic anemias, including sickle cell anemia, thalassemia, pyruvate kinase deficiency, autoimmune hemolytic anemia, spherocytosis, pyropoikilocytosis, and elliptocytosis have all been reported to have erythroblastopenic crisis in conjunction with parvovirus infections. [8] In general, crisis caused by the virus is self-limiting and resolve in one to two weeks.…”

Section: Discussionmentioning

confidence: 99%

Pure Red Cell Aplasia in a Case of Severe Hookworm Infestation: Superadded Parvovirus B19 Infection Causing Diagnostic Confusion

Ghosh¹

2016

jmscr

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“…Viruses have also been shown to have interactions with blood group antigens. In terms of the P blood group system, Parvovirus B19 utilizes the P antigen as its receptor to infect cells, and individuals with the p phenotype lacking P are resistant to the virus (Brown et al, 1994). More recently, the P1PK and GLOB blood group system antigens, specifically, P k , has been implicated as having a role in HIV infection (Branch, 2010)(see below).…”

Section: Relationship To Diseasementioning

confidence: 99%