Resistin and adiponectin in major depression: The association with free cortisol and effects of antidepressant treatment

Weber-Hamann, Bettina; Kratzsch, Jürgen; Kopf, Daniel; Lederbogen, Florian; Gilles, Maria; Heuser, Isabella; Deuschle, Michael

doi:10.1016/j.jpsychires.2006.01.002

Cited by 69 publications

(54 citation statements)

References 33 publications

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“…Furthermore, adipokines may be a mediating factor in the association between obesity and depression [6,7]. For example, leptin is associated with depressive vegetative symptoms, particularly changes in weight and appetite [8], and leptin itself has an antidepressant-like effect [9].…”

Section: Introductionmentioning

confidence: 99%

“…Reports of an association between low plasma levels of adiponectin and the risk for major depressive disorder (MDD) [10,11] suggest that anti-inflammatory adipokines are related to MDD. Furthermore, resistin levels in patients with MDD decline after remission by antidepressant treatment [7]. However, to date, most studies focusing on the association between adipokines and mood status have been conducted among patients with MDD.…”

Section: Introductionmentioning

confidence: 99%

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Leptin Is Associated with Mood Status and Metabolic Homeostasis in Patients with Bipolar Disorder

Lee

Kim

et al. 2014

Neuropsychobiology

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Background: Patients with bipolar disorder are at a high risk for becoming obese. Adipokines are associated with depression and obesity via the inflammatory process. However, few studies have investigated the associations between depression and leptin, adiponectin and resistin levels in patients with bipolar disorder. We explored the associations between serum levels of leptin, adiponectin and resistin and mood and metabolic status in patients with bipolar disorder. Methods: Body mass index (BMI) and serum leptin, adiponectin and resistin levels were assessed in 94 Korean patients with bipolar disorder. The Hamilton Rating Scale for Depression-17 and the Young Mania Rating Scale were used to assess mood state. Results: Leptin (17.19 ± 13.08 vs. 10.47 ± 10.05 ng/ml; p = 0.008) and adiponectin (10.51 ± 8.37 vs. 5.91 ± 2.82 μg/ml; p = 0.001) levels were higher in female than in male patients. After adjusting for mood state, age, smoking, alcohol habit, and BMI in a multivariate analysis of covariance (MANCOVA), leptin (17.86 ± 1.22 vs. 10.05 ± 1.48 ng/ml; p < 0.001) and adiponectin (10.18 ± 0.98 vs. 6.40 ± 1.19 μg/ml; p = 0.027) levels were still higher in female than in male patients. Compared to euthymic patients, depressed patients had higher levels of leptin (17.37 ± 14.69 vs. 11.65 ± 9.04 ng/ml; p = 0.024), but there was no significant difference in adiponectin and resistin levels between the two groups. After adjusting for age, gender and BMI in the MANCOVA, leptin levels were also significantly higher in depressed (16.78 ± 1.34 ng/ml) than in euthymic patients (10.73 ± 1.22 ng/ml; p = 0.001). Conclusion: Leptin is closely associated with the regulation of mood and metabolic homeostasis in patients with bipolar disorder. © 2014 S. Karger AG, Basel

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Leptin Is Associated with Mood Status and Metabolic Homeostasis in Patients with Bipolar Disorder

Lee

Kim

et al. 2014

Neuropsychobiology

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“…Regarding resistin, a positive association between blood levels and free cortisol concentrations were found in depressed patients. Resistin levels were normalized when patients remitted after pharmacological treatment but not in non-remitters 80 .…”

Section: Depression and Metabolic Syndromementioning

confidence: 93%

“…The variability could be due to antidepressant treatment which seems to increase adiponectin levels 79 . Yet, studies reporting no difference before and after treatment have also been published 80 . Regarding resistin, a positive association between blood levels and free cortisol concentrations were found in depressed patients.…”

Section: Depression and Metabolic Syndromementioning

confidence: 99%

The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review

Kučerová

Babinská

Horská

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. There is a growing interest in metabolic alterations in patients with psychiatric disorders due to their increased risk for metabolic syndrome (MetS) development. Inflammation is known to underlie the pathophysiology of schizophrenia and depression as well as MetS. Vulnerability factors for schizophrenia/depression and MetS hence appear to be shared. Methods and Results. Based on a Web of Science search, this review examines current evidence for MetS pathophysiology involving dysregulation of adipose tissue signaling -adipokines and pro-inflammatory cytokine, both also known to be aberrant in schizophrenia/depression. Further, gender differences in the incidence and course of schizophrenia/ depression were reported. The disturbances linked to the MetS are also described. Therefore, this review further maps the gender differences in the psychiatric-metabolic comorbidities. Conclusion. There is evidence supporting a pathological predisposition to MetS in both schizophrenia and depression in both humans and animal models. This predisposition is dramatically enhanced by antipsychotic medication. Further, there are gender differences from clinical findings suggesting women with schizophrenia/depression are more vulnerable to MetS development. This has not yet been assessed in animal studies. We suggest further validation of existing schizophrenia and depression animal models for the assessment of metabolic disturbances to provide tools for developing new antipsychotics and antidepressants with "metabolically inert" profile or improving the metabolic status in schizophrenic/depressed patients.

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“…Salivary biomarkers also include toxins, metabolites, enzymes (⍺ amylase, or ⍺-amylase), immunoglobulins (IgA), proteins and DNA. 35) Saliva contains the insulin sensitivity marker, adiponectin 36) cardiac enzymes such as creatinine kinase (CK), myoglobin (MB) 37) and creatine phosphokinase (CPK) 38) as well as neuroendocrine hormones such as epinephrine, norepinephrine, and DHEA 35. In the following section, we will review three major neuroendocrine markers (cortisol, ⍺-amylase, and DHEA) and inflammatory cytokines that are often measured in stress research.…”

Section: Utilization Of Salivary Endocrinal and Inflammatory Biomarkementioning

confidence: 99%

State of the Science: Salivary Biomarker Utilization for Stress Research

Starkweather

Sturgill

et al. 2014

Perspect Nurs Sci

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Associate Professor, University of Texas El Paso, Texas, USA Purpose: The use of salivary biomarkers for stress research is increasing based on the convenience of collection, affordability and scientific merit. This short review provides an overview of the state of the science of salivary biomarkers utilized in research related to stress. Methods: An integrative review was conducted. Results: The trend of utilizing salivary biomarkers in stress research was reviewed, specifically, focusing on the use of endocrine and inflammatory biomarkers incorporated in previous stress research. Then, a review of sampling procedures for salivary biomarkers and the analytic methods is provided. Finally, a discussion on the strengths and areas for improvement in the use of salivary biomarkers in stress research is included. Conclusion: Salivary biomarkers as an alternative to blood biomarkers are increasingly being recognized as a legitimate source for analyzing the stress response in humans.

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Resistin and adiponectin in major depression: The association with free cortisol and effects of antidepressant treatment

Cited by 69 publications

References 33 publications

Leptin Is Associated with Mood Status and Metabolic Homeostasis in Patients with Bipolar Disorder

Leptin Is Associated with Mood Status and Metabolic Homeostasis in Patients with Bipolar Disorder

The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review

State of the Science: Salivary Biomarker Utilization for Stress Research

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