Resistive coupled microwave sintering of hydroxyapatite/titania nano-biocomposite and tailoring its mechanical properties

Swapna, Yalamanchili; Mathew, C.T.; Thomas, J.K.

doi:10.1016/j.jmbbm.2023.105772

Cited by 3 publications

(3 citation statements)

References 45 publications

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“…Regarding shape, the reinforcing materials for CaPO 4 include particles [941,942], platelets [943,944], whiskers [580,664,[945][946][947], and fibers [948][949][950][951][952], regarding their sizes, they can be of nano-(Section 5.3 above), micro-, and macro-dimensions, and certainly they can be of diverse chemical composition. Namely, zirconia and PSZ [931][932][933][934]945,[953][954][955][956][957][958][959][960][961], magnesia [962], alumina [941,944,[963][964][965][966], alumina + magnesia [967], titania [968][969][970][971], alumina + titania [972], iron oxides [973][974][975][976] (Figure 9), other oxides and mixtures thereof ...…”

Section: Biocomposites With Glasses Inorganic Compounds Metals and Ca...mentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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The goal of this review is to present a wide range of hybrid formulations and composites containing calcium orthophosphates (abbreviated as CaPO4) that are suitable for use in biomedical applications and currently on the market. The bioactive, biocompatible, and osteoconductive properties of various CaPO4-based formulations make them valuable in the rapidly developing field of biomedical research, both in vitro and in vivo. Due to the brittleness of CaPO4, it is essential to combine the desired osteologic properties of ceramic CaPO4 with those of other compounds to create novel, multifunctional bone graft biomaterials. Consequently, this analysis offers a thorough overview of the hybrid formulations and CaPO4-based composites that are currently known. To do this, a comprehensive search of the literature on the subject was carried out in all significant databases to extract pertinent papers. There have been many formulations found with different material compositions, production methods, structural and bioactive features, and in vitro and in vivo properties. When these formulations contain additional biofunctional ingredients, such as drugs, proteins, enzymes, or antibacterial agents, they offer improved biomedical applications. Moreover, a lot of these formulations allow cell loading and promote the development of smart formulations based on CaPO4. This evaluation also discusses basic problems and scientific difficulties that call for more investigation and advancements. It also indicates perspectives for the future.

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Section: Biocomposites With Glasses Inorganic Compounds Metals and Ca...mentioning

confidence: 99%

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Dorozhkin

2024

J. Compos. Sci.

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“…14,21 TiO 2 also has a higher mechanical strength than HA and has been shown to improve mechanical strength without worsening biocompatibility when added to calcium phosphate ceramics. 22,23 Past investigations on these composites have also shown increases in fracture strength, toughness, and stiffness in comparison to only HA. 24,25 As stated, HA and TiO 2 are both biocompatible ceramics with suitable properties to be used as bone substitute.…”

Section: Introductionmentioning

confidence: 96%

“…This capability helps it perform a major role as the intermediate layer between titanium alloy implants and the calcium phosphate coatings 14,21 . TiO 2 also has a higher mechanical strength than HA and has been shown to improve mechanical strength without worsening biocompatibility when added to calcium phosphate ceramics 22,23 . Past investigations on these composites have also shown increases in fracture strength, toughness, and stiffness in comparison to only HA 24,25 .…”

Section: Introductionmentioning

confidence: 99%

Freeze casting of hydroxyapatite‐titania composites for bone substitutes

Yin,

Steyl,

Howard

et al. 2023

J Biomedical Materials Res

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Hydroxyapatite (HA) is commonly used as a bone substitute material, but it lacks mechanical strength when compared to native bone tissues. To improve the efficacy of HA as a bone substitute by improving the mechanical strength and cell growth attributes, porous composite scaffolds of HA and titania (HA‐TiO2) were fabricated through a freeze‐casting process. Three different compositions by weight percent, 25–75 HA‐TiO2, 50–50 HA‐TiO2, and 75–25 HA‐TiO2, were custom‐made for testing. After sintering at 1250°C, these composite scaffolds exhibited improved mechanical properties compared to porous HA scaffolds. Substrate mixing was observed, which helped reduce crystal size and introduced new phases such as β‐TCP and CaTiO3, which also led to improved mechanical properties. The composition of 50–50 HA‐TiO2 had the highest ultimate compressive strength of 3.12 ± 0.36 MPa and elastic modulus 63.29 ± 28.75 MPa. Human osteoblast cell proliferation assay also increased on all three different compositions when compared to porous HA at 14 days. These results highlight the potential of freeze casting composites for the fabrication of bone substitutes, which provide enhanced mechanical strength and biocompatibility while maintaining porosity.

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Preparation of 3D printed silicon nitride bioceramics by microwave sintering

Zeng,

Sipaut,

Ismail

et al. 2024

Sci Rep

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Silicon nitride (Si3N4) is a bioceramic material with potential applications. Customization and high reliability are the foundation for the widespread application of Si3N4 bioceramics. This study constructed a new microwave heating structure and successfully prepared 3D printed dense Si3N4 materials, overcoming the adverse effects of a large amount of 3D printed organic forming agents on degreasing and sintering processes, further improving the comprehensive performance of Si3N4 materials. Compared with control materials, the 3D printed Si3N4 materials by microwave sintering have the best mechanical performance: bending strength is 928 MPa, fracture toughness is 9.61 MPa·m1/2. Meanwhile, it has the best biocompatibility and antibacterial properties, and cells exhibit the best activity on the material surface. Research has shown that the excellent mechanical performance and biological activity of materials are mainly related to the high-quality degreasing, high cleanliness sintering environment, and high-quality liquid-phase sintering of materials in microwave environments.

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Resistive coupled microwave sintering of hydroxyapatite/titania nano-biocomposite and tailoring its mechanical properties

Cited by 3 publications

References 45 publications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Calcium Orthophosphate (CaPO4) Containing Composites for Biomedical Applications: Formulations, Properties, and Applications

Freeze casting of hydroxyapatite‐titania composites for bone substitutes

Preparation of 3D printed silicon nitride bioceramics by microwave sintering

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