We prove essential self-adjointness of Dirac operators with Lorentz scalar potentials which grow sufficiently fast near the boundary ∂ of the spatial domain ⊂ R d . On the way, we first consider general symmetric first order differential systems, for which we identify a new, large class of potentials, called scalar potentials, ensuring essential self-adjointness. Furthermore, using the supersymmetric structure of the Dirac operator in the two dimensional case, we prove confinement of Dirac particles, i.e. essential self-adjointness of the operator, solely by magnetic fields B assumed to grow, near ∂ , faster than 1/ 2dist(x, ∂ ) 2 .
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