Resolution of experimental pneumothorax in rabbits by oxygen therapy

Hill, Ronald C.; DeCarlo, Donald P.; Hill, Jeffrey F.; Beamer, Kathryn C.; Hill, Mandy L.; Timberlake, Gregory A.

doi:10.1016/0003-4975(95)00007-8

Cited by 32 publications

(16 citation statements)

References 4 publications

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“…A randomized clinical trial on 23 rabbits, in whom unilateral pneumothorax was induced, Ronald et al observed [28] that the resolution rate of pneumothorax was shorter (36 hours) in the group that received a higher concentration of oxygen (FiO 2 ≥ 60%), compared to the group that was treated with room air (48 hours) [28]. In two other studies on rabbits by England [29] and Zierold [30], the rate of resolution was dependent on the concentration of oxygen.…”

Section: Discussionmentioning

confidence: 99%

Impact of oxygen concentration on time to resolution of spontaneous pneumothorax in term infants: a population based cohort study

et al. 2014

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BackgroundLittle evidence exists regarding the optimal concentration of oxygen to use in the treatment of term neonates with spontaneous pneumothorax (SP). The practice of using high oxygen concentrations to promote “nitrogen washout” still exists at many centers. The aim of this study was to identify the time to clinical resolution of SP in term neonates treated with high oxygen concentrations (HO: FiO2 ≥ 60%), moderate oxygen concentrations (MO: FiO2 < 60%) or room air (RA: FiO2 = 21%).MethodsA population based cohort study that included all term neonates with radiologically confirmed spontaneous pneumothorax admitted to all neonatal intensive care units in Calgary, Alberta, Canada, within 72 hours of birth between 2006 and 2010. Newborns with congenital and chromosomal anomalies, meconium aspiration, respiratory distress syndrome, and transient tachypnea of newborn, pneumonia, tension pneumothorax requiring thoracocentesis or chest tube drainage or mechanical ventilation before the diagnosis of pneumothorax were excluded. The primary outcome was time to clinical resolution (hours) of SP. A Cox proportional hazards model was developed to assess differences in time to resolution of SP between treatment groups.ResultsNeonates were classified into three groups based on the treatment received: HO (n = 27), MO (n = 35) and RA (n = 30). There was no significant difference in time to resolution of SP between the three groups, median (range 25th-75th percentile) for HO = 12 hr (8–27), MO = 12 hr (5–24) and RA = 11 hr (4–24) (p = 0.50). A significant difference in time to resolution of SP was also not observed after adjusting for inhaled oxygen concentration [MO (a HR = 1.13, 95% CI 0.54-2.37); RA (a HR = 1.19, 95% CI 0.69-2.05)], gender (a HR = 0.87, 95% CI 0.53-1.43) and ACoRN respiratory score (a HR = 0.7, 95% CI 0.41-1.34).ConclusionsSupplemental oxygen use or nitrogen washout was not associated with faster resolution of SP. Infants treated with room air remained stable and did not require supplemental oxygen at any point of their admission.

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Section: Discussionmentioning

confidence: 99%

Impact of oxygen concentration on time to resolution of spontaneous pneumothorax in term infants: a population based cohort study

et al. 2014

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“…In 1954, in clinical conditions, Kircher and Swartzel found that the air in the pleural cavity can be resorbed at a rate of approximately 1.25% of pneumothorax size per 24 hours. 2,3 R. Hill et al 10,11 The aim of the this study was to assess the capabilities of the pleura for air resorption from the pleural space. We hypothesised that in the described experiment, the reabsorption of air from the pleural space will be faster than the one established in clinical conditions (1.25%/day).…”

Section: Discussionmentioning

confidence: 99%

Resolution of Experimental Pneumothorax by Room Air

Novakov¹,

Hadzhigeorgiev²,

Safev³

2011

Folia Medica

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“…Loculated collections are targeted according to their position, which is usually best determined by CT. Our preference is to use a 8±10 Fr catheter introduced by the Seldinger technique, which is connected either to a unidirectional flutter valve (Heimlich) or to wall suction via an underwater seal. Wall suction and oxygen [76] may be used to enhance lung expansion. The catheter should be left in position until drainage is complete and the lung has re-expanded.…”

Section: Pneumothoraxmentioning

confidence: 99%