Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective

Hanganu‐Opatz, Ileana L.; Klausberger, Thomas; Sigurdsson, Torfi; Nieder, Andreas; Jacob, Simon N.; Bartos, Marlene; Sauer, Jonas‐Frederic; Durstewitz, Daniel; Leibold, Christian; Diester, Ilka

doi:10.1016/j.neuron.2023.03.017

Cited by 23 publications

(5 citation statements)

References 219 publications

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“…A neurophysiological study reported the relationship and dynamics between the hippocampus and mPFC interactions. The HPC-PFC circuit has a fundamental role in emotional function and decision-making [15].…”

Section: Discussionmentioning

confidence: 99%

“…The hippocampal formation and mPFC have well-established roles in memory encoding and retrieval. The HPC-mPFC circuit has a fundamental role in cognitive functions such as short-term and long-term memory, attention, and decision-making, which are affected in several neurological diseases [10,[14][15][16]. During spontaneous behavior, functional connectivity between the HPC and mPFC can be inferred from electrophysiological recordings of spike activity and LFPs [9,16].…”

Section: Introductionmentioning

confidence: 99%

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Changes in theta and gamma oscillations of the medial prefrontal cortex following hippocampal-focused ultrasound stimulation

Baek,

Seo,

Kim

et al. 2024

Neurofunction

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Objective: Neuromodulation is a rapidly growing field of treatment, encompassing implantable and noninvasive technology-based approaches. Focused ultrasound (FUS), a noninvasive method, has the potential to modulate neural activity in deep brain regions with spatial precision based on the penetrance of sound waves into the bone and soft tissue. However, neuromodulation is limited by the inability to confirm modulation in real-time. Electrophysiological technology is required to overcome this limitation. In this study, we aimed to confirm neural activity using Neuropixel electrodes during FUS sonication. Methods: Six male C57BL/6 mice were subjected to ultrasound sonication in the hippocampus. Simultaneously, local field potential (LFP) measurements were performed using Neuropixel electrodes. The experimental groups were divided into three categories: before, during, and after FUS sonication and the measured LFP data were compared between groups. Results: Theta and gamma waves were extracted from the recorded LFP data and compared between the groups. The theta and gamma oscillations changed after FUS sonication compared to before. The theta graph showed significant changes between the pre-and during-treatment groups and between the duringand post-treatment groups (theta: 4-8 Hz, F=23.91, p<0.0001). However, the gamma graph did not show significant changes in any groups (gamma: 30-50 Hz). Additionally, the expression of c-fos, a marker of neuronal activity, increased after FUS sonication. Conclusion: Although further research is needed-including longer follow-up LFP measurements after FUS sonication and the collection of more LFP dataneuromodulation with FUS can be considered usable in other neurological disease models.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in theta and gamma oscillations of the medial prefrontal cortex following hippocampal-focused ultrasound stimulation

Baek,

Seo,

Kim

et al. 2024

Neurofunction

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“…To our knowledge, no evidence pointed to a different recruitment of mPFC SR cells as early as after 1 day. However, it has been proposed that a possible way the prefrontal cortex increases stability is via the formation of ensembles of cells that are synchronously activated 36 , stabilizing neuronal activity and allowing memory recall via pattern completion 37 . Our results show the presence of synchronized ensembles both during training but also 1 day after, and are in line with Zelikowsky et al 38 findings, showing mPFC representation of both contextual and emotional aspects of memory.…”

Section: Discussionmentioning

confidence: 99%

Threat-dependent scaling of prelimbic dynamics to enhance fear representation

Casanova,

Pouget,

Treiber

et al. 2023

Preprint

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Promptly identifying threatening stimuli is crucial for survival. Freezing is a natural behavior displayed by rodents towards potential or actual threats. While it is known that the prelimbic cortex (PL) is involved in both risk evaluation and in fear and anxiety-like behavior expression, here we explored whether PL neuronal activity can dynamically represent different internal states of the same behavioral output. We found that freezing can always be decoded from PL activity at a population level. However, the sudden presentation of a fearful stimulus quickly reshaped PL to a new neuronal activity state, an effect not observed in other cortical or subcortical regions. This shift changed PL freezing representation and is necessary for fear memory expression. Our data reveal the unique role of PL in detecting threats and internally adjusting to distinguish between different freezing-related states.

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“…Most of these features are shared between the primate PFC and rodent mPFC. However, taking into account that rodent mPFC is agranular (layer IV is not present), the MD also projects to areas non-related to rodent mPFC ( Donoghue and Wise, 1982 ) and the differences of spatial arrangement between rodent and primate PFC (the rodent mPFC lies next to the allocortex) has led to the view that the primate and rodent PFC are not homologues, but these areas emerged differentially during evolution to accomplish class-common behavioral need, (i.e., the cognitive control of behavior) ( Carlén, 2017 ; Hanganu-Opatz et al, 2023 ). Also, through comparative studies of gene expression patterns, it has evidenced differences between homologous cortical areas in humans and rodents ( Bernard et al, 2012 ; Zeng et al, 2012 ).…”

Section: The Prefrontal Cortex and Cognitive Control Of Behaviormentioning

confidence: 99%

Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models

Negrón-Oyarzo,

Dib,

Chacana-Véliz

et al. 2024

Front. Neural Circuits

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Cognitive control of behavior is crucial for well-being, as allows subject to adapt to changing environments in a goal-directed way. Changes in cognitive control of behavior is observed during cognitive decline in elderly and in pathological mental conditions. Therefore, the recovery of cognitive control may provide a reliable preventive and therapeutic strategy. However, its neural basis is not completely understood. Cognitive control is supported by the prefrontal cortex, structure that integrates relevant information for the appropriate organization of behavior. At neurophysiological level, it is suggested that cognitive control is supported by local and large-scale synchronization of oscillatory activity patterns and neural spiking activity between the prefrontal cortex and distributed neural networks. In this review, we focus mainly on rodent models approaching the neuronal origin of these prefrontal patterns, and the cognitive and behavioral relevance of its coordination with distributed brain systems. We also examine the relationship between cognitive control and neural activity patterns in the prefrontal cortex, and its role in normal cognitive decline and pathological mental conditions. Finally, based on these body of evidence, we propose a common mechanism that may underlie the impaired cognitive control of behavior.

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Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective

Cited by 23 publications

References 219 publications

Changes in theta and gamma oscillations of the medial prefrontal cortex following hippocampal-focused ultrasound stimulation

Changes in theta and gamma oscillations of the medial prefrontal cortex following hippocampal-focused ultrasound stimulation

Threat-dependent scaling of prelimbic dynamics to enhance fear representation

Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models

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