Resolution of Risperidone-Induced Hyperprolactinemia with Substitution of Quetiapine

Kunwar, Arun Raj; Megna, James L

doi:10.1345/1542-6270(2003)37<206:rorhws>2.0.co;2

Cited by 6 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The lack of prolactin increase following clozapine administration could be due to the sparing of dopamine‐mediated inhibition of the prolactin release and the direct stimulatory effect on TID neurons (Meltzer and Gudelsky, 1992). Additionally, clozapine does not interfere with norepinephrine‐mediated inhibition of prolactin secretion (Lamberts et al, 1990). Clozapine at high concentrations appeared to directly inhibit prolactin release and DNA content of in vitro cultured pituitary tumour cells, suggesting an anti‐mitotic action on the lactotrophs (Lamberts et al, 1990).…”

Section: Antipsychoticsmentioning

confidence: 99%

“…Additionally, clozapine does not interfere with norepinephrine‐mediated inhibition of prolactin secretion (Lamberts et al, 1990). Clozapine at high concentrations appeared to directly inhibit prolactin release and DNA content of in vitro cultured pituitary tumour cells, suggesting an anti‐mitotic action on the lactotrophs (Lamberts et al, 1990). A 6 weeks trial of clozapine therapy was found to reduce hyperprolactinaemia by 16–80% (Goodnick et al, 2002).…”

Section: Antipsychoticsmentioning

confidence: 99%

See 1 more Smart Citation

Hyperprolactinemia associated with psychotropics—a review

Madhusoodanan¹,

Parida

Jimenez

2010

Human Psychopharmacology

112

View full text Add to dashboard Cite

show abstract

Section: Antipsychoticsmentioning

confidence: 99%

Section: Antipsychoticsmentioning

confidence: 99%

Hyperprolactinemia associated with psychotropics—a review

Madhusoodanan¹,

Parida

Jimenez

2010

Human Psychopharmacology

112

View full text Add to dashboard Cite

show abstract

“…In addition, if axillary metastatic lymph nodes are detected, no additional treatment is required. Some studies advocate that the morbidity rates are comparable to levels I and II dissections, and hence the patients do not receive radiotherapy (22). Completely axillary dissection is the most effective strategy to reduce the risk of recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…In a sera of 278 patients who underwent complete axillary dissection, metastases were detected in rotator ganglia and apical lymph nodes in 29 patients (10.4%). (22,23). Considering these residual lymph nodes, it was necessary to apply radiotherapy in cases where levels I and II lymph nodes were removed.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the accuracy of isosulfan blue and technetium-99m lymphoscintigraphy to determine axillary lymph node metastasis in breast cancer

Albuz¹,

Akkurt²,

Ayan³

et al. 2017

Med J Islamic World Acad Sci

View full text Add to dashboard Cite

Breast cancer is the most common malignant neoplasm in women, accounting for nearly 31% of all female cancers (1-3). Most patients in developed countries are diagnosed with stages I and II, of which about 65% have no axillary lymph node (ALN) metastasis (4). However, complications such as edema, seroma, injuries of veins and nerves passing through ALN, limitation of arm movements, and pain are noted (5-7). The presence and number of axillary metastatic lymph nodes are the most important prognostic factors in breast cancer (4-7). The results of clinical evaluation of the axillary region are often misleading in approximately one third of patients (7-11). It was determined in 1930 that the lymphatic drainage of the primary tumor was directed to a focal point, from where it spread to other lymph nodes. This first station of lymph node metastasis was called sentinel lymph node (SLN) (12,13). Systematic studies of breast cancer have shown that cancer spreads to one or more SLNs before spreading to other ALNs (14,15). The present study aimed to evaluate axillary sentinal lymph node metastasis for breast cancer diagnosis. The effectiveness of technetium-99 m sulfur colloid, isosulfan blue (ISB), and concomitant use of technetium-99 m sulfur colloid and ISB was compared. SUMMARYThis study aimed to compare the efficiency of isosulfan blue (ISB) and colloid methods in determining metastatic conditions of axillary lymph node in sentinel lymph node biopsy (SLNB). This prospective study was performed between A total of 102 female patients diagnosed with breast cancer were enrolled in the clinic of Gulhane School of Medicine. According to the diagnostic protocols of SLN, the patients were divided into three groups as follows: ISB (group I), colloid (group II), and ISB and colloid (group III). SLN was identified in 49 of 52 patients (94.2%) in the ISB group; the sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and false negativity (FN) ratio were found to be 90.9%, 75.8%, 96.1%, 55.5%, and 9.1%, respectively. On the contrary, the sentinel lymph node was identified in 38 of 38 (100%) patients in the colloid group; the sensitivity, specificity, PPV, NPV, and FN were found to be 88.2%, 100%, 100%, 91.3%, and 11.8%, respectively. In ISB and colloid groups; SLN was identified in 12 of 12 (100%) patients in the ISB and colloid groups; the sensitivity, specificity, PPV, NPV, and FN were found to be 100%, 100%, 100%, and 0%, respectively. This study showed that the combined methods applied to heterogeneous groups of patients for SLNB in breast cancer cases were minimally invasive and effective and hence could be used for evaluating nodal metastases.

show abstract

“…With the exception of risperidone, amisulpride and molindone, which are often associated with high PRL levels (45), most of the AAPs elicit a poor hyperprolactinemic response or no hyperprolactinemia at all (43,45,46). Furthermore, the use of drugs such as quetiapine and aripiprazole (a dopamine partial agonist) was shown to be associated with resolution of the hyperprolactinemia induced by other AAPs (48). Moreover, decreased PRL levels were also reported when aripiprazole was used as adjunct therapy to risperidone (49).…”

Section: How Do Prl Levels Behave In Cases Of Druginduced Hyperprolacmentioning

confidence: 99%

Controversial issues in the management of hyperprolactinemia and prolactinomas – An overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism

Vilar¹,

Abucham²,

Albuquerque³

et al. 2018

Archives of Endocrinology and Metabolism

102

View full text Add to dashboard Cite

Prolactinomas are the most common pituitary adenomas (approximately 40% of cases), and they represent an important cause of hypogonadism and infertility in both sexes. The magnitude of prolactin (PRL) elevation can be useful in determining the etiology of hyperprolactinemia. Indeed, PRL levels > 250 ng/mL are highly suggestive of the presence of a prolactinoma. In contrast, most patients with stalk dysfunction, drug-induced hyperprolactinemia or systemic diseases present with PRL levels < 100 ng/mL. However, exceptions to these rules are not rare. On the other hand, among patients with macroprolactinomas (MACs), artificially low PRL levels may result from the so-called "hook effect". Patients harboring cystic MACs may also present with a mild PRL elevation. The screening for macroprolactin is mostly indicated for asymptomatic patients and those with apparent idiopathic hyperprolactinemia. Dopamine agonists (DAs) are the treatment of choice for prolactinomas, particularly cabergoline, which is more effective and better tolerated than bromocriptine. After 2 years of successful treatment, DA withdrawal should be considered in all cases of microprolactinomas and in selected cases of MACs. In this publication, the goal of the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism (SBEM) is to provide a review of the diagnosis and treatment of hyperprolactinemia and prolactinomas, emphasizing controversial issues regarding these topics. This review is based on data published in the literature and the authors' experience.

show abstract

Resolution of Risperidone-Induced Hyperprolactinemia with Substitution of Quetiapine

Cited by 6 publications

References 0 publications

Hyperprolactinemia associated with psychotropics—a review

Hyperprolactinemia associated with psychotropics—a review

Comparison of the accuracy of isosulfan blue and technetium-99m lymphoscintigraphy to determine axillary lymph node metastasis in breast cancer

Controversial issues in the management of hyperprolactinemia and prolactinomas – An overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism

Contact Info

Product

Resources

About