Résistances acquises et prescriptions d'antibiotiques en Afrique: quelles adéquations?

Dosso, Mireille; Bissagnené, E.; Coulibaly, M.; Paye, H. Kette; N'Douba, A.; Guessennd, NK; Diaha, H.; Bouzid, S.; Koffi, Ccy; Mbengue, Ababacar; Adou, Pierre; Fofana, K.; Kadio, A.

doi:10.1016/s0399-077x(00)89090-3

Cited by 12 publications

(10 citation statements)

References 13 publications

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“…The high resistance rates could be explained by the fact that fluoroquinolones are the most prescribed molecules after β-lactam in Africa and particularly in Côte d'Ivoire [16]. These results are agree with those obtained by some authors in Africa.…”

Section: Discussionsupporting

confidence: 90%

First Case of Qnr B6 and Qnr B7 Genes in Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases in Abidjan, Côte D'ivoire

Victoire

Anatole

Fernique³

et al. 2019

SAJRM

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Aims: The aim of this study was to characterize fluoroquinolone resistance genes in enterobacteriaceae that produce extended-spectrum β-lactamases, isolated in Abidjan. Place and Duration of Study: Pasteur Institute of Côte d'Ivoire and research unit on emerging tropical infectious diseases of Aix-Marseille University from January 2017 at July 2017. Methodology: The study included 90 enterobacteriaceae producing extended-spectrum β-lactamases isolated from biological products from various hospital services in Abidjan. These strains have been pre-identified and stored at the Center for Biological Resources (CeReB) of Pasteur Institute of Côte d'Ivoire. The identification of the strains was confirmed using the mass spectrometry MALDI-TOF (MS) and the antibiotic sensitivity test was performed using Müeller Hinton's agar diffusion method. The fluoroquinolone resistant genes were detected by conventional PCR and then, sequenced. Results: The strains studied were Escherichia coli (44), Klebsiella pneumoniae (31) and Enterobacter cloacae (15). High resistance rates to ceftriaxone (96.7%), cefotaxime (95.6%), aztreonam (95.6%) and cefoxitin (72.2%) were observed in all strains producing broad spectrum β-lactamases. The resistance rate to fluororquinolones represented by ciprofloxacin was 86.7%. The fluoroquinolone resistance genes detected were qnr A (3.3%) and qnr B (42.2%). Sequencing identified the qnr A1 (3.3%), qnr B1 (31.1%), qnr B6 (2.2%) and qnr B7 (1.1%) genes. Conclusion: This study made it possible to identify fluoroquinolone resistance genes in enterobacteriaceae producing β-lactamases which have an extended spectrum in Abidjan.

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Section: Discussionsupporting

confidence: 90%

First Case of Qnr B6 and Qnr B7 Genes in Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases in Abidjan, Côte D'ivoire

Victoire

Anatole

Fernique³

et al. 2019

SAJRM

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“…Antibiotics, one of the most widely used and prescribed pharmaceuticals, are applied for killing microbes [1][2][3]. Recently the wide occurrence of antibiotics in groundwater raised concerns about potential adverse on human health and aquatic ecosystem [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical oxidation of amoxicillin in its pharmaceutical formulation at boron doped diamond (BDD) electrode

Quand-Même

Auguste

Hélène

et al. 2015

J. Electrochem. Sci. Eng.

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“…Although these studies provide significant data on global changes in the resistance pattern, none of these studies was conducted in West Africa. The PALM (Pan African Link through Microbiology) Project, which has been initiated by Smith Kline Beecham, conducted multicentric surveillance of antibiotic resistance in nine African countries, namely Kenya (East Africa), Cameroon (Central Africa), Nigeria, Senegal and Cote d 'Ivoire (West Africa), Morocco, 1'Algérie, and Tunisia (North Africa), and Malta [9]. However, very little data has been generated through this network [10].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility of select respiratory tract pathogens in Dakar, Senegal

Ndiaye

Edwige

Gueye

et al. 2009

J Infect Dev Ctries

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Background : Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogenes, and Streptococcus pneumoniae are the most common causative agents of respiratory tract infections (RTIs). The increase in resistance to current antibacterial agents highlights the need to monitor the resistance pattern of these bacterial pathogens. Methodology: In this study, we assessed the antibacterial susceptibility of these pathogens causing respiratory tract infections in Dakar, Senegal, during 2007. A total of 290 bacterial isolates (75 H. influenzae, 10 M. catarrhalis, 105 S. pneumoniae, and 100 S. pyogenes) were collected. Results and Conclusions: All H. influenzae isolates were susceptible to amoxicillin/clavulanic acid, ofloxacin, clarithromycin, cephalosporins, and macrolides. Overall, 26.7% of H. influenzae isolates were completely resistant to ampicillin. Among the M. catarrhalis isolates, 30% were resistant to ampicillin. All the isolates of H. influenzae and M. catarrhalis that were resistant to ampicillin were beta-lactamase producing strains. Among the S. pneumoniae isolates, 33.3% isolates exhibited intermediate susceptibility to penicillin G, and one isolate was completely resistant. All five isolates that were resistant to erythromycin expressed the M phenotype. S. pyogenes exhibited high susceptibility to all other antibiotics, except tetracycline. Our study suggests that except for M. catarrhalis, all other bacterial isolates are susceptible to cephalosporins, macrolides, and fluroquinolones.

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Résistances acquises et prescriptions d'antibiotiques en Afrique: quelles adéquations?

Cited by 12 publications

References 13 publications

First Case of Qnr B6 and Qnr B7 Genes in Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases in Abidjan, Côte D'ivoire

First Case of Qnr B6 and Qnr B7 Genes in Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases in Abidjan, Côte D'ivoire

Electrochemical oxidation of amoxicillin in its pharmaceutical formulation at boron doped diamond (BDD) electrode

Antimicrobial susceptibility of select respiratory tract pathogens in Dakar, Senegal

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