Resistance training improves muscle size and muscle strength in liver cirrhosis – a randomized controlled trial

Aamann, Luise; Dam, Gitte; Borre, Mette; Drljevic-Nielsen, Aska; Overgaard, Kristian; Andersen, H.; Vilstrup, Hendrik; Aagaard, Niels Kristian

doi:10.1016/s0168-8278(18)30377-5

Cited by 6 publications

(5 citation statements)

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“…Many studies have determined the effect of reducing WC by exercise and suggested that exercise might be potentially beneficial in reducing central obesity. [16][17][18] Likewise, in this study, body circumferences seem to be improved after exercise in both groups.…”

Section: Discussionsupporting

confidence: 76%

“…There is some debate about changes of body composition and blood profile after exercise. 4,[18][19][20][21][22][23][24] Various observations have suggested that specific exercise programs can affect muscle mass and fat mass. 4,22,23 However, other observations negated the possibility of im- provement in body composition or detected a spot improvement according to the type of exercise.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Physiological Effect of Exercise Training with Whole Body Electric Muscle Stimulation Suit on Strength and Balance in Young Women: A Randomized Controlled Trial

Park

Choi

et al. 2021

Chonnam Med J

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Many studies about Electrical muscle stimulation (EMS) have been performed to determine the effectiveness of EMS. However, most studies enrolled only elderly patients. Moreover, only a few studies have verified the effect of a whole body (WB)-EMS suit on young healthy women. Thus, the main purpose of this study was to verify the physiological effects of exercise training with a WB-EMS suit in young women. During the study periods, 24 young women were randomly assigned into two groups: 1) the WB-EMS training group, and 2) the control. All participants in the two groups performed the same low-intensity resistance exercise three times a week for 6 weeks at a training center. Group 1 used an electric current for WB-EMS suit which was switched on during the exercise period. Outcome measures were body composition, body circumference of hips and abdomen, isokinetic muscle function of knees, balance functions, Magnetic resonance imaging (MRI)s, cardiopulmonary functions, and lipid profiles. All outcomes were measured before and after the exercise protocol over 6 weeks. A total of 23 young women (group 1, n=11; group 2, n=12) completed a 6-week exercise regimen. After exercise, we compared the differences before and after the exercise program in each group. There were significant differences (p≤0.05) in body circumference, cardiopulmonary function in group 1 and 2. In particular, group 1 that activated WB-EMS showed significant differences in the isokinetic muscle function on knee flexors and balance functions. The results of this study show that exercise with a WB-EMS suit can be considered as an effective exercise addition for young women.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Physiological Effect of Exercise Training with Whole Body Electric Muscle Stimulation Suit on Strength and Balance in Young Women: A Randomized Controlled Trial

Park

Choi

et al. 2021

Chonnam Med J

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“…In patients undergoing TIPS, a significant increase in muscle mass on CT scan was found and associated with better survival [112]. Another work showed that cross sectional muscle area of quadriceps measured on MRI significantly increased in a group of patients following resistance training compared to controls [113].…”

Section: How To Follow Nutritional Status In Patients With Cirrhosis?mentioning

confidence: 99%

Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We Use in Clinical Practice?

et al. 2020

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Malnutrition is a common comorbidity in patients with cirrhosis. Its prognostic value is indisputable as it greatly affects the evolution of liver diseases. It has a major impact on both morbi-mortality before and after liver transplantation. Being now integrated in the definition of malnutrition and recognized as a new entity in the international classification of diseases, physicians have taken great interest in sarcopenia. Its negative consequences on the fate of patients with cirrhosis are well-demonstrated. The concept of frailty has recently been enlarged to chronic liver diseases as symptoms of impaired global physical functioning. In this article, we will discuss the definitions of malnutrition and emphasize its links with sarcopenia and frailty. We will show the relevance of frailty and sarcopenia in the course of liver diseases. The emerging role of muscle depletion on the cardiorespiratory system will also be highlighted. The importance of body composition will be demonstrated and the main tools reviewed. Finally, we adapted the definition of malnutrition to patients with cirrhosis based on the assessment of sarcopenia together with reduced food intakes.

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“…Most of the studies included in this review, focused on aerobic exercise intervention. A recently published abstract of randomized control trial by Aamann et al[59], not included in this review, evaluated the effect of resistance training with adequate protein intake showed significant increase in muscle mass, strength and quality of life scores. Similar to nutrition interventions, differences in the type of exercises, in the duration of the sessions, in the number of patients per session, supervised vs home based exercise found to effect outcomes in cirrhotic patients.…”

Section: Discussionmentioning

confidence: 99%

Interventions to improve sarcopenia in cirrhosis: A systematic review

Naseer

Turse

Syed

et al. 2019

WJCC

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BACKGROUNDSarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it is imperative to study interventions which targets to improve sarcopenia in cirrhosis.AIMTo examine the relationship between interventions such nutritional supplementation, exercise, combined life style intervention, testosterone replacement and trans jugular intrahepatic portosystemic shunt (TIPS) to improve muscle mass in cirrhosis.METHODSWe search PubMed, EMBASE and Cochrane between June-August 2018, without a limiting period and the types of articles (RCTs, clinical trial, comparative study) in adult patients with sarcopenia and cirrhosis. The primary outcome of interest was improvement in muscle mass, strength and physical function interventions mentioned above. In the screening process, 154 full text articles were included in the review and 129 studies were excluded.RESULTSWe identified 24 studies that met review inclusion criteria. The studies were diverse in terms of the design, setting, interventions, and outcome measurements. We performed only qualitative synthesis of evidence due to heterogeneity amongst studies. Risk of bias was medium in most of the included studies and low quality of evidence showed improvement in the muscle mass, strength and physical function following aerobic exercise. 60% of the included studies on the nutritional intervention, 100% of the studies on testosterone replacement in hypogonadal men and trans-jugular portosystemic shunt were proved to be effective in improving sarcopenia in cirrhosis.CONCLUSIONAlthough the quality of evidence is low, the findings of our systematic review suggest improvement in the sarcopenia in cirrhosis with exercise, nutritional interventions, hormonal and TIPS interventions. High quality randomized controlled trials needed to further strengthen these findings.

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Resistance training improves muscle size and muscle strength in liver cirrhosis – a randomized controlled trial

Cited by 6 publications

References 0 publications

Physiological Effect of Exercise Training with Whole Body Electric Muscle Stimulation Suit on Strength and Balance in Young Women: A Randomized Controlled Trial

Physiological Effect of Exercise Training with Whole Body Electric Muscle Stimulation Suit on Strength and Balance in Young Women: A Randomized Controlled Trial

Assessment of Malnutrition, Sarcopenia and Frailty in Patients with Cirrhosis: Which Tools Should We Use in Clinical Practice?

Interventions to improve sarcopenia in cirrhosis: A systematic review

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