Resolvin E1 reduces hepatic fibrosis in mice with Schistosoma japonicum infection

Qiu, Wenhong; Guo, Kaiwen; Yi, Lingling; Gong, Yeli; Huang, Lijuan; Zhong, Wei

doi:10.3892/etm.2014.1641

Cited by 27 publications

(24 citation statements)

References 19 publications

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“…Proteins HA, LN and PC III are important biomarkers of hepatic fibrogenesis [ 30 , 31 ]. Hydroxyproline in liver is an important index whose level reflects the amount of collagen and therefore it can be used to determine the extent of fibrosis [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats

Wei

Fang

Yang

et al. 2015

BMC Complement Altern Med

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BackgroundLiver fibrosis is a feature in the majority of chronic liver diseases and oxidative stress is considered to be its main pathogenic mechanism. Antioxidants including vitamin E, are effective in preventing liver fibrogenesis. Several plant-drived antioxidants, such as silymarin, baicalin, beicalein, quercetin, apigenin, were shown to interfere with liver fibrogenesis. The antioxidans above are polyphenols, flavonoids or structurally related compounds which are the main chemical components of Pomegranate peels and seeds, and the antioxidant activity of Pomegranate peels and seeds have been verified. Here we investigated whether the extracts of pomegranate peels (EPP) and seeds (EPS) have preventive efficacy on liver fibrosis induced by carbon tetrachloride (CCl4) in rats and explored its possible mechanisms.MethodsThe animal model was established by injection with 50 % CCl4 subcutaneously in male wistar rats twice a week for four weeks. Meanwhile, EPP and EPS were administered orally every day for 4 weeks, respectively. The protective effects of EPP and EPS on biochemical metabolic parameters, liver function, oxidative markers, activities of antioxidant enzymes and liver fibrosis were determined in CCl4-induced liver toxicity in rats.ResultsCompared with the sham group, the liver function was worse in CCl4 group, manifested as increased levels of serum alanine aminotransferase, aspartate aminotransferase and total bilirubin. EPP and EPS treatment significantly ameliorated these effects of CCl4. EPP and EPS attenuated CCl4–induced increase in the levels of TGF-β1, hydroxyproline, hyaluronic acid laminin and procollagen type III. They also restored the decreased superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and inhibited the formation of lipid peroxidized products in rats treated with CCl4.ConclusionThe EPP and EPS have protective effects against liver fibrosis induced by CCl4, and its mechanisms might be associated with their antioxidant activity, the ability of decreasing the level of TGF-β1 and inhibition of collagen synthesis.

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Section: Discussionmentioning

confidence: 99%

Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats

Wei

Fang

Yang

et al. 2015

BMC Complement Altern Med

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“…Resolvins, a family of endogenous lipid mediators derived from ω-3 polyunsaturated fatty acid, has been generated from EPA and DHA of fish oil. This family of lipid mediators include resolvin E and D, showing obvious potency in treating hepatic fibrosis in mice with infection, liver cirrhosis or neurodegenerative disorders (11), especially for the disease conditions associated with inflammation. Importantly, various studies showed that resolvins have an ability to perform potent anti-inflammatory actions in obesity-induced liver disease (19).…”

Section: Discussionmentioning

confidence: 99%

“…Resolvins, an anti-inflammatory and endogenous lipid mediator family, have been reported to play an important role in the treatment of many diseases. Resolvin D1 and resolvin E1 (RvD1/RvE1) are compounds that are made by the human body from the ω-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (9)(10)(11). They are increasingly and continuously generated by COX-2 pathway especially in the presence of aspirin.…”

Section: Introductionmentioning

confidence: 99%

Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-κB activity

et al. 2015

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Resolvins, an endogenous lipid mediator derived from eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) of fish oil, has been reported to have anti-inflammatory and antitumor effect in various pathogenic processes. However, there are no studies about the effects of resolvin D1 and E1 on concanavalin A-induced hepatitis. Hence, the present study is to illustrate whether resolvin D1 and E1 inhibit concanavalin A-induced liver injury, liver cancer and underlying mechanisms by which they may recover. C57BL/6 mice were pretreated with resolvin D1 and E1 for 4 h, and then injected with concanavalin A for 12 h. Subsequently, blood and liver tissue were collected at 0, 2, 4, 8 and 12 h for different analysis. Analysis of inflammatory cytokines indicated that the inhibition of necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-2, IL-1β and IL-6 could be performed by resolvin D1 and E1. Moreover, Toll-like receptor (TLR) 4 expression, NF-κB and AP-1 activity also have been confirmed to have key roles in the development of liver injury. They were significantly suppressed in the treatment group, compared to model. In addition, resolvin D1 and E1 markedly downregulated CD4+ and CD8+ cell infiltration in the liver. A long-term concanavalin A treatment for 32 weeks was performed to analyze the changes of hepatitis to liver cancer and the antitumor effect of resolving D1 and E1. These results indicated that resolvin D1 and E1 prevent concanavalin A-induced liver injury and the changes of hepatitis to liver cancer in mice through inhibition of inflammatory cytokine secretion and NF-κB/AP-1 activity. Thus, they could be novel target to be considered in the process of finding sufficient drug to protect against various forms of hepatitis and liver cancer.

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“…A temporal lipid mediator class switch leads to the production of the LXs (34) and also involves phospholipases (35) and the Rvs, which give signals to macrophages and the nonphlogistic recruitment of monocytes (36,37), as they eat and take up the apoptotic neutrophils via phagocytosis (38). When added back pharmacologically, Rvs and other SPMs, such as the PDs regulate inflammatory mediators by counterregulation [TNFa, platelet activating factor (PAF), PGs, LTs, chemokines, and cytokines] to head off inflammation in animal models (see Table 2 for recent preclinical models) as well as organ fibrosis (39)(40)(41)(42). The MaRs and RvE1 were first recognized (43,44) to stimulate resolution, tissue regeneration, and subsequent wound healing (21,45).…”

Section: Alpha Signals Omega In the Cascadementioning

confidence: 99%

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

2017

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Practitioners of ancient societies from the time of Hippocrates and earlier recognized and treated the signs of inflammation, heat, redness, swelling, and pain with agents that block or inhibit proinflammatory chemical mediators. More selective drugs are available today, but this therapeutic concept has not changed. Because the acute inflammatory response is host protective to contain foreign invaders, much of today's pharmacopeia can cause serious unwanted side effects, such as immune suppression. Uncontrolled inflammation is now considered pathophysiologic and is associated with many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity, and asthma, as well as classic inflammatory diseases (, arthritis and periodontal diseases). The inflammatory response, when self-limited, produces a superfamily of chemical mediators that stimulate resolution of the response. Specialized proresolving mediators (SPMs), identified in recent years, are endogenous mediators that include the n-3-derived families resolvins, protectins, and maresins, as well as arachidonic acid-derived (n-6) lipoxins, which promote resolution of inflammation, clearance of microbes, reduction of pain, and promotion of tissue regeneration novel mechanisms. Aspirin and statins have a positive impact on these resolution pathways, producing epimeric forms of specific SPMs, whereas other drugs can disrupt timely resolution. In this article, evidence from recent human and preclinical animal studies is reviewed, indicating that SPMs are physiologic mediators and pharmacologic agonists that stimulate resolution of inflammation and infection. The findings suggest that it is time to challenge current treatment practices-namely, using inhibitors and antagonists alone-and to develop immunoresolvents as agonists to test resolution pharmacology and their role in catabasis for their therapeutic potential.-Serhan, C. N. Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms.

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Resolvin E1 reduces hepatic fibrosis in mice with Schistosoma japonicum infection

Cited by 27 publications

References 19 publications

Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats

Protective effects of extracts from Pomegranate peels and seeds on liver fibrosis induced by carbon tetrachloride in rats

Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-κB activity

Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

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