Resistance to penicillin among theStreptococcus pneumoniaein Turkey

Yurdakul, Ahmet Selim; Çalişir, Haluk C.; Atasever, Melike; Ordulu, L.; Öğretensoy, Mihriban

doi:10.1183/09031936.01.00237801

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…In this study, penicillin resistance was slightly increased (12%) compared to previous values found in Turkey [7][8][9][10]. A high prevalence of resistance to macrolides was observed: 20% to azithromycin and 18% to clarithromycin.…”

Section: Discussionmentioning

confidence: 49%

Comparative Activities of β-Lactam Antibiotics and Quinolones for Invasive Streptococcus pneumoniae Isolates

Öncü

Punar²,

Eraksoy³

2004

Chemotherapy

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Background: Streptococcus pneumoniae is a leading pathogen causing pneumonia, meningitis, otitis media, bacteremia and sinusitis resulting in significant morbidity and mortality. We examined in vitro activities of five quinolones in comparison with other antibiotics against 85 invasive pneumococcal isolates. Methods: Minimal inhibitory concentrations (MICs) of penicillin G, cefuroxime, azithromycin, clarithromycin, trimethoprim-sulfamethoxazole (SXT), ciprofloxacin, ofloxacin, levofloxacin, trovafloxacin and gemifloxacin were determined using a broth microdilution method. Results: The overall rates of resistance to penicillin (46%), cefuroxime (20%), azithromycin (20%), clarithromycin (18%) and SXT (46%) were considerable. Among all of the isolates, 9 isolates (11%) were highly resistant (MIC ≧2 mg/l) and 30 isolates (35%) had intermediate resistance (MIC 0.12– 1.0 mg/l). Of the quinolones gemifloxacin and trovafloxacin had the highest activity. The penicillin resistance status of the isolates did not have any effect on the resistance pattern of new quinolones. Conclusion: The new quinolones show great potential in the treatment of invasive infections caused by both penicillin-susceptible and penicillin-resistant pneumococci.

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Section: Discussionmentioning

confidence: 49%

Comparative Activities of β-Lactam Antibiotics and Quinolones for Invasive Streptococcus pneumoniae Isolates

Öncü

Punar²,

Eraksoy³

2004

Chemotherapy

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“…In the study of Duman et al (13), Streptococcus pneumoniae strains were isolated in a three-year period and penicillin resistance was found at a rate of 18.2%. In various publications in our country, Streptococcus pneumoniae penicillin resistance has been reported as 3-38% (15,16). In the study performed by Sümer et al (17), no agent could be isolated in 283 (68.5%) of the CSF samples, while Coagulase-negative staphylococci (CNS) (64.6%) took the first place in 130 CSF cultures.…”

Section: Discussionmentioning

confidence: 97%

Menejit Ön tanısıyla Başvuran Hastalarda Beyin Omirilik Sıvı Sonuçlarının Değerlendirilmesi

Özkan

Çaycı

2023

Sağlık Bilimlerinde Değer

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Aim: It was aimed to determine the microorganisms and antibiotic susceptibilities obtained from cerebrospinal fluid samples (CSF). Material and Methods: CSF samples of 138 patients who admitted with a prediagnosis of meningitis to Ondokuz Mayıs University Pediatric Emergency Department between 01/01/2021-01/01/2022 was included. CSF cultures, identification of bacteria and their antibiotic susceptibilities were evaluated by VITEK 2 (bioMeriux, France) automated identification system. If the growth was detected by blood culture system, the specimen was cultivated onto the 5% blood agar, Eosin Methylene Blue agar and chocolate agar. Also, CSF samples were studied for both viral and bacterial agents with the Smart Cycler (Cepheid, USA) device working with Real-Time PCR method. In this system, Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Cytomegalovirus, Herpes simplex type-1, Herpes simplex type-2, Human herpes virus type-6 (HHV-6), Varicella zoster virus and Epstein Barr virus agents were detected. Results: Of the 138 CSF samples, 50,88% were male and 49,12% were female. The mean age of the patients was 36 ± 55 months. Bacterial agents were detected in 18 (13,8%) of the CSF samples and viral agents in 12 (9,2%) samples. Staphylococcus epidermidis (64.6%), Staphylococcus aureus (7.7%) and Streptococcus pneumonia (6.9%) took the first three places in bacterial agents. Among the viral agents, HHV-6 was the most common followed by Enteroviruses. Conclusion: It has been observed that the profiles and resistance status of microorganisms frequently seen in CSF have changed over the years.

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Nosocomial pneumonia: emerging concepts in diagnosis, management, and prophylaxis

Craven¹,

Rosa²,

Thornton

2002

Current Opinion in Critical Care

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Nosocomial pneumonia is a dynamic disease with multiple etiologic agents and a changing natural history. The highest attack rates and mortality occur in patients with ventilator-associated pneumonia. Diagnosis of nosocomial pneumonia is often made by clinical criteria that are sensitive but lack specificity. The use of quantitative endotracheal aspirates or bronchoscopy with bronchoalveolar lavage and protected specimen brush clearly improve diagnostic specificity and outcome in patients who are mechanically ventilated. The rapid spread of multidrug-resistant, spp, and has made initial empiric therapy more difficult. Management principles include the use of techniques for more accurate diagnosis and early antimicrobial therapy with appropriate agents along with careful analysis of culture results, clinical response, and potential complications of pneumonia and therapy. Strategies for prophylaxis are of critical importance for risk reduction, improvement in patient outcome, and reduction of hospital costs.

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Resistance to penicillin among theStreptococcus pneumoniaein Turkey

Cited by 4 publications

References 5 publications

Comparative Activities of β-Lactam Antibiotics and Quinolones for Invasive <i>Streptococcus pneumoniae</i> Isolates

Comparative Activities of β-Lactam Antibiotics and Quinolones for Invasive <i>Streptococcus pneumoniae</i> Isolates

Menejit Ön tanısıyla Başvuran Hastalarda Beyin Omirilik Sıvı Sonuçlarının Değerlendirilmesi

Nosocomial pneumonia: emerging concepts in diagnosis, management, and prophylaxis

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