Resolution of chronic active EBV infection and coexisting pulmonary arterial hypertension after cord blood transplantation

Hyperactivity of the CD155 immune checkpoint suppresses anti-viral immunity in patients with coronary artery disease

“…Poor anti-viral immunity in patients with CAD has been exemplified during the recent SARS-CoV-2 pandemic, where a history of CAD was associated with severe symptoms 1 . Patients with CAD generate weak immune responses against varicella zoster virus 4 , and chronic EBV infection has been associated with cardiovascular disease 5,6 . Although the relationship between viral immunity and progression of atherosclerotic disease remains insufficiently understood, the recent pandemic has made clear that a better understanding of protective immunity is needed to inform therapeutic management of virally infected patients with pre-existent cardiovascular disease.Protection against and clearance of viral pathogens depends on the induction of adaptive immunity-in particular, priming and expansion of CD4 + T cells that help antibody-producing B cells and virus-specific CD8 + killer T cells 7 .…”

“…mRNA modifications are recognized as major post-transcriptional processes determining gene expression 18 . As the most prevalent reversible modification on mRNA, m 6 A regulates transcript stability, alternative splicing and translation 18,19 . Controlled by a group of regulatory proteins subdivided into 'writer' , 'reader' and 'eraser' proteins, m 6 A is relevant for multiple cell types 20 .…”

“…As the most prevalent reversible modification on mRNA, m 6 A regulates transcript stability, alternative splicing and translation 18,19 . Controlled by a group of regulatory proteins subdivided into 'writer' , 'reader' and 'eraser' proteins, m 6 A is relevant for multiple cell types 20 . m 6 A is generated when the METTL3/METTL14/WTAP complex adds a methyl group at position N 6 of adenosine 21 .…”

“…Controlled by a group of regulatory proteins subdivided into 'writer' , 'reader' and 'eraser' proteins, m 6 A is relevant for multiple cell types 20 . m 6 A is generated when the METTL3/METTL14/WTAP complex adds a methyl group at position N 6 of adenosine 21 . In mice, METTL3 deficiency leads to embryonic lethality 22 .…”

Successful Cord Blood Stem Cell Transplantation for an Adult Case of Chronic Active Epstein-Barr Virus Infection

“…In the literature, we found 8 adult (≥20 years old) cases of CAEBV treated with CBT ( Table ) ( 3 , 9 - 12 ). The median age was 38 years (range: 20-56), and engraftment was achieved in 7 cases.…”