Resolution of superior oblique myokymia with memantine

Jain, Saurabh; Farooq, S.J.; Gottlob, Irène

doi:10.1016/j.jaapos.2007.07.007

Cited by 17 publications

(9 citation statements)

References 11 publications

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“…Effective treatment of SOM with Gabapentin has been reported before but vascular compression was not documented in those reports. [12][13][14][15] This is the first case report documenting successful treatment of SOM with Gabapentin in a patient with vascular compression on imaging. The exact mechanism of gabapentin on SOM is unclear and it is possible that neurotransmitter systems other than GABAergic ones may be involved.…”

Section: Discussionmentioning

confidence: 80%

Gabapentin and Superior Oblique Myokymia

Bek

Kaşikçi

Genç

et al. 2009

Neuro-Ophthalmology

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Superior oblique myokymia (SOM) is an uncommon disorder characterized by episodic monocular oscillopsia. Though the mechanism of SOM is not fully established, recent reports focus on the role of vascular compression. Several medications have been reported to be of benefit but a standard protocol for SOM has not been established. This case report documents a complete symptom relief in SOM with a documented vascular compression using gabapentin.

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Section: Discussionmentioning

confidence: 80%

Gabapentin and Superior Oblique Myokymia

Bek

Kaşikçi

Genç

et al. 2009

Neuro-Ophthalmology

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“…Other medications, such as benzodiazepines, have been tried with no consistent benefit 3. Memantine, which is an N‐methyl‐ D ‐aspartate receptor antagonist with similar antiglutaminergic action as gabapentin, has also been reported to successfully treat isolated superior oblique myokymia with good success 6. The use of botulinum toxin A has previously been reported in the treatment of isolated orbicularis oculi muscle myokymia with good results 7.…”

Section: Discussionmentioning

confidence: 99%

Isolated laryngeal myokymia: Diagnosis and treatment

Sedgh¹,

Statham²,

Munin³

et al. 2010

The Laryngoscope

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Myokymia is an uncommon neuromuscular disorder that rarely affects the human larynx. No previous reports of isolated laryngeal myokymia are present in the literature, and as such, established treatment protocols are lacking. We report the first case of isolated laryngeal myokymia in a 48-year-old woman with no other neurological findings, and our successful results in initial treatment and maintenance therapy with focal intralaryngeal injections of botulinum toxin A.

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“…Medical treatment options include oral carbemazepine, phenytoin sodium, clonazepam, baclofen, gabapentin and propranolol, and topical beta-blockers (Timolol maleate, betaxolol), all of which have been reported to have variable success. [5][6][7][8][9][10][27][28][29] In some patients treatment was not successful; in others the benefit was temporary, and numerous patients did not tolerate the medication due to side effects. Carbamazepine is the most frequently reported medication used followed by topical beta-blockers.…”

Section: Discussionmentioning

confidence: 99%