Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas

Greenfield, Jeffrey P.; Cobb, William S.; Lyden, David

doi:10.1172/jci42345

Cited by 37 publications

(32 citation statements)

References 25 publications

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“…Our approach to examining the effects of AMD3100 in a complex in vitro microenvironmental model of neovascularization may prove significant for understanding the mechanisms of action of this and other drugs and associated molecules in promoting or inhibiting revascularization and for more clearly defining the experimental approach to testing or assessing the effects of such drugs in vitro and subsequently in vivo. Understanding such mechanisms as those exemplified here with CXCL12 in new blood vessel formation has translational implications that include inhibition of tumor progression and promotion of tissue repair and regeneration as diverse as peripheral arterial disease and ischemic injury, burn injury, neurodegenerative disease, and hematological regeneration [5][6][7]11,18,22,[56][57][58][59][60].…”

Section: Fig 6 Cd31 Blocks Integration Of Exogenous Huvecs Into Immmentioning

confidence: 99%

The Hematopoietic Chemokine CXCL12 Promotes Integration of Human Endothelial Colony Forming Cell–Derived Cells into Immature Vessel Networks

Newey

Tsaknakis

Khoo

et al. 2014

Stem Cells and Development

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Section: Fig 6 Cd31 Blocks Integration Of Exogenous Huvecs Into Immmentioning

confidence: 99%

The Hematopoietic Chemokine CXCL12 Promotes Integration of Human Endothelial Colony Forming Cell–Derived Cells into Immature Vessel Networks

Newey

Tsaknakis

Khoo

et al. 2014

Stem Cells and Development

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“…In tumors transplanted into mice and irradiated, recruitment through hypoxia of BM-derived cells occurs, able to restore circulation through SDF1 and CXCR4 [134]; among these cells, EPCs prevail [121,[135][136][137]. Vasculogenesis can be blocked by pharmacological inhibition or antibodies toward SDF1 and CXCR4 [134].…”

Section: Perivascular Niches (Pvn) Relationship Between Npcs/gscs Anmentioning

confidence: 99%

Tumor Microenvironment — Perivascular and Perinecrotic Niches

Schiffer¹,

Mellai²,

Annovazzi³

et al. 2015

Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients With a Brain Tumor

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“…The SDF-1α/CXCR4 signaling plays an important role in glioma vasculogenesis and angiogenesis, which is regarded as a cross talk between endothelial and tumor cells. Vasculogenesis and angiogenesis, although endothelial cells are involved in both of them, are supposed to play distinct roles in the etiology of primary and recurrent malignant gliomas [179,180]. Kenig et al [181] reported that co-culturing of human GBM cells with HBMECs enhances tumor invasion and endothelial proliferation through the secretion of SDF-1α and SDF-1α-induced activity of MMP-9.…”

Section: Roles Of the Sdf-1α/cxcr4 Axis In Gliomamentioning

confidence: 99%

Contribution of SDF-1a/CXCR4 Signaling to Brain Development and Glioma Progression

et al. 2013

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The SDF-1α/CXCR4 signaling maintains central nervous system homeostasis through the interaction with the neurotransmitter and neuropeptide systems, the neuroendocrine systems. Recently, the SDF-1α/CXCR4 signaling has been reported to present nonrandom distribution in brain development and glioma progression, which exerts differential regulations on the assembly, differentiation, and function of neural precursors, neurons, glial cells, as well as glioma cells. In the present review, we highlight current knowledge about multiple molecular signaling pathways associated with the SDF-1α/CXCR4 signaling in glioma. Not only is the expression of CXCR4 a key determinant of glioma progression, but SDF-1α is essential for site-specific invasive or metastatic processes. SDF-1α is the switch of the SDF-1α/CXCR4 signaling from the endocrine loop to the autocrine and/or local paracrine loop in glioma progression and brain development. Studies of SDF-1α/CXCR4 signaling in the field of brain development may provide valuable tactics for glioma treatment.

show abstract

Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas

Cited by 37 publications

References 25 publications

The Hematopoietic Chemokine CXCL12 Promotes Integration of Human Endothelial Colony Forming Cell–Derived Cells into Immature Vessel Networks

The Hematopoietic Chemokine CXCL12 Promotes Integration of Human Endothelial Colony Forming Cell–Derived Cells into Immature Vessel Networks

Tumor Microenvironment — Perivascular and Perinecrotic Niches

Contribution of SDF-1a/CXCR4 Signaling to Brain Development and Glioma Progression

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