Resolution of MoS<sub>2</sub> Nanosheets‐Induced Pulmonary Inflammation Driven by Nanoscale Intracellular Transformation and Extracellular‐Vesicle Shuttles

Peña, Nathaly Ortiz; Cherukula, Kondareddy; Even, Benjamin; Ji, Ding‐Kun; Razafindrakoto, Sarah; Peng, Shiyuan; Silva, Amanda; Ménard‐Moyon, Cécilia; Hillaireau, Hervé; Bianco, Alberto; Fattal, Elias; Alloyeau, Damien; Gazeau, Florence

doi:10.1002/adma.202305230

Cited by 2 publications

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“…In a word, MoS 2 nanosheets underwent oxidation and etching, consuming hydrogen peroxide (H 2 O 2 ) and inducing the stripping of the MoS 2 nanosheets, allowing for more free‐standing sheets rolling and folding which were found to curl to minimize surface energy and exhibit reversibility (Figure 2b,c). [159] …”

Section: Nano‐bio Interactions Between 2d Nanomaterials and Mps Cellsmentioning

confidence: 99%

Section: Nano‐bio Interactions Between 2d Nanomaterials and Mps Cellsmentioning

confidence: 99%

“…(e) LPS caused inflammation regulated by EVs. (f) The inflammatory status of macrophages upon MoS 2 treatment with different concentrations for 24 or 72 h [159] …”

Section: Nano‐bio Interactions Between 2d Nanomaterials and Mps Cellsmentioning

confidence: 99%

“…TMDs can also inhibit the activation of the M1 phenotype and alleviate inflammation. Gazeau's group found that the intracellular biotransformation process (scrolling, etching, and oxidation) of MoS 2 and extracellular‐vesicle shuttles (EVs) response to the treatment of MoS 2 in alveolar macrophages resolved the lung inflammation [159] . On the one hand, EVs released from alveolar macrophages responded to xenobiotics and infection could act as inflammatory mediators (Figure 4e).…”

Section: Nano‐bio Interactions Between 2d Nanomaterials and Mps Cellsmentioning

confidence: 99%

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Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells

Zhao,

Chen,

Liu

et al. 2024

BMEMat

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Two‐dimensional (2D) nanomaterials, known for their unique atomic arrangements and exceptional physicochemical properties, have garnered significant attention in biomedical applications, particularly in the realms of immunotherapy for tissue engineering and tumor therapy. These applications necessitate a thorough assessment of the potential influence of 2D nanomaterials on immune cells. Notably, the mononuclear phagocyte system (MPS) cells, which play pivotal roles in both innate and adaptive immunity, are essential for maintaining organismal homeostasis. MPS cells with phagocytic capability contribute to the prevention of foreign body invasion and the elimination of dead or senescent cells. Furthermore, MPS cells, including macrophages and dendritic cells, serve as vital bridges between innate and adaptive immune responses. Therefore, understanding the nano‐bio interactions between 2D nanomaterials and MPS cells is imperative. These nano‐bio interactions including cellular uptake, cytocompatibility, and immunological impact are invaluable for the purposeful design of 2D nanomaterials. Herein, we provide an overview of the latest advancements in understanding the nano‐bio interactions between 2D nanomaterials and MPS cells, and discuss the current challenges and future prospects of employing 2D nanomaterials in the field of nanomedicine.

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Section: Nano‐bio Interactions Between 2d Nanomaterials and Mps Cellsmentioning

confidence: 99%

Section: Nano‐bio Interactions Between 2d Nanomaterials and Mps Cellsmentioning

confidence: 99%

“…(e) LPS caused inflammation regulated by EVs. (f) The inflammatory status of macrophages upon MoS 2 treatment with different concentrations for 24 or 72 h [159] …”

Section: Nano‐bio Interactions Between 2d Nanomaterials and Mps Cellsmentioning

confidence: 99%

Section: Nano‐bio Interactions Between 2d Nanomaterials and Mps Cellsmentioning

confidence: 99%

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Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells

Zhao,

Chen,

Liu

et al. 2024

BMEMat

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The transcriptome of MHV‐infected RAW264.7 cells offers an alternative model for macrophage innate immunity research

Liu,

Feng,

Tong

et al. 2024

Anim Models and Exp Med

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BackgroundMacrophages are the primary innate immune cells encountered by the invading coronaviruses, and their abilities to initiate inflammatory reactions, to maintain the immunity homeostasis by differential polarization, to train the innate immune system by epigenic modification have been reported in laboratory animal research.MethodsIn the current in vitro research, murine macrophage RAW 264.7 cell were infected by mouse hepatitis virus, a coronavirus existed in mouse. At 3‐, 6‐, 12‐, 24‐, and 48‐h post infection (hpi.), the attached cells were washed with PBS and harvested in Trizol reagent. Then The harvest is subjected to transcriptome sequencing.ResultsThe transcriptome analysis showed the immediate (3 hpi.) up regulation of DEGs related to inflammation, like Il1b and Il6. DEGs related to M2 differential polarization, like Irf4 showed up regulation at 24 hpi., the late term after viral infection. In addition, DEGs related to metabolism and histone modification, like Ezh2 were detected, which might correlate with the trained immunity of macrophages.ConclusionsThe current in vitro viral infection study showed the key innated immunity character of macrophages, which suggested the replacement value of viral infection cells model, to reduce the animal usage in preclinical research.

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Resolution of MoS₂ Nanosheets‐Induced Pulmonary Inflammation Driven by Nanoscale Intracellular Transformation and Extracellular‐Vesicle Shuttles

Cited by 2 publications

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Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells

Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells

The transcriptome of MHV‐infected RAW264.7 cells offers an alternative model for macrophage innate immunity research

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Resolution of MoS2 Nanosheets‐Induced Pulmonary Inflammation Driven by Nanoscale Intracellular Transformation and Extracellular‐Vesicle Shuttles

Cited by 2 publications

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Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells

Nano‐bio interactions between 2D nanomaterials and mononuclear phagocyte system cells

The transcriptome of MHV‐infected RAW264.7 cells offers an alternative model for macrophage innate immunity research

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Resolution of MoS₂ Nanosheets‐Induced Pulmonary Inflammation Driven by Nanoscale Intracellular Transformation and Extracellular‐Vesicle Shuttles