Resolution of aquagenic pruritus with intermittent <scp>UVA</scp>/<scp>NBUVB</scp> combined therapy

Morgado‐Carrasco, Daniel; Riera‐Monroig, Josep; Fustà‐Novell, Xavier; Podlipnik, Sebastián; Aguilera, Paula

doi:10.1111/phpp.12320

Cited by 10 publications

(12 citation statements)

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“…More recently, superiority of NB-UVB compared with PUVA has been shown for urticaria ( 101 ), and thus NB-UVB should be considered as a treatment option if antihistamines and other pharmacological therapies fail and may provide useful disease remission. A range of other conditions may be effectively treated by NB-UVB and PUVA and include pityriasis lichenoides ( 102 ), granuloma annulare ( 103 , 104 ), urticaria pigmentosa and cutaneous mastocytoses ( 105 – 107 ), aquagenic pruritus ( 108 – 110 ), lichen planus ( 111 – 114 ), alopecia areata ( 115 – 118 ), generalized pruritus, such as secondary to uraemia or cholestasis ( 119 , 120 ), and graft vs. host disease ( 2 , 3 , 5 , 6 ) and these phototherapeutic modalities may be invaluable treatment approaches for these otherwise difficult-to-treat groups of diseases. For conditions such as pityriasis rubra pilaris, which may be aggravated and flared by the use of NB-UVB, 8-MOP systemic PUVA should be considered.…”

Section: Other Indicationsmentioning

confidence: 99%

A Perspective on the Use of NB-UVB Phototherapy vs. PUVA Photochemotherapy

Ibbotson

2018

Front. Med.

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Narrowband UVB (NB-UVB) phototherapy and psoralen-UVA (PUVA) photochemotherapy are widely used phototherapeutic modalities for a range of skin diseases. The main indication for NB-UVB and PUVA therapies is psoriasis, and other key diagnoses include atopic eczema, vitiligo, cutaneous T-cell lymphoma (CTCL), and the photodermatoses. The decision on choice of phototherapy is important and NB-UVB is usually the primary choice. NB-UVB phototherapy is a safe and effective therapy which is usually considered when topical agents have failed. PUVA requires prior psoralen sensitization but remains a highly effective mainstay therapy, often used when NB-UVB fails, there is rapid relapse following NB-UVB or in specific indications, such as pustular or erythrodermic psoriasis. This review will provide a perspective on the main indications for use of NB-UVB and PUVA therapies and provide comparative information on these important dermatological treatments.

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Section: Other Indicationsmentioning

confidence: 99%

A Perspective on the Use of NB-UVB Phototherapy vs. PUVA Photochemotherapy

Ibbotson

2018

Front. Med.

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“…Moreover, UVB‐311 nm irradiation has immunomodulatory effects and results in tanning of the skin due to enhanced melanin synthesis, thus reducing the effect of light on dermal mast cells. The additional protective effect of UVB‐311 nm is also known from other photodermatoses triggered by UVA and has also been described in aquagenic pruritus [36--38, 40.…”

Section: Discussionmentioning

confidence: 99%

“…After achieving remission, the frequency was reduced to three times and, if possible, two times per week. The chosen doses corresponded to the recommendations of the currently valid guidelines for phototherapy with UVB light [39,40].…”

Section: Both Arms Ventrally Total Body Ventrallymentioning

confidence: 99%

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Solar urticaria: Clinic, diagnostic, course and therapy management in 27 patients

Gaebelein-Wissing

Ellenbogen

Lehmann

2020

J Deutsche Derma Gesell

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Background and objectives: Solar urticaria is a rare photodermatosis, the diagnosis and therapy of which have not yet been standardized. The aim of this research was to use innovative radiation sources for diagnostics with defined and reproducible emission spectra and doses. A uniform therapy step scheme was to be created. Patients and methods: In a longitudinal study, 27 patients with solar urticaria were examined over 13 years. With a characteristic anamnesis, the diagnosis was confirmed with phototesting (photoprovocation) from various radiation sources (UVB, UVB-311nm, UVA, UVA-1, green light, red light) and a therapy step scheme was designed consisting of light protection, antihistamines, rush hardening with UVA-1, and administration of omalizumab. Results: Action spectrum: UVB 44 %, UVA 70 %, UVA-1 89 %, green light 37 % and red light 22 %. Rush hardening with subsequent maintenance therapy was performed on 20 patients, 17 of whom were hereby adequately protected. In three further patients, omalizumab was additionally administered. Conclusions: Phototesting with UVB, UVB311nm, UVA, UVA-1, and visible light with innovative radiation sources is uniformly possible in every major skin clinic. With the help of the therapy step scheme the patients can be adjusted well. Rush hardening with UVA-1 is a safe method to help the patients during the sunny season. Omalizumab as the last therapy option is effective, but currently only possible in off-label use.

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“…Diese Bestrahlungen wurden zunächst täglich durchgeführt und bei erreichter Remission die wöchentliche Frequenz auf drei Mal und, wenn möglich, auf zwei Mal reduziert. Die gewählten Dosen entsprachen den Empfehlungen der aktuell gültigen Leitlinie für Phototherapie mit UVB‐Licht [39--40].…”

Section: Patientenkollektiv/materials Und Methodenunclassified