Resolution of bone, cutaneous, and muscular involvement after haploidentical hematopoietic stem cell transplantation followed by post‐transplant cyclophosphamide in adult T‐cell leukemia/lymphoma

Iioka, Futoshi; Tanabe, Hiroshi; Honjo, Gen; Murakami, Takashi; Ohno, Hitoshi

doi:10.1002/ccr3.2925

Cited by 1 publication

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, an effective and safe approach is required, in the future, to improve survival following remission of AML ( 117 ). In addition, a female patient with adult T-cell leukemia/lymphoma involving bone, skin, and skeletal muscle exhibited a favorable post-transplant course after receiving cyclophosphamide following allo-HSCT from her son in a clinical case report ( 124 ). There has been no progression of disease for more than two years, suggesting that this approach offers a well-tolerated and potentially curable treatment for this hard-to-treat disease ( 124 ).…”

Section: Clinical Applicationmentioning

confidence: 99%

“…In addition, a female patient with adult T-cell leukemia/lymphoma involving bone, skin, and skeletal muscle exhibited a favorable post-transplant course after receiving cyclophosphamide following allo-HSCT from her son in a clinical case report ( 124 ). There has been no progression of disease for more than two years, suggesting that this approach offers a well-tolerated and potentially curable treatment for this hard-to-treat disease ( 124 ). Given the high toxicity of this treatment, graft-anti-leukemia response and the high recurrence and mortality rate, novel post-transplantation maintenance regimens need to be studied.…”

Section: Clinical Applicationmentioning

confidence: 99%

See 1 more Smart Citation

Fate of hematopoietic stem cells determined by Notch1 signaling (Review)

Wang

Zhang

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

Regulation of the fate of hematopoietic stem cells (HSCs), including silencing, self-renewal or differentiation into blood line cells, is crucial to maintain the homeostasis of the human blood system and prevent leukemia. Notch1, a key receptor in the Notch signaling pathway, plays an important regulatory role in these properties of HSCs, particularly in the maintenance of the stemness of HSCs. In recent decades, the ubiquitination modification of Notch1 has been gradually revealed, and also demonstrated to affect the proliferation and differentiation of HSCs. Therefore, a detailed elucidation of Notch1 and its ubiquitination modification may help to improve understanding of the maintenance of HSC properties and the pathogenesis of leukemia. In addition, it may aid in identifying potential therapeutic targets for specific leukemias and provide potential prognostic indicators for HSC transplantation (HSCT). In the present review, the association between Notch1 and HSCs and the link between the ubiquitination modification of Notch1 and HSCs were described. In addition, the association between abnormal HSCs mediated by Notch1 or ubiquitinated Notch1and T-cell acute lymphoblastic leukemia (T-ALL) was also examined, which provides a promising direction for clinical application.

show abstract

Section: Clinical Applicationmentioning

confidence: 99%

Section: Clinical Applicationmentioning

confidence: 99%