2020
DOI: 10.3390/molecules25194386
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Resonance Raman Optical Activity Spectroscopy in Probing Structural Changes Invisible to Circular Dichroism Spectroscopy: A Study on Truncated Vitamin B12 Derivatives

Abstract: This work demonstrates resonance Raman optical activity (RROA) spectra of three truncated vitamin B12 derivatives modified within the nucleotide loop. Since truncated cobalamins possess sufficiently high rotational strength in the range of ROA excitation (532 nm), it was possible to record their spectra in the resonance condition. They showed several distinct spectral features allowing for the distinguishing of studied compounds, in contrast to other methods, i.e., UV-Vis absorption, electronic circular dichro… Show more

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Cited by 8 publications
(12 citation statements)
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“…Formation of 1 was confirmed also by changes in the infrared spectrum (pink line in Figure 3 ), occurring in the range characteristic for the stretching Co–C vibrations [ 34 ], namely the shifts from 496 cm −1 to 515 cm −1 .…”
Section: Resultsmentioning
confidence: 85%
“…Formation of 1 was confirmed also by changes in the infrared spectrum (pink line in Figure 3 ), occurring in the range characteristic for the stretching Co–C vibrations [ 34 ], namely the shifts from 496 cm −1 to 515 cm −1 .…”
Section: Resultsmentioning
confidence: 85%
“…see Figure 1). Accumulated resonance Raman spectra of cobalamines (vitamin B 12 derivatives) all indicate that the corrin-ring frequencies are surprisingly similar no matter what the axial ligand 27,31,32,39 or the oxidation state 27,30 of the cobalt atom (Co(II) or Co(III)) is. Close inspection of the spectra, however, reveals that the relative intensities of some minor bands differ substantially among cobalamines.…”
Section: Discussionmentioning
confidence: 99%
“…RROA can be detected at low concentrations (ca. 10 −5 M) [19–22] while maintaining structural sensitivity [12, 21, 23] . Single state resonance usually leads to single signed RROA, [1, 19, 24] whereas pre‐resonance and more resonance states provide RROA spectrum with positive and negative bands, similarly as for the “conventional” non‐resonance case.…”
Section: Figurementioning
confidence: 99%
“…Single state resonance usually leads to single signed RROA, [1, 19, 24] whereas pre‐resonance and more resonance states provide RROA spectrum with positive and negative bands, similarly as for the “conventional” non‐resonance case. However, up to now there is a limited number of reports on RROA, due to the challenges arising during the measurement, including artifacts related to absorption and fluorescence [12–14, 21, 23, 25] …”
Section: Figurementioning
confidence: 99%