Resistance training prevents the cardiovascular changes caused by high-fat diet

Speretta, Guilherme Fleury Fina; Silva, André A.; Vendramini, Regina Célia; Zanesco, Angelina; Delbin, Maria Andréia; Menani, José Vanderlei; Bassi, Mirian; Colombari, Eduardo; Colombari, Débora S. A.

doi:10.1016/j.lfs.2016.01.011

Cited by 45 publications

(50 citation statements)

References 54 publications

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“…Our findings seem controversial in comparison with some previous reports on the protective effects of exercise on dietary fat-induced CVD (16–18). Instead of using moderate aerobic physical training like we successfully applied in both rat and mouse models against a life-threatening condition (24–26, 41), other authors used either high-intensity interval or resistance exercises (16–18).…”

Section: Discussioncontrasting

confidence: 99%

“…Instead of using moderate aerobic physical training like we successfully applied in both rat and mouse models against a life-threatening condition (24–26, 41), other authors used either high-intensity interval or resistance exercises (16–18). We should note that Boim and colleagues reported protective effects of exercise against hypertension and CVD risk when physically trained rats were treated with an aqueous extract of Phalaris canariensis L (56).…”

Section: Discussionmentioning

confidence: 99%

“…While unhealthy diet, sedentary habits, cigarette smoking, and obesity all act to increase the risk of CVD, previous reports predicted that lifestyle changes may remedy damaged structures in ~80% of cases (1, 15–18). Wisløff and colleagues reported that obese adolescents showed a reduced risk of CVD when they were physically trained twice a week using high-intensity exercises over 3-month period (19).…”

Section: Introductionmentioning

confidence: 99%

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High-Fat and Fat-Enriched Diets Impair the Benefits of Moderate Physical Training in the Aorta and the Heart in Rats

et al. 2017

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AimMillions of people die each year due to cardiovascular disease (CVD). A Western lifestyle not only fuses a significant intake of fat with physical inactivity and obesity but also promotes CVD. Recent evidence suggests that dietary fat intake impairs the benefits of physical training. We investigated whether aerobic training could reverse the adverse effects of a high-fat diet (HFD) on the aorta. Then, we explored whether this type of exercise could reverse the damage to the heart that is imposed by fat-enriched diet (FED).MethodsRats were randomly assigned to two experiments, which lasted 8 weeks each. First, rats swam for 60 min and were fed either a regular diet [standard diet (STD)] or an HFD. After aortic samples had been collected, the rats underwent a histopathological analysis for different biomarkers. Another experiment subjected rats that were fed either an STD or an FED to swimming for 20 or 90 min.ResultsThe first experiment revealed that rats that were subjected to an HFD-endured increased oxidative damage in the aorta that exercises could not counteract. Together with increased cyclooxygenase 2 expression, an HFD in combination with physical training increased the number of macrophages. A reduction in collagen fibers with an increased number of positive α-actin cells and expression of matrix metalloproteinase-2 occurred concomitantly. Upon analyzing the second experiment, we found that physically training rats that were given an FED for 90 min/day decreased the cardiac adipose tissue density, although it did not protect the heart from fat-induced oxidative damage. Even though the physical training lowered cholesterol levels that were promoted by the FED, the levels were still higher than those in the animals that were given an STD. Feeding rats an FED impaired the swimming protocol’s effects on lowering triglyceride concentration. Additionally, exercise was unable to reverse the fat-induced deregulation in hepatic antioxidant and lipid peroxidation activities.ConclusionOur findings reveal that an increased intake of fat undermines the potential benefits of physical exercise on the heart and the aorta.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High-Fat and Fat-Enriched Diets Impair the Benefits of Moderate Physical Training in the Aorta and the Heart in Rats

et al. 2017

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“…Aerobic exercise and physical fitness Long-term protective effects on risk of cardiovascular disorders [155,156].…”

Section: Specific Behavioral Interventionsmentioning

confidence: 99%

Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis

Santos

Snyder

et al. 2017

Alz & Dem Diag Ass & Dis Mo

335

263

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As the population ages due to demographic trends and gains in life expectancy, the incidence and prevalence of dementia increases, and the need to understand the etiology and pathogenesis of dementia becomes ever more urgent. Alzheimer's disease (AD), the most common form of dementia, is a complex disease, the mechanisms of which are poorly understood. The more we learn about AD, the more questions are raised about our current conceptual models of disease. In the absence of a cure or the means by which to slow disease progress, it may be prudent to apply our current knowledge of the intersection between AD, cardiovascular disease, and cerebrovascular disease to foster efforts to delay or slow the onset of AD. This review discusses our current understanding of the epidemiology, genetics, and pathophysiology of AD, the intersection between AD and vascular causes of dementia, and proposes future directions for research and prevention.

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“…The highest load that the animal successfully carried through the ladder was considered the MVCC for that training session. Failure was determined when the animal could not move up the ladder after three consecutive stimuli to the tail 21 . Three days after MVCC test, the resistance exercise protocol was performed as described above in the Experimental design.…”

Section: Resistance Exercisementioning

confidence: 99%

Acute effects of Resistance exercise performed on ladder on energy metabolism, stress, and muscle damage in rats

Silvestre

Speretta

Fabrizzi

et al. 2017

Motriz: rev. educ. fis.

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-Aim: To evaluate the acute effects of a resistance exercise session performed on ladder on energy metabolism, stress, and muscle damage in rats. Methods: Male Wistar rats were randomly distributed in Exercise (E) (n=30) and Control (C) (n = 20) groups. The E group performed a resistance exercise session on a vertical ladder with weights on their tails. Blood samples were collected at rest and after each climb to analyze lactate levels and ten minutes after the last climb to analyze lactate dehydrogenase (LDH), creatine kinase (CK), and corticosterone levels. Results: Blood lactate levels remained stable during exercise. Serum corticosterone, blood glucose, LDH and CK levels increased and glycogen content decreased in the E group, when compared to the C group. Conclusion: These results suggest that resistance exercise performed on ladder is a model of high-intensity exercise. However, the stabilization of lactate during the session suggests that the aerobic metabolism is an important factor during the intervals between climbs.

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Resistance training prevents the cardiovascular changes caused by high-fat diet

Abstract: The data demonstrated that moderate intensity RT prevented obesity-induced cardiovascular disorders simultaneously with reduced inflammatory responses and modifications of RAS in the NTS.

Cited by 45 publications

References 54 publications

High-Fat and Fat-Enriched Diets Impair the Benefits of Moderate Physical Training in the Aorta and the Heart in Rats

High-Fat and Fat-Enriched Diets Impair the Benefits of Moderate Physical Training in the Aorta and the Heart in Rats

Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis

Acute effects of Resistance exercise performed on ladder on energy metabolism, stress, and muscle damage in rats

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