Resolution of Serologic Problems Due to Cold Agglutinins in Chronic Lymphocytic Leukemia

Javed, Rizwan; Datta, Suvro Sankha; Basu, Sabita; Chakrapani, Anupam

doi:10.1007/s12288-016-0644-4

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Cold agglutinins can also interfere with laboratory tests. Several case studies have reported that cold antibodies caused erroneous laboratory results, especially in the complete blood count (CBC) and blood group test [2,3]. In the present case, in addition to the CBC, unexpected haptoglobin (Hp) and glycated hemoglobin (HbA1c) results were reported.…”

mentioning

confidence: 54%

Unexpected laboratory results in cold agglutinin disease

Yaşar¹,

Özgenç²,

Bolayirli³

et al. 2018

Int J Med Biochem

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mentioning

confidence: 54%

Unexpected laboratory results in cold agglutinin disease

Yaşar¹,

Özgenç²,

Bolayirli³

et al. 2018

Int J Med Biochem

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“…It is worth recommending to perform the test with monospecific antisera and to determine the presence of IgG and/or complement on red blood cells (RBCs) [29]. In AIHA, three patterns of reactivity may be found on a direct antiglobulin test: IgG alone, complement alone, or both.…”

Section: Clinical Applications Of Dat Diagnosis and Classification Of Autoimmune Hemolytic Anemiamentioning

confidence: 99%

Clinical applications of direct antiglobulin test

Lin¹

2018

Blood Heart Circ

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The direct antiglobulin test (DAT) is used to detect immunoglobulin and/or complement on the surface of red blood cells (RBCs). The DAT is valuable in the investigation of autoimmune hemolytic anemia, drug-induced immune hemolysis, hemolytic disease of newborn, hemolytic transfusion reactions, and passenger lymphocyte syndrome. There are several limitations of DAT, such as sensitivity, false positive and false negative. The patient's clinical history, diagnoses, and other laboratory test results should also take into consideration for DAT interpretation.

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“…Several case studies have reported that cold antibodies cause erroneous laboratory results, especially in the (FBC) and blood group test. [2][3] In such cases the cold antibody IgM being cold agglutinin's could be detected by just warming the tube at desired temperature (i-e37⁰c). Cold antibodies are usually immunoglobulin IgM type antibodies which are against the I/i carbohydrate antigens on the surface of red cells.…”

Section: Introductionmentioning

confidence: 99%

Cold antibodies association with cellulitis, deep vein thrombosis and abnormal red cells indices: A Case Report.

Faiz¹,

Bashir

Ghazanfer

et al. 2020

TPMJ

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Objectives: To provide awareness to the pathologists and technologists all about the red cells parameters in cold antibodies concerned cases. Case Report Findings: A sixty seven-years-old male admitted in emergency department of our hospital, having clinical history of swelling and pain in both the lower limb and feet, on physical examination, provisionally diagnosed as a case of Cellulitis and deep vein thrombosis(DVT). Blood specimen was obtained for general hematological investigations. Full blood count (FBC) was performed on sysmex XP-100 hematological analyzer which showed invalid findings especially red cells indices which were not corresponding to the hemoglobin (Hb) concentration of the patient. Blood sample was repeated, to confirm invalid red cells indices which showed values as in the 1st blood specimen. Blood smears revealed aggregation of red cells. By warming the ethylenediamine tetra-acetic acid (EDTA) tube containing the blood specimen, in water bath at 37⁰C for one hour and repeated the FBC on hematological analyzer and found the corrected red cells indices. Conclusion: Basic knowledge of cold antibodies and warming the blood sample at 37⁰c for one hour helps the correct diagnosis.

show abstract

Resolution of Serologic Problems Due to Cold Agglutinins in Chronic Lymphocytic Leukemia

Cited by 5 publications

References 7 publications

Unexpected laboratory results in cold agglutinin disease

Unexpected laboratory results in cold agglutinin disease

Clinical applications of direct antiglobulin test

Cold antibodies association with cellulitis, deep vein thrombosis and abnormal red cells indices: A Case Report.

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