Resistin and visfatin concentrations are related to central obesity and inflammation in Brazilian children

Abstract

Background: The evidence that cardiovascular disease begins in childhood and adolescence, especially in the presence of excess weight, is associated with dysfunction on adipokine pro-inflammatory secretion. These affect glucose metabolism and lead to other complications related to insulin resistance and cardiovascular disease. This study assessed the association of anthropometric and metabolic parameters related to obesity, cardiovascular risk, and insulin resistance with concentrations of resistin and visfatin, in children. Methods: A cross-sectional study was developed with 178 children of 6-10 years old enrolled in public city schools. Anthropometric data, composition body, clinical, and biochemical were measured according to standard procedures. We used multiple regression models by stepwise method to evaluate the associations of resistin and visfatin with variables of interest. Results: In healthy weight children, resistin was associated with LDL cholesterol, visfatin, atherogenic index, and waist-to-height ratio, whereas in obese children resistin was associated with visfatin and interaction between conicity index and HOMA-AD. Furthermore, in healthy weight children, visfatin was associated to resistin and triceps skinfold thickness and negatively associated to HOMA-AD, while in obese ones visfatin was associated with waistto-height ratio, atherogenic index, resistin, and interaction between trunk adiposity index and adiponectin and was negatively associated with the HOMA-IR index. Conclusions: Our study shows an association between anthropometric and biochemical variables related to visceral fat and inflammation. These results suggest the resistin and visfatin as good pro-inflammatory markers. In addition, both adipokines are strongly related to central obesity, in children.

Effect of Visfatin Level and Other Biochemical Parameters in Iraqi Children and Adolescents with Obesity

“…Similarly, this present study revealed positive correlations between visfatin and FBS in addition to HOMA-IR in both obese children and obese adolescents' groups. In contrast to previous findings obtained in obese children, a study by Simões et al [23] has shown visfatin negatively associated with HOMA-IR but this current study showed positive correlation between these two variables. The association between circulating visfatin and the parameters of glucose homeostasis and insulin resistance remains controversial due to contradicting data [24] [25] potentially due to the differences in immunoassay specificity [26].…”

Randomized Clinical and Biochemical Study Comparing the Effect of L-arginine and Sildenafil in Beta Thalassemia Major Children With High Tricuspid Regurgitant Jet Velocity

“…The findings obtained with the current study showed higher mean serum visfatin level for the recruited thalassemic patients (average value of 7.1 ng/mL and a range of 1.9-13.4 ng/mL) than that reported in the literature for normal weight healthy children (average value of 2.19 ng/mL and a range of 1.4-3.26 ng/mL). 38 The current results come in line with previous studies postulated higher level of adipocytokines notably visfatin among patients with b-thalassemia. It also indicates the possible inflammatory role of visfatin in this condition, the possible association of this adipocytokine with endothelial and vascular dysfunction in patients with b-thalassemia, and its correlation with disease severity.…”

Circulating NAMPT/ PBEF /Visfatin and its cardiometabolic risk in young obese adults

“…Dobiasova et al, (19) pointed AIP to be the significant predictor of cardiovascular risk for both research and for practice. Simões et al,(20) also demonstrated the atherogenic index of plasma as the best marker of atherosclerosis in their studies.…”