Resistência aos medicamentos anti-tuberculose de cepas de Mycobacterium tuberculosis isoladas de pacientes atendidos em hospital geral de referência para tratamento de AIDS no Rio de Janeiro

Brito, Rossana Coimbra; Gounder, Celine R.; Lima, Dirce Bonfim de; Siqueira, HÃ©lio; Cavalcanti, Hebe Rodrigues; Pereira, Maracy Marques; Kritski, A. L.

doi:10.1590/s1806-37132004000400007

Cited by 20 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results of gender ( Fandinho et al 1999 , Brito et al 2004, Zaman et al 2005 , Mendes et al 2007 , Rozman et al 2007 , Vieira et al 2007 , Coelho et al 2012 , Micheletti et al 2014 ), mean age ( Teixeira et al 2001 , de Souza et al 2006, Mendes et al 2007, Rozman et al 2007, Vieira et al 2007, Marques et al 2010 , Coelho et al 2012, Micheletti et al 2014) and educational level (Brito et al 2004, Vieira et al 2007) were similar to other authors. These data demonstrate that TB mainly affects adult males with low educational levels ( Baptista et al 2002 , Melo et al 2003, Motta et al 2009 , Vendramini et al 2010, Valença et al 2012).…”

Section: Discussionsupporting

confidence: 69%

Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis

Pedro

Nardi

Pereira

et al. 2015

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

Drug-resistant tuberculosis (TB) is a growing global threat. Approximately 450,000 people developed multidrug-resistant TB worldwide in 2012 and an estimated 170,000 people died from the disease. This paper describes the sociodemographic, clinical-epidemiological and bacteriological aspects of TB and correlates these features with the distribution of anti-TB drug resistance. Mycobacterium tuberculosis (MT) cultures and drug susceptibility testing were performed according to the BACTEC MGIT 960 method. The results demonstrated that MT strains from individuals who received treatment for TB and people who were infected with human immunodeficiency virus were more resistant to TB drugs compared to other individuals (p < 0.05). Approximately half of the individuals received supervised treatment, but most drug-resistant cases were positive for pulmonary TB and exhibited positive acid-fast bacilli smears, which are complicating factors for TB control programs. Primary healthcare is the ideal level for early disease detection, but tertiary healthcare is the most common entry point for patients into the system. These factors require special attention from healthcare managers and professionals to effectively control and monitor the spread of TB drug-resistant cases.

show abstract

Section: Discussionsupporting

confidence: 69%

Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis

Pedro

Nardi

Pereira

et al. 2015

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…The prevalence of TB is higher among adult males than among adult females. (10,13,15,17,(25)(26)(27)31) However, it is not clear whether there is a real disparity in the prevalence of TB between genders or if confounding factors such as differences regarding access to treatment or stigmatization are involved. (30) Although injection drug users are more vulnerable to TB, (10)(11)(12)(15)(16) we found no correlation with this variable in the present study.…”

Section: Discussionmentioning

confidence: 99%

Prevalência e fatores associados à tuberculose em pacientes soropositivos para o vírus da imunodeficiência humana em centro de referência para tratamento da síndrome da imunodeficiência adquirida na região sul do Rio Grande do Sul

et al. 2006

View full text Add to dashboard Cite

Objective: In view of the relevance of co-infection with tuberculosis and human immunodeficiency virus, this study was designed to determine tuberculosis prevalence and identify factors related to tuberculosis in patients residing in a region in which both infections are highly prevalent. Methods: All patients treated during 1999 at the HIV/AIDS Clinic of the Universidade Federal do Rio Grande (Rio Grande Federal University) University Hospital were evaluated retrospectively, from the time of human immunodeficiency virus diagnosis, in terms of the incidence of tuberculosis and its relationship to sociodemographic, behavioral and immunological factors. Results: The sample included 204 patients, and tuberculosis prevalence was found to be 27%. The multivariate analysis showed a significant correlation between the development of tuberculosis and being of African descent (odds ratio: 4.76; 95% confidence interval: 1.93-11.72) and an inverse correlation between the development of tuberculosis and the TCD4+ lymphocyte count at the time of human immunodeficiency virus diagnosis (odds ratio: 0.995; 95% confidence interval: 0.993-0.997). When analyzed separately, other variables were found to be potential risk factors: being of the male gender (odds ratio: 2.49; 95% confidence interval: 1.15-5.39); and using illicit drugs (odds ratio: 2.1; 95% confidence interval: 1.02-4.31). Conclusion: The factors responsible for the development of tuberculosis among patients who are human immunodeficiency virus seropositive include immunological, socioeconomic and demographic factors. The high rate of tuberculosis prevalence among the seropositive patients underscores the urgent need to implement strategies that combine rapid identification and prompt treatment of individuals with active or latent infection, as well as of those with whom they have been in contact.

show abstract

“…Another study, also conducted in Rio de Janeiro, found no significant association between TB/HIV co-infection and resistance 15 . However, this is not the trend described in the international literature 16,17 , and according to the WHO, a large proportion of missing data on MDR-TB makes it impossible to conclude whether there is an overall association between MDR-TB and the HIV epidemic 18 .…”

Section: Discussionmentioning

confidence: 93%

Improving tuberculosis control through the partnership between university and the health system

Valença

Rocha

Ramis

et al. 2012

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

INTRODUCTION: Tuberculosis (TB) control is linked to the availability of qualified methods for microbiological diagnostics; however, microscopy with limited sensitivity is the only method available in many locations. The objective of this study was to evaluate the introduction of culture, drug susceptibility testing (DST), and genotyping in the routine of a Municipal Program of Tuberculosis Control. METHODS: Direct microscopy of sputum and culture in Ogawa-Kudoh were performed on 1,636 samples from 787 patients. DST of positive cultures was performed by resazurin microtiter assay and genotyping by mycobacterial interspersed repetitive units-variable number tandem repeat. RESULTS: A total 91 patients with TB were identified. The culture increased case detection by 32% compared with the microscopy; acquired resistance was 3.3% and the genotyping showed high genetic diversity. CONCLUSIONS: Ogawa-Kudoh contributed significantly to the increase in case detection and is suitable for implementation in poor-resource locations. The acquired resistance rate was lower than that reported in a recent Brazilian survey. The high genetic diversity is possibly related to the high TB prevalence in the population, as well as to early detection and suitable treatment of patients. The interaction between research and health care is important for reorienting the practice, transferring technology, and improving TB control.

show abstract

Resistência aos medicamentos anti-tuberculose de cepas de Mycobacterium tuberculosis isoladas de pacientes atendidos em hospital geral de referência para tratamento de AIDS no Rio de Janeiro

Cited by 20 publications

References 8 publications

Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis

Clinical and epidemiological profiles of individuals with drug-resistant tuberculosis

Prevalência e fatores associados à tuberculose em pacientes soropositivos para o vírus da imunodeficiência humana em centro de referência para tratamento da síndrome da imunodeficiência adquirida na região sul do Rio Grande do Sul

Improving tuberculosis control through the partnership between university and the health system

Contact Info

Product

Resources

About