Resolution of N-Protected Amino Alcohols by Porcine Pancreatic Lipase

Kinetic and dynamic kinetic enzymatic resolutions of tetrahydro-ß-carboline and tetrahydroisoquinoline derivatives

“…The effect of N-protecting groups on the PPL-catalysed O-acylation of βamino alcohols [(±)-63a-f] was investigated by Kokotos et al (Scheme 24) [143]. The results showed that the type of the protecting group had a marked effect on the E and reaction rate of the enzymatic resolution, while the side chain of the amino alcohol had a lower impact on the acylation.…”