Resistin and Cardiac Arrest—A Prospective Study

Tat, Raluca M; Golea, Adela; Rahaian, Rodica; Vesa, Ştefan Cristian; Ionescu, Daniela

doi:10.3390/jcm9010057

Cited by 8 publications

(5 citation statements)

References 48 publications

(63 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A close correlation between high serum resistin levels, cardiac comorbidities, and post-CA shock has been demonstrated, where the impact of post-CA shock on the serum resistin concentration was greater than that of cardiac comorbidities [99].…”

Section: Adipokinesmentioning

confidence: 83%

PCSK9 and Other Metabolic Targets to Counteract Ischemia/Reperfusion Injury in Acute Myocardial Infarction and Visceral Vascular Surgery

Ortona

Barisione

Ferrari

et al. 2022

JCM

View full text Add to dashboard Cite

Ischemia/reperfusion (I/R) injury complicates both unpredictable events (myocardial infarction and stroke) as well as surgically-induced ones when transient clampage of major vessels is needed. Although the main cause of damage is attributed to mitochondrial dysfunction and oxidative stress, the use of antioxidant compounds for protection gave poor results when challenged in clinics. More recently, there is an assumption that, in humans, profound metabolic changes may prevail in driving I/R injury. In the present work, we narrowed the field of search to I/R injury in the heart/brain/kidney axis in acute myocardial infarction, major vascular surgery, and to the current practice of protection in both settings; then, to help the definition of novel strategies to be translated clinically, the most promising metabolic targets with their modulatory compounds—when available—and new preclinical strategies against I/R injury are described. The consideration arisen from the broad range of studies we have reviewed will help to define novel therapeutic approaches to ensure mitochondrial protection, when I/R events are predictable, and to cope with I/R injury, when it occurs unexpectedly.

show abstract

Section: Adipokinesmentioning

confidence: 83%

PCSK9 and Other Metabolic Targets to Counteract Ischemia/Reperfusion Injury in Acute Myocardial Infarction and Visceral Vascular Surgery

Ortona

Barisione

Ferrari

et al. 2022

JCM

View full text Add to dashboard Cite

show abstract

“…Resistin is a marker of neutrophil activation 63 . Two studies, one released as two papers, reported an unadjusted association of resistin with 30‐day mortality 11,64,65 . When measured within 24 h of ROSC, resistin was more strongly associated with 30‐day mortality than NSE 65 .…”

Section: Resultsmentioning

confidence: 99%

“…63 Two studies, one released as two papers, reported an unadjusted association of resistin with 30-day mortality. 11,64,65 When measured within 24 h of ROSC, resistin was more strongly associated with 30-day mortality than NSE. 65 One study reported no association with six-month neurological outcome.…”

Section: Other Inflammatory Markersmentioning

confidence: 99%

Inflammatory response after out‐of‐hospital cardiac arrest—Impact on outcome and organ failure development

Seppa

Skrifvars

Pekkarinen

2023

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

BackgroundPost‐cardiac arrest syndrome that occurs in out‐of‐hospital cardiac arrest (OHCA) patients is characterized by inflammatory response. We conducted a scoping review of current evidence regarding several inflammatory markers' usefulness for assessment of patient outcome and illness severity. We also discuss the proposed underlying mechanisms leading to inflammatory response after OHCA.MethodsWe searched the MEDLINE, PubMed Central, Cochrane CENTRAL and Web of Science Core Collection databases with the following search terms: (“inflammation” OR “cytokines”) AND “out‐of‐hospital cardiac arrest.” Each inflammatory marker found was combined with “out‐of‐hospital cardiac arrest” using “AND” to find further relevant studies. We included original studies measuring inflammatory markers in adult OHCA patients that assessed their prognostic capabilities for mortality, neurological outcome, or organ failure severity.ResultsFifty‐nine studies met the inclusion criteria, covering in total 65 different markers. Interleukin‐6 (IL‐6), procalcitonin (PCT) and C‐reactive protein (CRP) were the most studied markers, and they were associated with poor outcomes in 13/15, 13/14 and 11/17 studies, respectively. Based on area under the receiver operating characteristic curve (AUC) value, the time point of best discriminatory capacity for poor outcome was ICU admission for IL‐6 (median AUC 0.78, range 0.71–0.98) and day one after OHCA for PCT (median AUC 0.84, range 0.61–0.98). Seven studies reported AUCs for CRP (range 0.52–0.76) with no measurement time point being superior to others. The association of IL‐6 and PCT with outcome appeared stronger in studies with more severely ill patients. Studies reported conflicting results regarding each marker's association with organ failure severity.ConclusionInflammatory markers are potentially useful for early risk stratification after OHCA. PCT and IL‐6 have moderate prognostic value during the first 24 h of the ICU stay. Predictive accuracy appears to be associated with the study overall event rate.

show abstract

“…Nine articles reported results as part of international research [18][19][20][21][22][23][24][25][26]. Research topics included resuscitation [21,[26][27][28][29][30], cardiovascular and respiratory pathologies (syncope [31,32], acute heart failure [22], asthma [25], and dyspnoea [24,33], infectious diseases [19,20], with 1 regarding the paediatric population [19], pre-hospital [18,23], toxicology [34][35][36], trauma [37], and upper gastrointestinal bleeding [38,39].…”

Section: Background and Aimsmentioning

confidence: 99%

“…Our ED has implemented one research protocol [29,30] and has been part of another international research group [24,25].…”

Section: Background and Aimsmentioning

confidence: 99%

Feasibility of a pilot study on point-of-care biomarkers in spontaneous intracerebral hemorrhage in an emergency setting

Mureșan

Golea

Bolboacă

et al. 2021

Medicine and Pharmacy Reports

Self Cite

View full text Add to dashboard Cite

Background and aims. Stroke is a worldwide leading cause of death and disability and spontaneous intracerebral hemorrhage (sICH) has significant economic and social impact, regardless of recent efforts towards outcome-bettering acute interventions. The aim of the study was to assess the feasibility of a prospective observational research regarding point-of-care (POC) biomarkers in sICH, conducted in a level one emergency department (ED). Methods. Patients with acute (<8 hours) sICH were enrolled in this study. Patients presenting a Glasgow Coma Scale score <8, secondary causes of intracerebral hemorrhage, seizures, recent ischemic events, known thromboembolic disease, anticoagulant treatment, severe pre-stroke disability, terminal disease, scheduled neurosurgery/ hemostatic treatment were excluded. Feasibility was defined as ED inclusion and follow-up rates, time-to-inclusion, and frequency of missing data. Baseline demographic, imaging and POC biochemical status of the study group were documented, including inflammatory (complete blood count, C-reactive protein), metabolic (glucose, hepatic, and renal function) and cardiovascular markers (cardiac troponin I, D-dimer). Results. The inclusion rate was 2.16 patients/month with a final sample of 35 patients out of 239 potentially eligible patients. The median time from symptom onset to ED presentation was 128 minutes (IQR 96-239), with 21/35 patients having presented within the first 3 hours from ictus. Median times between symptoms’ onset to Computer Tomography (CT) scan and ED presentation to CT scan were 170 minutes (IQR 126-317) and 25 minutes (IQR 17-62), respectively. The median time from patient’s presentation to CBC result was 12 minutes (IQR 6.5-20), with 21/35 study participants having the results available within 15 minutes from ED arrival. The median cohort age was 72-years, with a 19/16 male/female ratio. Hypertension was the most frequent risk factor (77%), along with ischemic heart disease (31%) and diabetes (29%). One-third of the hypertensive patients did not undergo blood pressure lowering treatment. Median values of POC biomarkers on ED admission were within normal range. Conclusions. It was feasible to determine point-of-care biomarkers in spontaneous intracerebral hemorrhage on admission in ED, despite the urgency of the medical condition.

show abstract

Resistin and Cardiac Arrest—A Prospective Study

Cited by 8 publications

References 48 publications

PCSK9 and Other Metabolic Targets to Counteract Ischemia/Reperfusion Injury in Acute Myocardial Infarction and Visceral Vascular Surgery

PCSK9 and Other Metabolic Targets to Counteract Ischemia/Reperfusion Injury in Acute Myocardial Infarction and Visceral Vascular Surgery

Inflammatory response after out‐of‐hospital cardiac arrest—Impact on outcome and organ failure development

Feasibility of a pilot study on point-of-care biomarkers in spontaneous intracerebral hemorrhage in an emergency setting

Contact Info

Product

Resources

About