Resolving Time and Space Constraints During Neural Crest Formation and Delamination

Duband, Jean‐Loup; Dady, Alwyn

doi:10.1016/bs.ctdb.2014.11.002

Cited by 27 publications

(31 citation statements)

References 120 publications

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“…Taken together, the preceding studies suggest that cadherin expression in the neural crest during delamination and EMT is quite dynamic and further underscore that EMT does not encompass a simple switch from one cadherin to another (Duband et al, 2015; Rogers et al, 2013; Shook and Keller, 2003; Taneyhill and Schiffmacher, 2013; Theveneau and Mayor, 2012a, b). For instance, the repertoire of cadherins expressed in chick midbrain premigratory neural crest cells changes dramatically, both prior to and during EMT.…”

Section: B Cadherin Function In Neural Crest Cell Ontogenymentioning

confidence: 73%

“…As a pseudo-stratified epithelium, the neural tube (and premigratory neural crest cells) possesses specific junctional complexes to maintain this epithelial state. These include both tight and adherens junctions ((Fishwick et al, 2012; Wu et al, 2011); reviewed in (Duband et al., 2015; Taneyhill and Schiffmacher, 2013)), along with the appropriate intracellular molecules, such as Rho family GTPases, that render these cells immotile (reviewed in (Kalcheim, 2015; Taneyhill and Padmanabhan, 2013)).…”

Section: A Formation Of the Neural Crestmentioning

confidence: 99%

“…The timing of the experiments during chick development (3–8 hours post-electroporation in (Coles et al, 2007), just prior to delamination/EMT, versus 20–24 hours post-electroporation in (Park and Gumbiner, 2010), well before EMT when neural crest cells are being specified), however, may help reconcile the two experiments by suggesting distinct functions for Cadherin-6B during neural crest cell specification and later during delamination/EMT (Duband et al, 2015). Given that the first group perturbed Cadherin-6B expression right before the onset of EMT in the chick head, the de-epithelialization and reduction in adhesion between premigratory neural crest cells may have already occurred.…”

Section: B Cadherin Function In Neural Crest Cell Ontogenymentioning

confidence: 99%

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Should I stay or should I go? Cadherin function and regulation in the neural crest

Taneyhill

Schiffmacher

2017

Genesis

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Our increasing comprehension of neural crest cell development has reciprocally advanced our understanding of cadherin expression, regulation, and function. As a transient population of multipotent stem cells that significantly contribute to the vertebrate body plan, neural crest cells undergo a variety of transformative processes and exhibit many cellular behaviors, including epithelial-to-mesenchymal-transition (EMT), motility, collective cell migration, and differentiation. Multiple studies have elucidated regulatory and mechanistic details of specific cadherins during neural crest cell development in a highly contextual manner. Collectively, these results reveal that gradual changes within neural crest cells are accompanied by often times subtle, yet important, alterations in cadherin expression and function. The primary focus of this review is to coalesce recent data on cadherins in neural crest cells, from their specification to their emergence as motile cells soon after EMT, and to highlight the complexities of cadherin expression beyond our current perceptions, including the hypothesis that the neural crest EMT is a transition involving a predominantly singular cadherin switch. Further advancements in genetic approaches and molecular techniques will provide greater opportunities to integrate data from various model systems in order to distinguish unique or overlapping functions of cadherins expressed at any point throughout the ontogeny of the neural crest.

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Section: B Cadherin Function In Neural Crest Cell Ontogenymentioning

confidence: 73%

Section: A Formation Of the Neural Crestmentioning

confidence: 99%

Section: B Cadherin Function In Neural Crest Cell Ontogenymentioning

confidence: 99%

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Should I stay or should I go? Cadherin function and regulation in the neural crest

Taneyhill

Schiffmacher

2017

Genesis

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“…Although we have yet to discover all of these controls, the development of one cell type in particular, neural crest (NC) cells, has been studied at length. Ectodermal cells respond to many instructive signals very early in development to form neural tissue (Gaur et al, 2016; Lamb et al, 1993; Rogers, Archer, Cunningham, Grammer, & Casey, 2008), epidermal/placodal tissue (Nordin & LaBonne, 2014; Schlosser, 2014), or NC tissue (Duband, Dady, & Fleury, 2015). The epigenetic and molecular specification of each of these tissue-types is followed by morphogenetic events such as neural tube closure and NC cell migration.…”

Section: | Introductionmentioning

confidence: 99%

Specifying neural crest cells: From chromatin to morphogens and factors in between

Rogers

Nie

2018

WIREs Developmental Biology

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Neural crest (NC) cells are a stem-like multipotent population of progenitor cells that are present in vertebrate embryos, traveling to various regions in the developing organism. Known as the "fourth germ layer", these cells originate in the ectoderm between the neural plate (NP), which will become the brain and spinal cord, and nonneural tissues that will become the skin and the sensory organs. NC cells can differentiate into more than 30 different derivatives in response to the appropriate signals including, but not limited to, craniofacial bone and cartilage, sensory nerves and ganglia, pigment cells, and connective tissue. The molecular and cellular mechanisms that control the induction and specification of NC cells include epigenetic control, multiple interactive and redundant transcriptional pathways, secreted signaling molecules, and adhesion molecules. NC cells are important not only because they transform into a wide variety of tissue types, but also because their ability to detach from their epithelial neighbors and migrate throughout developing embryos utilizes mechanisms similar to those used by metastatic cancer cells. In this review, we discuss the mechanisms required for the induction and specification of NC cells in various vertebrate species, focusing on the roles of early morphogenesis, cell adhesion, signaling from adjacent tissues, and the massive transcriptional network that controls the formation of these amazing cells. This article is categorized under: Nervous System Development > Vertebrates: General Principles Gene Expression and Transcriptional Hierarchies > Regulatory Mechanisms Gene Expression and Transcriptional Hierarchies > Gene Networks and Genomics Signaling Pathways > Cell Fate Signaling.

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“…In any case, the critical developmental role for such molecules depends upon their ability to mediate homo-or heterophilic interactions. For example, in the earliest developmental stages, strong homophilic calciumdependent cell interactions involving the function of Cadherin family components contribute to the control of events of key ontogenetic relevance such as germ layer separation (Stepniak et al, 2009;Hirano and Takeichi, 2012;McKeown et al, 2013;Barriga and Mayor, 2015;Hayashi and Takeichi, 2015;Duband et al, 2015). However, it is also worth mentioning that members of the same family may mediate the control of later developmental events as neurite growth (Gartner et al, 2012;Hayashi et al, 2014;Stoeckli, 2014).…”

Section: Families Of Morphoregulatory Moleculesmentioning

confidence: 99%

The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders

Gennarini

Bizzoca

Picocci

et al. 2017

Molecular and Cellular Neuroscience

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Resolving Time and Space Constraints During Neural Crest Formation and Delamination

Cited by 27 publications

References 120 publications

Should I stay or should I go? Cadherin function and regulation in the neural crest

Should I stay or should I go? Cadherin function and regulation in the neural crest

Specifying neural crest cells: From chromatin to morphogens and factors in between

The role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders

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