Resolution of left and right ventricular thrombosis secondary to hypereosinophilic syndrome (lymphoproliferative variant) with reduced intensity conditioning allogenic stem cell transplantation

Molecular profiling of CD3−CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways

“…The CD3 Ϫ CD4 ϩ T cells may eventually become refractory to treatment in parallel with malignant progression, which currently leaves only allogeneic stem cell transplantation as possibly curative. 57 Our earlier work identified a CD3 Ϫ CD4 ϩ T-cell population as the source of Th2 cytokines in a symptomatic L-HES patient. 17 We further demonstrated that the CD3 Ϫ CD4 ϩ T-cell population in patients was monoclonal based on its T-cell receptor rearrangement 2 and that loss of surface TCR/CD3 expression was the result of a defect in CD3␥ gene transcripts.…”

CD3-CD4+ lymphoid variant of hypereosinophilic syndrome: nodal and extranodal histopathological and immunophenotypic features of a peripheral indolent clonal T-cell lymphoproliferative disorder

“…[14][15][16][17][18] PTCLs have also been reported during CD3-CD4 + L-HES course. 6,9,[19][20][21][22][23][24] Two of 23 patients currently followed in the French Eosinophil Network, and one more patient recently reported by others, 25 developed well-defined AITL several years after L-HES diagnosis, which thus raised the problem of the diagnosis of well-defined T-cell lymphoma in patients who have clonal circulating T cells.In this study, we focused on the lymphoid infiltrates in lymph nodes, skin and other available biopsies of tissue involved in L-HES, to assess the presence of clonal T cells at diagnosis and during CD3 - …”

Case Report: Hypereosinophilic Syndrome Response to Infliximab in a Patient with Ulcerative Colitis

“…Treatment with alpha interferon, mepolizumab (anti-IL5), alemtuzumab (anti-CD52) and other chemotherapeutic agents such as cladribine, chlorambucil, vincristine, methotrexate, cyclosporine and etoposide have been evaluated in specific cases. Hematopoietic cell transplantation should be considered as the last therapeutic alternative when everything else has failed [1][2][3][4][5][6][7][8][9][10]. Anti-TNF administration has been reported to induce severe eosinophilic gastroenteritis in a patient with Crohn's Disease [11].…”