Resolution of the expert panel «Optimization of care for patients with ischemic stroke at all stages of medical rehabilitation»

Вознюк, И А; Zalyalova, Z. A.; Захаров, Д. В.; Ivanova, Galina E.; Костенко, Е. В.; Krasavina, D.A.; Orlova, Olga; Похабов, Д. В.; Хасанова, Д. Р.; Khatkova, Svetlana; Shikhkerimov, R. K.

doi:10.17116/jnevro2023123051181

Z. nevrol. psikhiatr. im. S.S. Korsakova

2023

DOI: 10.17116/jnevro2023123051181

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Resolution of the expert panel «Optimization of care for patients with ischemic stroke at all stages of medical rehabilitation»

И А Вознюк¹,

Z. A. Zalyalova²,

Д. В. Захаров³

et al.

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2024

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Neuroprotective action of hydroxybenzoic acid derivative with glycine (C40) in the middle cerebral artery occlusion in rats with chronic cerebral circulation insufficiency

Verkholyak,

Bakulin,

Brel

et al. 2024

Journal of Volgograd State Medical University

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The neuroprotective effect of a novel conjugate of hydroxybenzoic acid with glycine (C40) was investigated in a model of ischemic stroke in rats with chronic cerebral circulation insufficiency (CCCI). The study was conducted in two stages: first, CCCI was modeled by stenosing the common carotid arteries by 50 %, followed by a 60-minute middle cerebral artery occlusion (stroke) after 40 days. Compound C40 and the reference drug citicoline were administered for 10 days before stroke and for 3 days after. Further, neurological deficit (the Garcia and Combs D’Alecy scales), sensorimotor functions (Open Field test, Adhesive Removal test, and Rotarod test), cognitive impairments (Novel Object Recognition and Morris Water Maze tests), cerebral blood flow level, and endothelial function were evaluated. Animals receiving the test substances demonstrated a statistically significant reduction in neurological deficit, less pronounced motor coordination and sensorimotor function impairments, as well as fewer short-term and long-term memory deficits compared to the negative control group. The observed decrease in neurological deficit in the experimental groups was accompanied by improved endothelial function and increased cerebral blood flow. The neuroprotective effect of the novel hydroxybenzoic acid derivative with glycine (C40) was comparable to that of reference drug citicoline.

show abstract

Neuroprotective action of hydroxybenzoic acid derivative with glycine (C40) in the middle cerebral artery occlusion in rats with chronic cerebral circulation insufficiency

Verkholyak,

Bakulin,

Brel

et al. 2024

Journal of Volgograd State Medical University

View full text Add to dashboard Cite

show abstract

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Resolution of the expert panel «Optimization of care for patients with ischemic stroke at all stages of medical rehabilitation»

Cited by 1 publication

References 0 publications

Neuroprotective action of hydroxybenzoic acid derivative with glycine (C40) in the middle cerebral artery occlusion in rats with chronic cerebral circulation insufficiency

Neuroprotective action of hydroxybenzoic acid derivative with glycine (C40) in the middle cerebral artery occlusion in rats with chronic cerebral circulation insufficiency

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