2006
DOI: 10.1007/s00216-006-0346-0
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Resolution of an intense sweetener mixture by use of a flow injection sensor with on-line solid-phase extraction

Abstract: An integrated solid-phase spectrophotometry-FIA method is proposed for simultaneous determination of the mixture of saccharin (1,2-benzisothiazol-3(2H)-one-1,1-dioxide; E-954) (SA) and aspartame (N-L-alpha-aspartyl-L-phenylalanine-1-methyl ester; E-951) (AS). The procedure is based on on-line preconcentration of AS on a C18 silica gel minicolumn and separation from SA, followed by measurement, at lambda = 210 nm, of the absorbance of SA which is transiently retained on the adsorbent Sephadex G-25 placed in the… Show more

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Cited by 27 publications
(15 citation statements)
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“…Another classification of artificial sweeteners grouped them into synthetic, semisynthetic and natural. They comprise of a wide variety of organic molecules (example, carbohydrate derivatives, salts of organic acids, terpenoids and even proteins (Capitan-Vallvey et al, 2006).…”
Section: Sweetenersmentioning
confidence: 99%
“…Another classification of artificial sweeteners grouped them into synthetic, semisynthetic and natural. They comprise of a wide variety of organic molecules (example, carbohydrate derivatives, salts of organic acids, terpenoids and even proteins (Capitan-Vallvey et al, 2006).…”
Section: Sweetenersmentioning
confidence: 99%
“…This means they must be separated to resolve the mixture. We previously studied the resolution of the sweetener mixture of AS and SA including a mini-column filled with C 18 silica (300 mg, bead size 20-80 mm) in the flow setup, [4] but this has the disadvantages of high back pressure and low separative power. The aim of this study is to explore the possibilities offered by commercial ion-exchange monolithic disks for the separation of organic compounds using an FIA scheme.…”
Section: Variablesmentioning
confidence: 99%
“…FIA methods can include separative steps to improve their capabilities. [1] Commonly, the separative FIA systems based on solid phase supports can only separate binary mixtures by different ways: 1) the use of microcolumns to retain one analyte, although both analytes are transiently retained in the solid support that fills the flow cell after they pass or are eluted; [2][3][4] 2) the use of microcolumns to retain one analyte which is also retained in the solid support placed in the flow cell, while the other analyte is measured when it flows amid the interstitial solution through the particles; [5] 3) the use of the differences in the transient retention of both analytes in the flow cell. The transient retention of one analyte in the upper part of the flow cell, away from the measuring area, makes it possible to measure the one that is less retained and, thus its resolution; [6,7] 4) the use of a chemometric approach without separation of the analytes prior to the detection step.…”
Section: Intense Sweetener Mixture Resolution By Flow Injection Methomentioning
confidence: 99%
“…However, there are also examples of the use of capillary electrophoresis (Herrmannovà, Křivànkova, Bartoš, & Vytřas, 2005;Pesek & Matyska, 1997), flow injection (Capitán-Vallvey, Valencia, Nicolás, & García-Jiménez, 2006;Peña, Limba, & Saraiva, 2004), biosensors (Campanella, Aturki, Sammartino, & Tomassetti, 1995) and voltammetry (Medeiros, De Carvalho, Rocha-Filho, & Fatibello-Filho, 2008) applications for aspartame quantitative determination. Spectrophotometry (Cantarelli, Pellerano, Marchevsky, & Camiña, 2009) and infrared spectroscopy (Khurana, Cho, Shim, Li, & Jun, 2008;Kizil, Irudayaraj, & Seetharaman, 2002) in conjunction with multivariate techniques of data treatment were applied for aspartame quantification.…”
Section: Introductionmentioning
confidence: 98%