Resistance to Pyrethrins and to Pyrethrins - Piperonyl Butoxide in a Wild Strain of Musca domestica L. in Sweden

Davies, Matthew; Keiding, J.; Hofsten, C. G. Von

doi:10.1038/1821816a0

Cited by 26 publications

(7 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…Although PBO-synergized pyrethrum and pyrethroid insecticides have been tested and used in the field since 1950 [12,27,41], insect resistance to PBO-synergized insecticides and insecticide products is seldom reported [27,28]. Davies [27,28]. Many studies found that preexposure of highly pyrethroid-resistant Aedes, Anopheles and Culex mosquitoes to a synergist such as PBO, DEF, TPP or DEM did not fully restore the mosquitoes' mortality [36,[42][43][44][45][46][47], however, most of these studies used the synergist to infer the mechanisms behind resistance without examining the mechanisms themselves, i.e., enzyme activity before and after synergist exposure.…”

Section: Discussionmentioning

confidence: 99%

“…Laboratory selection studies found that the addition of PBO slowed the development of pyrethroid insecticide resistance in Aedes aegypti and Anopheles stephensi mosquitoes and agricultural insect pest white flies; however, insecticide-resistant mosquitoes quickly developed resistance to PBO-synergized insecticides [24][25][26]. A study in Musca domestica houseflies found that the flies developed resistance to PBO-synergized pyrethrins after just one year of continuous field applications of PBO-synergized pyrethrins [27]. A recent study in Mozambique found that highly insecticide-resistant Anopheles funestus was also resistant to PBO-LLIN [28].…”

Section: Introductionmentioning

confidence: 99%

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Emerging mosquito resistance to piperonyl butoxide-synergized pyrethroid insecticide and its mechanism

Zhou

Jeang

et al. 2021

Preprint

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Piperonyl butoxide (PBO)-synergized pyrethroid products are widely available for the control of pyrethroid-resistant mosquitoes. To date, no study has formally examined mosquito resistance to PBO-synergized insecticides. We used Culex quinquefasciatus as a model mosquito examined the insecticide resistance mechanisms of mosquitoes to PBO-synergized pyrethroid using modified World Health Organization tube bioassays and biochemical analysis of metabolic enzyme expressions prior- and post-PBO exposure. We measured mosquito mortalities and metabolic enzyme expressions in mosquitoes with/without pre-exposure to different PBO concentrations and exposure durations. We found that field Culex quinquefasciatus mosquitoes were resistant to all insecticides tested, including PBO-synergized pyrethroids (mortality ranged from 3.7±4.7% to 66.7±7.7%), except malathion. Field mosquitoes had elevated levels of carboxylesterase (COE, 3.8-fold) and monooxygenase (P450, 2.1-fold) but not glutathione S-transferase (GST) compared to susceptible mosquitoes. When the field mosquitoes were pre-exposed to 4% PBO, the 50% lethal concentration of deltamethrin was reduced from 0.22% to 0.10%, compare to 0.02% for susceptible mosquitoes. Knockdown resistance gene mutation (L1014F) rate was 62% in field mosquitoes. PBO pre-exposure suppressed P450 enzyme expression levels by 25~34%, GST by 11%, and had no impact on COE enzyme expression. Even with the optimal PBO concentration and exposure duration, field mosquitoes had significantly higher P450 enzyme expression levels after PBO exposure compared to laboratory controls. These results demonstrate that PBO alone may not be enough to control highly pyrethroid resistant mosquitoes due to the multiple resistance mechanisms. Mosquito resistance to PBO-synergized insecticide should be closely monitored.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Emerging mosquito resistance to piperonyl butoxide-synergized pyrethroid insecticide and its mechanism

Zhou

Jeang

et al. 2021

Preprint

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“…Table 3 There are genetic indications, in addition to electrophysiological data, showing pyrethroids target the VGSC. In the 1950s houseflies were initially documented in pyrethroid, or knockdown-resistant (KDR) Busvine (1951), Davies et al (1958). The flying family's kdr and superkdr traits have shown that the VGSC VSsc1 housefly was directly responsible for their resistance to pyrethroids Williamson et al (1993).…”

Section: Mechanism Neurotoxicity Of Pyrethroids 51 Effect On Insects ...mentioning

confidence: 99%

A Comprehensive Review on Neurotoxicity of Pyrethroids

Ahmed

Athar

2023

Int. J. Res. Granthaalayah

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Pyrethroids are synthetic derivations of natural pyrethrins from the factory Chrysanthemum cinerariaefolium. They comprise esters of chrysanthemum acid (ethyl, 2-dimethyl-3-(1-isobutenyl) cyclopropane-1-carboxylate) and halogenated derivations of their acids and alcohols. Pyrethroids are generally used in menage diseases and companion beast ectoparasite control products, and their limited use in the home terrain raises the trouble of exposure and adverse goods in the general population for humans and advanced creatures. Exploration with a wide range of pyrethroids has indicated that the choreothetosis-expectoration (CS) pattern frequently occurs as substances like deltamethrin, cypermethrin, and fenvalerate, which have the mode T- cyano-3-phenoxybenzylalcohol. General, extensively used bracket of Pyrethroid composites are determined grounded upon the symptomology of nonentity goods noted in neurophysiological tests. Numerous lines of substantiation indicate that the voltage sensitive sodium channel for both insects is the one main molecular destination for all pyrethroids and DDT analogues. In biophysical and biochemical examinations, the changes in sodium channel functioning are nearly connected to the impact of these substances on complete neurons. The pyrethroid sodium channel discovery point demonstrates the strict stereo particularity anticipated by in vivo nonentity neurotoxicity estimates. Composites of type I and type II have qualitative goods on currents of the sodium channel tail, divergent impact on complete neurons and differing goods on muscle excitability of the invertebrate shell. Knowledge of the molecular events bolstering pyrethroid neurotoxicity is directly applicable to determining whether this large and important class of diseases constitutes a single “common medium” group or multiple groups for the purposes of cumulative trouble assessment.

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“…Pyrethroid resistant, or knockdown-resistant (kdr), houseflies were first reported in the 1950s [62,63]. Genetic mapping of the kdr and super-kdr trait in houseflies revealed that pyrethroid resistance was tightly linked to the housefly VGSC gene, Vssc1 [64].…”

Section: Pyrethroid Effects On Insect Voltage-gated Sodium Channelsmentioning

confidence: 99%

Pyrethroids and Their Effects on Ion Channels

Wakeling¹,

Neal²,

Atchison³

2012

Pesticides - Advances in Chemical and Botanical Pesticides

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Resistance to Pyrethrins and to Pyrethrins - Piperonyl Butoxide in a Wild Strain of Musca domestica L. in Sweden

Cited by 26 publications

References 1 publication

Emerging mosquito resistance to piperonyl butoxide-synergized pyrethroid insecticide and its mechanism

Emerging mosquito resistance to piperonyl butoxide-synergized pyrethroid insecticide and its mechanism

A Comprehensive Review on Neurotoxicity of Pyrethroids

Pyrethroids and Their Effects on Ion Channels

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