Resonance behaviors of encapsulated microbubbles oscillating nonlinearly with ultrasonic excitation

Qin, Dui; Lei, Shuang; Wang, Xia; Zhong, Xianhua; Ji, Xiaojuan; Li, Zhangyong

doi:10.1016/j.ultsonch.2023.106334

Cited by 14 publications

(3 citation statements)

References 57 publications

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“…This phenomenon could potentially be attributed to the proximity of larger initial bubbles to the resonant radius within the examined parameters. Notably, previous studies [26][27][28] have demonstrated that the maximum expansion ratio is achieved when bubbles are driven under resonant conditions. The oscillation of the bubble radii can be roughly divided into three periods: expansion, collapse, and rebound.…”

Section: Factors Influencing the Instability Characteristics Of Two N...mentioning

confidence: 97%

Shape and diffusion instabilities of two non-spherical gas bubbles under ultrasonic conditions

Bao 包,

Wang 王

2024

Chinese Phys. B

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Ultrasonic cavitation involves dynamic oscillation processes induced by small bubbles in a liquid under the influence of ultrasonic waves. This study focuses on the investigation of shape and diffusion instabilities in two bubbles formed during cavitation. The derived equations for two non-spherical gas bubbles, based on Perturbation theory and the Bernoulli equation, enable the analysis of their shape instability. Numerical simulations, utilizing the modified Keller-Miksis equation, are performed to examine the shape and diffusion instabilities. Three types of shape instabilities, namely Rayleigh-Taylor, Rebound, and parametric instabilities, are observed. The results highlight the influence of initial radius, distance, and perturbation parameter on the shape and diffusion instabilities, as evidenced by the R 0-Pa phase diagram and the variation pattern of the equilibrium curve. This research contributes to the understanding of multiple bubble instability characteristics, which has important theoretical implications for future studies in the field. Specifically, it underscores the significance of initial bubble parameters, driving pressure, and relative gas concentration in determining the shape and diffusive equilibrium instabilities of non-spherical bubbles.

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Section: Factors Influencing the Instability Characteristics Of Two N...mentioning

confidence: 97%

Shape and diffusion instabilities of two non-spherical gas bubbles under ultrasonic conditions

Bao 包,

Wang 王

2024

Chinese Phys. B

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“…For the larger bubble 2, the main resonance peak is generated at a much smaller frequency, probably due to the inverse dependence of resonance frequency on the bubble size [50] , [51] . Moreover, subharmonic resonances of the bubble 2 are also obtained as marked by the red arrows, which are consistent with the results shown in Fig.…”

Section: Interaction Effects Of Two Bubbles Under Dual-frequency Drivingmentioning

confidence: 99%

Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system

Qin,

Yang,

Lei

et al. 2023

Ultrasonics Sonochemistry

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“…The type of lipid used allows the shell to buckle during compression or rupture during expansion, which increases the generation of harmonics. , Comparisons between theoretical simulations and experimental MB dynamic responses corroborate the observation that both MB shell composition and microstructure directly impact MB rheological properties, which are the main drivers of MB dynamic response, including oscillation amplitudes and resonant radii at harmonic and subharmonic resonances. Increasing shell stiffness and viscosity dampens MB oscillation amplitude, while a reduction in interfacial tension at the PFC–water interface that decreases shell viscosity and stiffness increases MB oscillation amplitude. − Because cross-linking shell lipids decreases or eliminates MB nonlinear response to ultrasound, most likely by restricting MB oscillation, utilizing cross-linkers that are cleavable by chemical, enzymatic, or other stimuli generates harmonics allowing detection of these bioresponsive MBs. − The successful demonstration of these approaches has paved the way to providing biomarker-responsive ultrasound contrast agents.…”

mentioning

confidence: 99%

Modulating Nonlinear Acoustic Response of Phospholipid-Coated Microbubbles with pH for Ultrasound Imaging

Ali,

de Gracia Lux,

Brown

et al. 2024

ACS Sens.

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Activatable microbubble contrast agents for contrast-enhanced ultrasound have a potential role for measuring physiologic and pathologic states in deep tissues, including tumor acidosis. In this study, we describe a novel observation of increased harmonic oscillation of phosphatidylcholine microbubbles (PC-MBs) in response to lower ambient pH using a clinical ultrasound scanner. MB echogenicity and nonlinear echoes were monitored at neutral and acidic pH using B-mode and Cadence contrast pulse sequencing (CPS), a harmonic imaging technique at 7.0 and 1.5 MHz. A 3-fold increase in harmonic signal intensity was observed when the pH of PC-MB suspensions was decreased from 7.4 to 5.5 to mimic normal and pathophysiological levels that can be encountered in vivo. This pH-mediated activation is tunable based on the chemical structure and length of phospholipids composing the MB shell. It is also reliant on the presence of phosphate groups, as the use of lipids without phosphate instead of phospholipids completely abrogated this phenomenon. The increased harmonic signal likely is the result of increased MB oscillation caused by a decrease of the interfacial tension induced at a lower pH, altering the lipid conformation. While relative signal changes are interpreted clinically as mostly related to blood flow, pH effects could be significant contributors, particularly when imaging tumors. While our observation can be used clinically, it requires further research to isolate the effect of pH from other variables. These findings could pave the way toward for the development of new smart ultrasound contrast agents that expand the clinical utility of contrastenhanced ultrasound.

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Resonance behaviors of encapsulated microbubbles oscillating nonlinearly with ultrasonic excitation

Cited by 14 publications

References 57 publications

Shape and diffusion instabilities of two non-spherical gas bubbles under ultrasonic conditions

Shape and diffusion instabilities of two non-spherical gas bubbles under ultrasonic conditions

Investigation of interaction effects on dual-frequency driven cavitation dynamics in a two-bubble system

Modulating Nonlinear Acoustic Response of Phospholipid-Coated Microbubbles with pH for Ultrasound Imaging

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