2022
DOI: 10.22270/jddt.v12i3-s.5372
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Resistant hypertension

Abstract: Background: Resistant hypertension is a common medical challenge facing clinicians and specialists. Although, the prevalence is currently unknown but various clinical trials have suggested that this problem is not rare. Resistant hypertension is blood pressure that remains above goal despite the use of at least three antihypertensive agents including a diuretic. It is a subtype of hypertension that increases the risk of cardiovascular, cerebrovascular and kidney disease. However, it is important to distinguish… Show more

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Cited by 4 publications
(4 citation statements)
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“…However, hypertension could be resistant (remain elevated) despite concurrent use of antihypertensive medications, resulting in suboptimal response (Acelajado et al, 2019;Moke et al, 2022). Most patients require more than one drug to achieve blood pressure control (Frohlich, 2011).…”
Section: Pharmacological Management Of Hypertensionmentioning
confidence: 99%
“…However, hypertension could be resistant (remain elevated) despite concurrent use of antihypertensive medications, resulting in suboptimal response (Acelajado et al, 2019;Moke et al, 2022). Most patients require more than one drug to achieve blood pressure control (Frohlich, 2011).…”
Section: Pharmacological Management Of Hypertensionmentioning
confidence: 99%
“…excessive salt and low potassium consumption, as well as a lack of physical exercise) (Mills, 2016). Another reason may be as a result of suboptimal outcome even with wellconstructed antihypertensive treatment regimens (resistant hypertension) (Acelajado et al, 2019;Carey 2020;Moke et al, 2022). However, variations in hypertension prevalence levels are not consistent over the world.…”
Section: Introductionmentioning
confidence: 99%
“…Antihypertensive medications are chemical substances used to prevent and treat excessive blood pressure (Jackson and Bellamy, 2015;Alawode et al, 2021). Angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), diuretics, calcium channel blockers (CCBs), and beta-blockers are the most widely prescribed antihypertensive medication groups (Khalil and Zeitser, 2020;Moke et al, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…Some allopathic agents applied in the management of hypertension include; adrenergic antagonists (alpha and beta receptor blockers) like prazosin and atenolol, centrally acting sympatholytic agents (alphamethyldopa, guanabenz and clonidine), calcium channel blockers (nifedipine and amlodipine), diuretics (hydrochlorothiazides), angiotensin converting enzyme inhibitors -ACEI (lisinopril and ramipril), angiotensin receptor antogonists -ARA (losartan and valsartan) and the aldosterone antagonists (spironolactone and eplerenone) have been extensively reported to elicit adverse effects like dry cough, severe hypotension, depressed libido and sometimes erectile dysfunction (Landazuri et al, 2017;Olowofela and Isah, 2017;Moke et al, 2022); as such, the antihypertensive effect achieved with these agents is always short lived. In addition to the arrays of these side effects, virtually all these antihypertensive agents are cost implicative, creating a huge burden in the purse of affected lowincome earners worldwide (Lacy et al, 2008;Pr et al, 2014).…”
Section: Introductionmentioning
confidence: 99%