Resolved: Low‐dose prednisone is indicated as a standard treatment in patients with rheumatoid arthritis

Conn, Doyt L.

doi:10.1002/1529-0131(200110)45:5<462::aid-art366>3.0.co;2-v

Cited by 40 publications

(32 citation statements)

References 23 publications

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“…Fewer than half of the long-term glucocorticoid users we studied underwent any form of bone mass measurement. Approximately one-third of the cohort was not taking OTC calcium supplements, and one-fourth of the individuals taking prescription antiresorptive medications were not taking calcium or vitamin D. In light of the wide availability of effective therapies to prevent and treat glucocorticoid-induced osteoporosis, some believe the incidence of fractures should be significantly attenuated (19). However, our results suggest that insufficient glucocorticoid-induced osteoporosis screening and preventive treatment remains a barrier to this potentially achievable goal.…”

Section: Discussionmentioning

confidence: 84%

Longitudinal patterns in the prevention of osteoporosis in glucocorticoid‐treated patients

Curtis¹,

Westfall²,

Allison³

et al. 2005

Arthritis & Rheumatism

137

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Objective. To evaluate patient and physician factors associated with prevention of glucocorticoidinduced osteoporosis and to describe temporal trends in screening and prevention of glucocorticoid-induced osteoporosis.Methods. Using databases from a national managed care organization, enrollees who had been prescribed glucocorticoids (taken for at least 60 days) during an 18-month period were identified. Administrative data from January Conclusion. Despite significant temporal increases in the frequency of screening for and treatment of glucocorticoid-induced osteoporosis, absolute rates remain low, especially among men, African Americans, and patients of certain physician specialties.Glucocorticoids are prescribed widely in medical practice and are used by 0.5-2.5% of adults (1,2). Despite the acknowledged benefits of glucocorticoid treatment in controlling short-term inflammation, concerns about associated adverse events often limit its use. Among the most feared is glucocorticoid-induced osteoporosis. Rates of glucocorticoid-induced osteoporosisassociated fracture may approach 40% in selected populations (3,4), and this condition often results in

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Section: Discussionmentioning

confidence: 84%

Longitudinal patterns in the prevention of osteoporosis in glucocorticoid‐treated patients

Curtis¹,

Westfall²,

Allison³

et al. 2005

Arthritis & Rheumatism

137

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“…About eighty percent of the RA patients in our study were on corticosteroids (Table 1). Corticosteroids have anti inflammatory activities by inhibiting proinflammatory proteins as cyclooxygenase 2, IL-1, IL-2 and IL-6, tumour necrosis factor alpha and adhesion molecules 36 . About three-quarter of our RA patients used NSAIDs which have anti-inflammatory activity inhibiting cyclooxygenase, an enzyme that catalyzes the conversion of arachidonic acid to prostaglandins and tromboxanes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Susanto

Nesse

Kertia

et al. 2013

Journal of Periodontology

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Background: Patients with rheumatoid arthritis (RA) may have more prevalent and severe periodontitis than healthy controls. Periodontitis may increase the systemic inflammation in RA. The aim of this study is to assess periodontitis prevalence and severity and its potential association with systemic inflammation in Indonesian patients with RA.Methods: A full‐mouth periodontal examination including probing depth, gingival recession, plaque index, and bleeding on probing was performed in 75 Indonesians with RA and 75 age‐, sex‐, and smoking‐matched Indonesian controls. A validated questionnaire was used to assess smoking, body mass index, education, and medical conditions. In addition, in all participants, the use of drugs was noted, and erythrocyte sedimentation rates and serum levels of high‐sensitivity C‐reactive protein (hsCRP), rheumatoid factor, and anti‐citrullinated protein antibodies were measured. Differences in periodontitis prevalence and 12 measures of periodontitis severity between patients with RA and controls were analyzed using univariate analyses.Results: No significant differences in periodontitis prevalence and 11 measures of periodontitis severity between patients with RA and controls were observed. Conversely, patients with RA had a significantly lower surface area of healthy pocket epithelium versus controls (P = 0.008), and a tendency toward higher hsCRP levels was observed in patients with RA with severe periodontitis compared with patients with RA with no mild or moderate periodontitis (P = 0.063). It has to be noted that all patients with RA were on anti‐inflammatory drugs, whereas none of the controls used such drugs.Conclusion: Prevalence and severity of periodontitis in Indonesian patients with RA is comparable to controls but with less healthy pocket epithelium than in controls and a tendency toward a higher inflammatory state in patients with RA and severe periodontitis.

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“…Glucocorticoids are among the most potent anti-inflammatory and immunosuppressive agents and are key therapeutic agents for the management of chronic inflammatory diseases, including rheumatic diseases [1][2][3][4], pulmonary disease [5;6], asthma [7][8][9][10][11] and post transplantation immunotherapy [12]. However, long-term glucocorticoid therapy (>3 months) causes bone loss resulting in osteoporosis (glucocorticoid-induced osteoporosis or GIOP) [3;4;13-15], a severe-side effect that occurs in 30 -50% of patients [16][17][18].…”

Section: Glucocorticoids and Osteoporosismentioning

confidence: 99%

Mechanism of Glucocorticoid-Induced Osteoporosis: An Update

Shi¹,

Chutkan²,

Hamrick³

et al. 2012

Glucocorticoids - New Recognition of Our Familiar Friend

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Resolved: Low‐dose prednisone is indicated as a standard treatment in patients with rheumatoid arthritis

Cited by 40 publications

References 23 publications

Longitudinal patterns in the prevention of osteoporosis in glucocorticoid‐treated patients

Longitudinal patterns in the prevention of osteoporosis in glucocorticoid‐treated patients

Prevalence and Severity of Periodontitis in Indonesian Patients With Rheumatoid Arthritis

Mechanism of Glucocorticoid-Induced Osteoporosis: An Update

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