Resistance training-induced decrease in central arterial compliance is associated with decreased subendocardial viability ratio in healthy young men

Abstract

High-intensity resistance training decreases central arterial compliance (CAC). Subendocardial viability ratio (SEVR) is a useful tool that reflects the balance between coronary perfusion and left ventricular afterload. Animal studies have demonstrated that decreased CAC is associated with SEVR deterioration. Therefore, resistance training-induced decrease in CAC may be associated with changes in SEVR. The objective of the present study was to investigate the association between SEVR and CAC using both cross-sectional and longitudinal (i.e., resistance training) study designs. To achieve this, we first conducted a cross-sectional study to investigate the association between SEVR and CAC in 89 young men. Thereafter, a longitudinal study was performed to examine the effects of resistance training on SEVR and CAC in young men. A total of 28 young men were divided into 2 groups: control (n = 13) and training (n = 15). In the training group, subjects underwent supervised resistance training for 4 weeks (5 sets of 10 repetitions at 75% of 1-repetition maximum, 3 times/week). CAC and SEVR were then measured in all subjects. In the cross-sectional study, SEVR was significantly positively correlated with CAC, whereas resistance training significantly decreased both SEVR and CAC. Moreover, training-induced changes in CAC were significantly correlated with changes in SEVR. Thus, these results suggest that resistance training-induced decrease in CAC is associated with decreased SEVR in young men.

Aortic diastolic pressure decay modulates relation between worsened aortic stiffness and myocardial oxygen supply/demand balance after resistance exercise

“…Low BI indicates decreased subendocardial perfusion (5). We and other researchers have reported that high-intensity resistance exercise and regular high-intensity resistance exercise reduce BI (14,29). Furthermore, we revealed that a decrease in central arterial compliance (i.e., increased central arterial stiffness) induced by regular high-intensity resistance exercise was correlated with BI in young men (29).…”

“…We and other researchers have reported that high-intensity resistance exercise and regular high-intensity resistance exercise reduce BI (14,29). Furthermore, we revealed that a decrease in central arterial compliance (i.e., increased central arterial stiffness) induced by regular high-intensity resistance exercise was correlated with BI in young men (29). Therefore, it is considered that the increased central arterial stiffness with high-intensity resistance exercise deteriorates subendocardial perfusion.…”

“…Since we perceived an effect size of 0.42 (r) with a power of 0.80 and an ␣ level of 0.05, a sample size of 42 subjects was found to be necessary. This finding was based on the data of our previous study that found that a decrease in arterial compliance (i.e., increase in arterial stiffness) induced by habitual high-intensity resistance exercise was associated with a decrease in BI (29). To provide better confidence, we ultimately decided to include 52 subjects.…”

Association between circulating fibroblast growth factor 21, aerobic fitness, and aortic blood pressure in middle-aged and older women

“…The pressure wave at the carotid artery was recorded with the applanation tonometry sensor (TU-100; Colin Medical Technology, Aichi, Japan). Using the general transfer function-based pulse wave analysis software (Sphyg-moCor version 8.0; AtCor Medical, Australia), various parameters of the aortic pressure wave were computed from the carotid pressure waveform calibrated with MAP and brachial DBP, as we previously reported 21,22) . Briefly, aortic SBP and DBP were obtained as the maximum and minimum of the aortic pressure waveform, respectively.…”

The Effects of High Intensity Interval Training on Arterial Health

“…Interestingly, since resistance training has been shown to have detrimental effects on central arterial compliance including PWV [141][142][143] , while evidence states the opposite 144 , it would be interesting to see an exercise intervention comparing the effects of HIIT versus resistance training on parameters of central arterial compliance and stiffness. We also did not employ a nutritional intervention or calorie restriction study, which has shown beneficial effects on the general population 145 .…”