Resonance Rayleigh scattering spectra for studying the interaction of aminoglycoside antibiotics with pontamine sky blue and their analytical applications

Hu, Xiaoli; Liu, Shaopu P.; Li, Nianbing

doi:10.1007/s00216-003-1878-1

Cited by 33 publications

(16 citation statements)

References 16 publications

(11 reference statements)

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“…[24][25][26][27][28] In this work, we found that in a weak acid aqueous solution, the RRS for Sild alone as an organic cation or Evans Blue (EB), itself, as an organic anion was weak. However, when two agents reacted with each other to form ion-association complexes by virtue of electrostatic and hydrophobic interaction forces, the RRS intensity could be greatly enhanced and a new RRS spectrum was observed.…”

Section: 3mentioning

confidence: 99%

Resonance Rayleigh-Scattering Method for the Determination of Sildenafil Citrate in a Pharmaceutical Formulation Using Evans Blue

Liu¹,

Fan²,

Hu³

et al. 2006

ANAL. SCI.

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Sildenafil citrate is a potent and selective inhibitor of cGMP (type V)-specific phosphodiesterase capable of enhancing relaxation of the penile corpus cavernosum, and therefore having the potential to improve penile erectile function. 1 The activity of Sild is as an efficacious, orally active agent for the treatment of male erectile dysfunction, and is thus so currently being applied widely to clinical treatments. 2,3At present, most of the methods for the determination of Sild are based on HPLC, 4-9 and electrochemistry. 10,11 However, the procedures for many methods are not simple due to a preseparation required frequently before determining Sild; also, the sensitivity of some methods is not high enough. Dinesh et al. 12 reported an extractive spectrophotometric method for the determination of Sild with acid triphenylmethane dyes. The sensitivity of this method was insufficient and double extraction was required. Thus, further developing a highly sensitive, simple and rapid method for the determination of Sild is important.In recent years, resonance Rayleigh scattering (RRS) as a new analytical technique has been applied to investigate and determine some inorganic ions [13][14][15] and biological macromolecules, such as nucleic acid, 16-18 protein, 19-21 heparin 22,23 and medicines. [24][25][26][27][28] In this work, we found that in a weak acid aqueous solution, the RRS for Sild alone as an organic cation or Evans Blue (EB), itself, as an organic anion was weak. However, when two agents reacted with each other to form ion-association complexes by virtue of electrostatic and hydrophobic interaction forces, the RRS intensity could be greatly enhanced and a new RRS spectrum was observed. The intensity of RRS was directly proportional to the concentration of Sild in the range 0 -11.5 μg ml -1 . The method had high sensitivity and the detection limit for the sild was 30.3 ng ml -1 . In the present work, the spectral characteristics of RRS, the influence of various factors, optimum conditions of interaction, and the properties of analytical chemistry were investigated. A new method for the determination of Sild in a pharmaceutical formulation based on the RRS of the ion-association complex has been developed. Furthermore, the interaction mechanism was considered. Experimental Apparatus and reagentsA Shimadzu RF-540 Fluorospectrophotometer (Kyoto, Japan) was used for recording the RRS spectrum. A UV-VIS 8500 spectrophotometer (Tianmei Co., Shanghai, China) was used for recording the absorption spectrum. A pHs-3C acidimeter (Shanghai Dazhong Analytical Instrumental Plant, China) was used for adjusting of the pH value.A 1.0 × 10 -3 mol l -1 stock solution of Sild (offered by West China College of Medicine, Sichuan University, purity 99.9%) was prepared using water and the dilution was made to the 66.6 μg ml -1 working solution. EB (Fluka Co., Switzerland) aqueous A highly sensitive resonance Rayleigh-scattering (RRS) method for the determination of sildenafil citrate has been developed, based on the fact that sild...

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Section: 3mentioning

confidence: 99%

Resonance Rayleigh-Scattering Method for the Determination of Sildenafil Citrate in a Pharmaceutical Formulation Using Evans Blue

Liu¹,

Fan²,

Hu³

et al. 2006

ANAL. SCI.

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“…Since its first introduction to the study of the aggregation of porphyrins, using a conventional spectrofluorometer (8,9), the RLS technique has become a useful technique for the determination of biological macromolecules such as nucleic acids (10)(11)(12) and proteins (13)(14)(15). Moreover, this method has been used for the study and determination of drugs (16)(17)(18), inorganic ions (19)(20)(21) and surfactants (22). Among the RLS methods for determining drugs, most are based on the interaction of drugs with an RLS probe.…”

Section: Introductionmentioning

confidence: 99%

Resonance light scattering study on the interaction of benproperine phosphate with eriochrome blue black R in the presence of sodium dodecylbenzene sulphonate and its analytical application

et al. 2008

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The interaction of benproperine phosphate (BPP) with eriochrome blue black R (EBBR) in the presence of sodium dodecylbenzene sulphonate (SDBS) was studied using resonance light scattering (RLS) technology and ultraviolet-visual (UV-vis) spectrophotometry. Under optimum conditions, BPP reacts with EBBP and SDBS to form a three-component complex, which results in strong RLS signal and a new RLS peak. The enhanced RLS intensities are proportional to the concentration of BPP over the range 0.6-28.0 microg/mL, with a detection limit of 0.053 microg/mL. The affecting factors as well as the influence of coexisting substances were investigated. The results indicate that this assay method could be applied to the determination of BPP in pharmaceuticals, serum and urine samples with satisfactory results.

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“…In recent years, a RS spectral method for the determination of antibiotics at the level of 12.9-17.6 ng/mL has been reported (19), based on simple molecular interactions; the selectivity is not good. To improve the sensitivity and selectivity, we have coupled the complex reaction (20) and catalytic reaction (21) with a RS spectral method, with good results.…”

Section: Introductionmentioning

confidence: 99%

A sensitive and selective immuno‐nanogold resonance‐scattering spectral method for the determination of trace penicillin G

Jiang

Qin

2008

Luminescence

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A sensitive and selective immuno-nanogold resonance scattering spectral assay was developed for the determination of trace hapten penicillin G, based on the resonance scattering (RS) effect of the nanogold at 560 nm, and the nanogold-labelled immunoreaction took place in pH 5.4 phosphate citric acid buffer solutions and in the presence of polythylene glycol (PEG). The nanogold-labelled immunocomplex formed more and more with addition of penicillin G. The enhanced RS intensity at 560 nm Delta I(RS) was linear to the penicillin G concentration in the range 7.5-1700 ng/mL, with a detection limit of 0.78 ng/mL. The results indicate that the immunonanogold-labelled RS spectral assay has a high specificity and sensitivity for quantitative determination of penicillin G in raw milk samples.

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Resonance Rayleigh scattering spectra for studying the interaction of aminoglycoside antibiotics with pontamine sky blue and their analytical applications

Cited by 33 publications

References 16 publications

Resonance Rayleigh-Scattering Method for the Determination of Sildenafil Citrate in a Pharmaceutical Formulation Using Evans Blue

Resonance Rayleigh-Scattering Method for the Determination of Sildenafil Citrate in a Pharmaceutical Formulation Using Evans Blue

Resonance light scattering study on the interaction of benproperine phosphate with eriochrome blue black R in the presence of sodium dodecylbenzene sulphonate and its analytical application

A sensitive and selective immuno‐nanogold resonance‐scattering spectral method for the determination of trace penicillin G

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