Resistance training improves nerve conduction and arterial stiffness in older adults with diabetic distal symmetrical polyneuropathy: A randomized controlled trial

Gholami, Farhad; Khaki, Raziyeh; Mirzaei, Batool; Howatson, Glyn

doi:10.1016/j.exger.2021.111481

Cited by 12 publications

(2 citation statements)

References 47 publications

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“…Conversely, Li et al exhibited that the cardioankle vascular index decreased in young people for at least 60 min after acute resistance training (70% 1RM of lower limb vs. whole-body; 6 exercise, 4 sets; Li et al, 2015a). Similarly, a recent study reported an improvement in the cardio-ankle vascular index following 12-week resistance training (50-60% 1RM, 11 exercise, 1-3 sets) (Gholami et al, 2021). These findings reflect the beneficial effects of resistance training on elastic properties of systemic arteries.…”

Section: Discussionmentioning

confidence: 97%

Effects of 6-Week Traditional and Functional Resistance Training on Arterial Stiffness and Muscular Strength in Healthy Young Men

Zuo

Zhang

et al. 2022

Front. Physiol.

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BackgroundThe present study investigated the effects of traditional resistance training (TRT) and functional resistance training (FRT) on arterial stiffness and muscular strength in healthy young men.MethodsThis randomized controlled trial included 29 untrained healthy young men aged 18–29 years who were randomly divided into two groups, namely, TRT group (n = 15) and FRT group (n = 14). All participants underwent numerous tests, such as those for body composition, cardio-ankle vascular index, blood pressure, heart rate, and maximal strength before and after the 6-week training program. The exercise training comprised whole-body strength training exercises 3 days a week for 6 weeks. The total training volume and number of sets (4–5 sets) were kept constantly similar in each group. The TRT group completed 4–5 sets of 8–12 repetitions [70% of 1 repetition maximum (1RM)], whereas the FRT group completed 4–5 sets of 15–22 repetitions (40% 1RM).ResultsThe TRT and FRT groups exhibited equally significantly increased maximal strength (within group: both p < 0.01). Furthermore, the independent t-test showed that the differences between the two groups in terms of changes in maximal strength were no significant (between group: both p > 0.05). Additionally, significant main effects of time (pre vs. post) were observed for the left and right cardio-ankle vascular indices (p < 0.05); however, no significant difference were observed between the groups. For body compositions outcome measures, no significant differences between groups were observed.ConclusionSix weeks of FRT and TRT exhibit no difference in terms of effects on arterial stiffness and muscular strength.

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Section: Discussionmentioning

confidence: 97%

Effects of 6-Week Traditional and Functional Resistance Training on Arterial Stiffness and Muscular Strength in Healthy Young Men

Zuo

Zhang

et al. 2022

Front. Physiol.

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“…Even in elderly pts. with DM and at risk of leg ulcers, 3 months of three weekly resistance exercise training bouts may improve signs of peripheral artery stiffness ( Gholami et al, 2021 ). SGLT2i were early shown to lower not only blood sugars but also advanced glycation end-product formation in vessels ( Shen et al, 2012 ) and indeed lower indices of arterial stiffness ( Chilton et al, 2015 ; Davies et al, 2017 ; Pfeifer et al, 2017 ).…”

Section: Conduit Artery Remodelingmentioning

confidence: 99%

The cardiovascular changes underlying a low cardiac output with exercise in patients with type 2 diabetes mellitus

Lav Madsen,

Sejersen,

Nyberg

et al. 2024

Front. Physiol.

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The significant morbidity and premature mortality of type 2 diabetes mellitus (T2DM) is largely associated with its cardiovascular consequences. Focus has long been on the arterial atheromatosis of DM giving rise to early stroke and myocardial infarctions, whereas less attention has been given to its non-ischemic cardiovascular consequences. Irrespective of ischemic changes, T2DM is associated with heart failure (HF) most commonly with preserved ejection fraction (HFpEF). Largely due to increasing population ages, hypertension, obesity and T2DM, HFpEF is becoming the most prevalent form of heart failure. Unfortunately, randomized controlled trials of HFpEF have largely been futile, and it now seems logical to address the important different phenotypes of HFpEF to understand their underlying pathophysiology. In the early phases, HFpEF is associated with a significantly impaired ability to increase cardiac output with exercise. The lowered cardiac output with exercise results from both cardiac and peripheral causes. T2DM is associated with left ventricular (LV) diastolic dysfunction based on LV hypertrophy with myocardial disperse fibrosis and significantly impaired ability for myocardial blood flow increments with exercise. T2DM is also associated with impaired ability for skeletal muscle vasodilation during exercise, and as is the case in the myocardium, such changes may be related to vascular rarefaction. The present review discusses the underlying phenotypical changes of the heart and peripheral vascular system and their importance for an adequate increase in cardiac output. Since many of the described cardiovascular changes with T2DM must be considered difficult to change if fully developed, it is suggested that patients with T2DM are early evaluated with respect to their cardiovascular compromise.

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2023 update on Italian guidelines for the treatment of type 2 diabetes

Mannucci

Candido²,

Monache³

et al. 2023

Acta Diabetol

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Resistance training improves nerve conduction and arterial stiffness in older adults with diabetic distal symmetrical polyneuropathy: A randomized controlled trial

Cited by 12 publications

References 47 publications

Effects of 6-Week Traditional and Functional Resistance Training on Arterial Stiffness and Muscular Strength in Healthy Young Men

Effects of 6-Week Traditional and Functional Resistance Training on Arterial Stiffness and Muscular Strength in Healthy Young Men

The cardiovascular changes underlying a low cardiac output with exercise in patients with type 2 diabetes mellitus

2023 update on Italian guidelines for the treatment of type 2 diabetes

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