Resistance Training and Protein Supplementation Increase Strength After Bariatric Surgery: A Randomized Controlled Trial

Oppert, Jean‐Michel; Bellicha, Alice; Roda, Célina; Bouillot, Jean‐Luc; Torcivia, Adriana; Clément, Karine; Poitou, Christine; Ciangura, C.

doi:10.1002/oby.22317

Cited by 84 publications

(188 citation statements)

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“…Interestingly, in a retrospective study of 100 patients after RYGB or sleeve gastrectomy, Smelt and colleagues found that post-operative handgrip strength, reflecting muscle strength, was impacted significantly by protein intake [51]. Oppert and colleagues went further with an 18-week, randomized, controlled trial assigning 26 obese women operated by RYGB to a control group, a group supplemented with whey protein, two powder drinks per day at a dose of 48 g/day, and a group combining resistance training 3 times per week with whey supplementation [52]. While they did not uncover a significant difference in lean mass loss between groups, for patients completing the whole study the muscle strength in lower and upper limbs relative to body weight and the protein intakes improved significantly in the group combining exercise and protein supplementation.…”

Section: Bariatric Surgery and Protein Changesmentioning

confidence: 99%

Protein, amino acids and obesity treatment

Simonson

Boirie‌

Guillet

2020

Rev Endocr Metab Disord

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Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial when it concerns fat mass, but loss of fat free massespecially muscle might be detrimental. This occurs because protein breakdown predominates over synthesis, thus administering anabolic dietary compounds like proteins might counter fat free mass loss while allowing for fat mass loss. Indeed, varying the quantity of proteins will decrease muscle anabolic response and increase hyperphagia in rodents fed a low protein diet; but it will favor lean mass maintenance and promote satiety, in certain age groups of humans fed a high protein diet. Beyond protein quantity, protein source is an important metabolic regulator: whey protein and plant based diets exercize favorable effects on the risk of developing obesity, body composition, metabolic parameters or fat free mass preservation of obese patients. Specific amino-acids like branched chain amino acids (BCAA), methionine, tryptophan and its metabolites, and glutamate can also positively influence parameters and complications of obesity especially in rodent models, with less studies translating this in humans. Tuning the quality and quantity of proteins or even specific amino-acids can thus be seen as a potential therapeutic intervention on the body composition, metabolic syndrome parameters and appetite regulation of obese patients. Since these effects vary across age groups and much of the data comes from murine models, long-term prospective studies modulating proteins and amino acids in the human diet are needed.

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Section: Bariatric Surgery and Protein Changesmentioning

confidence: 99%

Protein, amino acids and obesity treatment

Simonson

Boirie‌

Guillet

2020

Rev Endocr Metab Disord

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“…However, at the end of the study period, both groups displayed similar food pattern. Likewise, another recent RCT comparing protein supplementation with or without resistance training to usual follow-up in an unselected bariatric cohort did not evidence any difference in weight or body composition outcomes [67]. Overall, these data could suggest that synergic interventions post-BS should be proposed in selected individuals predicted to display a poor response (either poor weight-loss [61] or non-diabetes remission or diabetes relapse [64]) or at risk to display adverse surgery outcomes (bone fractures) to evaluate whether it improves further health outcomes.…”

Section: Functional Food Health Outcomes and Bariatric Surgery: Persmentioning

confidence: 93%

A place for vitamin supplementation and functional food in bariatric surgery?

Aron‐Wisnewsky

Clément

2019

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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 Purpose of review: This article summarizes the recent literature concerning vitamin deficiency and required supplementation post bariatric surgery (BS), with a focus on vitamin (and associated clinical adverse effect on bone loss) and on the potential implication of the gut microbiota.  Recent findings: BS improves health outcomes in terms of weight loss and metabolic alterations yet with major inter-individual variability. Indeed, although BS is efficient in most patients, some display poor response (i.e. patients with the lowest weight loss at one year or weight regain afterwards, or patients who do not undergo metabolic disease remission). Furthermore, despite systematic vitamin supplementation post-BS, some patients develop vitamin deficiencies leading to poor clinical outcomes. Specifically, a major recently described adverse outcome is vitamin D deficiency associated in part with observed bone mass loss and fractures. Recent mechanistic studies have been performed to better understand the involved physiopathology. Furthermore, different intervention studies tested on top of BS (using vitamin supplementation, diet or nutrients acting as functional food) have evaluated whether they could improve these nutritional adverse outcomes and are summarized herein. Importantly, gut microbiota involved in food digestion and metabolization as well as vitamin synthesis, is largely perturbed during severe obesity and is partially restored post-BS, yet again with large inter-individual variability. Whether differential modification of the gut microbiota could be associated with those vitamin deficiencies is an open question.  Summary: Future clinical research studies will need to evaluate whether add-on intervention to BS using vitamin, diet or specific food items could help prevent nutritional deficiencies and improve clinical response observed post-BS. More importantly, personalizing the add-on intervention after BS upon gut microbiota composition should be tested in predicted poor responders to BS as already performed during diet intervention to further improve metabolic health.

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“…Participants in the CON group were recruited among bariatric surgery patients with non‐syndromic obesity and had been included in a previous clinical trial (ClinicalTrials.gov website: NCT01113996). Data were collected from this group pre‐surgery, and details of this study, which was entirely performed at our university medical centre, can be found elsewhere (Oppert et al, ). Each participant of the PWS group was individually matched with two control participants for gender, age and per cent body fat.…”

Section: Methodsmentioning

confidence: 99%

“…PA and sedentary time were measured using a tri‐axial GT3x Actigraph accelerometer (Manufacturing Technology, Inc.), as previously described (Oppert et al, ). Participants were asked to wear the accelerometers at the hip using an elastic belt for seven consecutive days during all waking hours except during water‐based activities.…”

Section: Methodsmentioning

confidence: 99%

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Increasing physical activity in adult women with Prader–Willi syndrome: A transferability study

Bellicha

Coupaye

Hocquaux³

et al. 2019

Research Intellect Disabil

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Background The present authors aimed (a) to objectively quantify spontaneous physical activity (PA) in adult patients with Prader–Willi syndrome (PWS) and (b) to evaluate the transferability of a home‐based exercise training programme in these patients. Method Physical activity was compared between 10 adult women with PWS (PWS group) and 20 adult women with non‐syndromic obesity (CON group, for cross‐sectional comparison). In the PWS group, PA, body composition, walking capacity, quality of life and eating behaviour were then compared before and after a 16‐week supervised exercise programme. Results The PWS group displayed lower PA and higher sedentary time compared to the CON group. Median attendance to exercise sessions reached 100% (Q1‐Q3: 97%–100%) sessions. Moderate‐to‐vigorous PA and walking capacity increased after the programme without significant effect on body composition. Conclusion Supervised home‐based exercise sessions are an effective strategy to improve PA in women with PWS who are less active than women matched for adiposity.

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Resistance Training and Protein Supplementation Increase Strength After Bariatric Surgery: A Randomized Controlled Trial

Cited by 84 publications

References 46 publications

Protein, amino acids and obesity treatment

Protein, amino acids and obesity treatment

A place for vitamin supplementation and functional food in bariatric surgery?

Increasing physical activity in adult women with Prader–Willi syndrome: A transferability study

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