Resistance to Schistosoma bovis in Sheep Induced by an Experimental Fasciola hepatica Infection

Abstract

Sheep infected with Fasciola hepatica for 10 wk acquired a substantial level of resistance to challenge with Schistosoma bovis. The worm burden was reduced by 87.2% (P < 0.01) compared with that of a control group. But when sheep primarily were infected with S. bovis and 6 wk later with F. hepatica, no significant reduction in the S. bovis burden was observed.

Histopathological and Immunohistochemical Study of Lambs Experimentally Infected with Fasciola hepatica and Schistosoma bovis

“…A variety of biological activities such as secretion of cytokines and lysis of target cells have been ascribed to CC15 gd T cells (Abbas et al, 1994), whose expression has been also described in caprine S. bovis schistosomiasis (Lindberg et al, 1999). Likewise, our histopathological findings agree with parasitological findings (Rodríguez-Osorio et al, 1993) which indicated that F. hepatica did not have an influence on an established S. bovis infection. However schistosome-infected sheep resistant to challenge with F. hepatica when there was no deposition of schistosome eggs in the liver tissue at the time of challenge, have been described .…”

“…Also, protection against S. bovis infection induced by a primary infection with Fasciola gigantica (Yagi et al, 1986) or a previous immunization with a fatty acid-binding protein from F. hepatica (Fh12) (Aban et al, 1999), has been described in calves and mice, respectively. Similarly, Rodríguez-Osorio et al (1993) showed that sheep infected with F. hepatica acquired resistance to challenge with S. bovis with a significant reduction in the S. bovis burden. As cited above, in the literature reviewed the relationship between Schistosoma spp.…”

“…Faecal egg counts and macroscopic, histopathologic and immunohistochemical changes in liver and small intestine were used for assessment of possible cross-resistance. Moreover, parasitic-burden data from the same animals as previously published by Rodríguez-Osorio et al (1993) and results obtained by us were also taken into account.…”

Concurrent infections ofFasciola,SchistosomaandAmphistomumspp. in cattle from Kafue and Zambezi river basins of Zambia

“…An enhanced resistance against F. hepatica and F. gigantica after primary infection with S. bovis has been described in cattle (Sirag et al, 1981;Yagi et al, 1986) and sheep . These findings imply that these two trematodes may be susceptible to the same or similar immune responses (Spithill et al, 1999) and may have common antigens (Rodriguez-Osorio et al, 1993). These findings imply that these two trematodes may be susceptible to the same or similar immune responses (Spithill et al, 1999) and may have common antigens (Rodriguez-Osorio et al, 1993).…”

The combination of the aliphatic diamine AA0029 in ADAD vaccination system with a recombinant fatty acid binding protein could be a good alternative for the animal schistosomiasis control

“…A vaccine appears as a very valuable additional complement to mass chemotherapy in long-term disease control strategy. Vaccination is based on the partial resistance developed against the natural infection, the protection induced by irradiated cercariae and the cross-resistance stimulated by other flukes as Fasciola hepatica (Hewitson et al, 2005;Rodríguez-Osorio et al, 1993;Vercruysse and Gabriel, 2005).…”