Resolvin D1 Ameliorates Nicotinamide-streptozotocin-induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K/Akt/mTOR Pathway in the Brain

Bathina, Siresha; Gundala, Naveen K.V.; Rhenghachar, Poorani; Polavarapu, Sailaja; Hari, Anasuya D.; Sadananda, Monika; Das, Undurti N.

doi:10.1016/j.arcmed.2020.05.002

Cited by 53 publications

(40 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, resolvins, protectins and maresins may be inadequate to trigger efficient inflammation resolution process even though they are anti-inflammatory compounds. It is noteworthy that LXA4 generation is enhanced by resolvins [12] , [13] . This implies that resolvins, protectins and maresins may enhance the formation of LXA4 to resolve inflammation.…”

Section: Efas and Their Metabolites In Covid-19mentioning

confidence: 99%

“…Resolvin E1 has actions similar to LXA4 and suppresses IL-23 and IL-17 production in addition to its ability to inhibit IL-6 and TNF-α. Resolvin E1 promotes LXA4 production [13] , [25] suggesting that a crosstalk occurs between n-3 and n-6 fatty acids’ metabolism.…”

Section: Aa Is Critical For Inflammation Resolutionmentioning

confidence: 99%

“…The proposal by Torrinhas et al [5] is interesting but fails to consider the critical role of AA and its products PGE2 and LXA4 in inflammation and its resolution. Resolvins, protectins and maresins are certainly important in the resolution of inflammation 11 , 12 , 13 , 14 , 15 , 16 . But the resolution of inflammation would not occur without optimal inflammation in the first place.…”

Section: Conclusion and Therapeutic Implicationsmentioning

confidence: 99%

See 2 more Smart Citations

Essential fatty acids and their metabolites in the pathobiology of (coronavirus disease 2019) COVID-19

Das¹

2021

Nutrition

Self Cite

View full text Add to dashboard Cite

Section: Efas and Their Metabolites In Covid-19mentioning

confidence: 99%

Section: Aa Is Critical For Inflammation Resolutionmentioning

confidence: 99%

Section: Conclusion and Therapeutic Implicationsmentioning

confidence: 99%

See 1 more Smart Citation

Essential fatty acids and their metabolites in the pathobiology of (coronavirus disease 2019) COVID-19

Das¹

2021

Nutrition

Self Cite

View full text Add to dashboard Cite

“… Hellmann et al (2011) demonstrated that RvD1 improved glucose tolerance and increased insulin-stimulated pAkt level in liver, adipose tissue and skeletal muscle in db/db mice. The authors further found that RvD1 increased the ratio of M2 and M1 adipose-tissue macrophages ( Bathina et al, 2020 ) and ameliorated adipose tissue inflammation ( Hellmann et al, 2011 ). RvD1 was also reported to improve insulin resistance through the PI3K-Akt-mTOR axis in brain tissue ( Bathina et al, 2020 ).…”

Section: Effect Of ω-3 Pufa-derived Oxylipins On Diabetesmentioning

confidence: 92%

Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders

2021

View full text Add to dashboard Cite

Arachidonic acid (ARA) is an important ω-6 polyunsaturated fatty acid (PUFA), and docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and n-3 docosapentaenoic acid (n-3 DPA) are three well-known ω-3 PUFAs. These fatty acids can be metabolized into a number of bioactive lipids. Eicosanoids derived from ARA have drawn great attention because of their important and complex biofunctions. Although EPA, DHA and n-3 DPA have also shown powerful biofunctions, we have fewer studies of metabolites derived from them than those from ARA. Recently, growing research has focused on the bioaction of ω-3 PUFA-derived metabolites, which indicates their great potential for treating metabolic disorders. Most of the functional studies of these bioactive lipids focused on their anti-inflammatory effects. However, several studies elucidated their direct effects on pancreatic β cells, hepatocytes, adipocytes, skeletal muscle cells, and endothelial cells. These researches revealed the importance of studying the functions of metabolites derived from ω-3 polyunsaturated fatty acids other than themselves. The current review summarizes research into the effects of ω-3 PUFA-derived oxylipins on metabolic disorders, including diabetes, non-alcoholic fatty liver disease, adipose tissue dysfunction, and atherosclerosis.

show abstract

“…In vitro, RvD1 promotes macrophage phagocytosis of Aβ and inhibits apoptosis through GPR32 [117,118]. Recent studies showed that RvD1 promotes the phagocytosis of Aβ by modulating MEK1/2, PKA, and PI3K/Akt/mTOR pathways, which are responsible for supporting cell survival upon exposure to oxidative stress [117,133].…”

Section: Rvd1 (Resolvin D1)mentioning

confidence: 99%

Alzheimer’s Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?

Miyazawa

Fukunaga

Tatewaki

et al. 2020

IJMS

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a common neurodegenerative disease and a major contributor to progressive cognitive impairment in an aging society. As the pathophysiology of AD involves chronic neuroinflammation, the resolution of inflammation and the group of lipid mediators that actively regulate it—i.e., specialized pro-resolving lipid mediators (SPMs)—attracted attention in recent years as therapeutic targets. This review focuses on the following three specific SPMs and summarizes their relationships to AD, as they were shown to effectively address and reduce the risk of AD-related neuroinflammation: maresin 1 (MaR1), resolvin D1 (RvD1), and neuroprotectin D1 (NPD1). These three SPMs are metabolites of docosahexaenoic acid (DHA), which is contained in fish oils and is thus easily available to the public. They are expected to become incorporated into promising avenues for preventing and treating AD in the future.

show abstract

Resolvin D1 Ameliorates Nicotinamide-streptozotocin-induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K/Akt/mTOR Pathway in the Brain

Cited by 53 publications

References 42 publications

Essential fatty acids and their metabolites in the pathobiology of (coronavirus disease 2019) COVID-19

Essential fatty acids and their metabolites in the pathobiology of (coronavirus disease 2019) COVID-19

Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders

Alzheimer’s Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?

Contact Info

Product

Resources

About