Resistin polymorphisms are associated with cerebrovascular disease in Finnish Type 2 diabetic patients

Kunnari, Anne; Ukkola, Olavi; Kesäniemi, Y. Antero

doi:10.1111/j.1464-5491.2005.01480.x

Cited by 67 publications

(55 citation statements)

References 33 publications

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“…Possible relationships between resistin gene polymorphisms and T2DM have been investigated in various studies [20][21][22][23][24][25][26][27]. Specifically, the analysis of a Japanese population consisting of 99 T2DM patients and 99 controls did not find any associations between three intronic SNPs and T2DM [23].…”

Section: Discussionmentioning

confidence: 99%

Association of Resistin Gene 3'-Untranslated Region EX4-44G-->A Polymorphism with Obesity- and Insulin-Related Phenotypes in Turkish Type 2 Diabetes Patients

Duman

Çağatay²,

Hatemi³

et al. 2007

Rev Diabet Stud

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■ AbstractResistin, an adipocyte-secreted hormone, has been associated with obesity, insulin resistance and type 2 diabetes mellitus (T2DM) in some, but not all, rodent models. In humans, the exact function of resistin is unkown. Because 3'-untranslated region (3'-UTR) single nucleotide substitutions (SNPs) have been shown to affect gene expression, we examined the EX4-44G→A SNP in the 3'-UTR of exon 3 within the resistin gene. The objective of this study was to investigate, for the first time in a Turkish study group, whether the 3'-UTR EX4-44G→A variation in the resistin gene influences the development of T2DM, obesity and insulin-related phenotypes. We analyzed the genotype frequencies of the EX4-44G→A polymorphism of the resistin gene in 116 type 2 diabetic and 102 normal subjects. Serum lipids, obesity-related and insulin-related phenotypes were analyzed. No significant difference for genotypic frequencies were observed for the BseRI restriction site in type 2 diabetic patients as compared to controls. Waist-to-hip ratio, BMI, body fat and apoAI levels were found to be affected by resistin genotype. In the control group, BMI (p < 0.01), HIS (p < 0.05) and BF (p < 0.05) levels were found to be elevated, whereas HOMA β-cell index (p < 0.01) and apo AI (p < 0.05) levels were found to be decreased in GG genotype carriers. In the diabetic group, the GG genotype carriers were found to have higher BMI levels (p<0.001), waistto-hip ratio (p < 0.05), body fat (p < 0.01), HOMA (p < 0.001) and fasting insulin (p < 0.05), but lower HbA1c levels in comparison to GC + AA carriers. These data suggest that, in the Turkish study group, the EX4-44G→A polymorphism of the resistin gene is associated with insulin and obesity-related phenotypes.

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Section: Discussionmentioning

confidence: 99%

Association of Resistin Gene 3'-Untranslated Region EX4-44G-->A Polymorphism with Obesity- and Insulin-Related Phenotypes in Turkish Type 2 Diabetes Patients

Duman

Çağatay²,

Hatemi³

et al. 2007

Rev Diabet Stud

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“…Supporting this theory, adults with MetS tend to have higher resistin levels than their healthy counterparts. 29 However, the correlation between insulin resistance and plasma resistin in adult humans remains controversial, supported by some studies 25,[35][36][37] and not in others, 4,21,34,38,39 and this therefore weakens the relation between resistin and MetS.…”

Section: Introductionmentioning

confidence: 99%

Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents

Fisette

et al. 2009

Int J Obes

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Objective: Resistin has been linked with obesity and hypothesized as a potential marker of insulin resistance in addition to being linked with acute inflammation. However, these links are still highly controversial in humans. Our goal was to examine resistin levels in relation to obesity, insulin resistance and inflammation markers in a large population of Asian children and adolescents. Methods: Children and adolescents (n ¼ 3472) aged 6-18 years, boys (n ¼ 1765) and girls (n ¼ 1707), were assessed for body size parameters, pubertal development, blood lipids, glucose, insulin, resistin, C-reactive protein (CRP), adiponectin and complement C3 (C3) levels. Results: Resistin increased with central obesity in both genders but not with simple adiposity in boys. Several markers associated with central obesity correlated in a gender-specific fashion with plasma resistin. Waist circumference, fat-mass percentage, waistto-height ratio and body mass index (BMI) positively correlated with resistin in both genders. Blood lipids such as triglycerides, nonesterified fatty acids (NEFA) and low-density lipoprotein cholesterol, diastolic and systolic blood pressure correlated positively with resistin in boys. NEFA, high-density lipoprotein cholesterol (negatively) and inflammation markers, such as CRP and C3, positively correlated with resistin in girls. There was no correlation between resistin and adiponectin, and no association of adiponectin with resistin quintiles in either boys or girls. In both boys and girls, resistin tended to decrease with age, with girls having higher levels than boys. Few indices of insulin resistance were linked with plasma resistin in either gender. Conclusion: In this population, plasma resistin levels are a weak biochemical marker of metabolic dysfunction defined by central obesity, adiposity and inflammation and does not predict insulin resistance. Only a small proportion of resistin variation can be explained by factors related to metabolic syndrome, suggesting that resistin is not strongly implicated in a concentrationdependent fashion in any of the examined pathologies.

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“…For example, although many studies report a lack of association between resistin gene variants and type 2 diabetes [4][5][6]10,[20][21][22][23][24][25], only one of these analyzed a sample population larger than 1000 subjects [4]. When data from three of the negative result studies [20][21][22] were analyzed together with new samples in a meta-analysis of 3536 subjects, the combined results showed an association between the −420C>G variant (RETN5) and diabetes [26].…”

Section: Discussionmentioning

confidence: 99%

“…Some genetic association analyses suggest a link between resistin gene variants and insulin resistance [4][5][6][7], while others report no such association [8,9]. Studies have found an association between certain resistin gene variants and increases in blood pressure in subjects with Type 2 diabetes mellitus, but not in controls without diabetes [4], while another reported an association between a resistin variant and hypertension only in non-diabetic controls, but not in subjects with diabetes [10].…”

Section: Introductionmentioning

confidence: 99%

Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure

Kimbell

Koropatnick

Grove

et al. 2008

Diabetes Research and Clinical Practice

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Aims-Although the function of resistin in human biology is unclear, some evidence suggests resistin gene variants influence insulin resistance, and insulin resistance-related hypertension. We searched for associations between common resistin gene variants and factors related to insulin resistance in Asian individuals with high or low blood pressure.Methods-Non-diabetic Chinese or Japanese sibling pairs were included if one had extreme hypertension and the other was either hypertensive or hypotensive. Four common, non-coding single nucleotide polymorphisms (SNPs) were identified by sequencing the resistin gene in 24 hypertensive probands. Generalized estimating equations-based regressions were then performed to test for SNP associations using the entire study population (n=1556).Results-Of 72 tests, only one was significant at the 0.05 level; 3.5 significant tests were expected by chance alone. High variability in insulin and triglyceride levels created wide confidence intervals, thus the negative results are not conclusive for these phenotypes. However, the large sample size resulted in narrow confidence intervals for BMI, fasting and 120 minute post-load glucose, and high and low density lipoprotein cholesterol. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of interest statementThe authors declare that they have no conflict of interest NIH Public Access Conclusion-Factors associated with insulin resistance are not likely influenced by the resistin gene in non-diabetic Asian individuals with high and low blood pressure.

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Resistin polymorphisms are associated with cerebrovascular disease in Finnish Type 2 diabetic patients

Abstract: The results suggest that resistin may play a role in atherogenesis probably through increasing insulin resistance.

Cited by 67 publications

References 33 publications

Association of Resistin Gene 3'-Untranslated Region EX4-44G-->A Polymorphism with Obesity- and Insulin-Related Phenotypes in Turkish Type 2 Diabetes Patients

Association of Resistin Gene 3'-Untranslated Region EX4-44G-->A Polymorphism with Obesity- and Insulin-Related Phenotypes in Turkish Type 2 Diabetes Patients

Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents

Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure

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