Resonant cantilever sensors operated in a high-Q in-plane mode for real-time bio/chemical detection in liquids

Tao, Yihan; Li, Xinxin; Xu, Tingting; Yu, Haitao; Xu, Pengcheng; Xiong, Bin; Wei, Changzheng

doi:10.1016/j.snb.2011.05.030

Cited by 64 publications

(39 citation statements)

References 21 publications

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“…Toxic metal ions. Pollution containing heavy metals, especially Hg 2+ , is a serious environmental problem [55][56][57] and the detection of its traces in wastewater is thus of substantial demand. [58][59] Compared with conventional detection methods, [60][61][62] such as colorimetric assay, cold-vapor atomic absorption spectrometry (AAS), and inductively coupled plasma spectroscopy (ICP), etc., QCM-based sensors are more desirable because they are portable enough for on-site monitoring of heavy metal ions in the real environment.…”

Section: Silica-based Mesoporous Materialsmentioning

confidence: 99%

Advanced Nanoporous Material–Based QCM Devices: A New Horizon of Interfacial Mass Sensing Technology

Torad

Zhang

Amer

et al. 2019

Adv Materials Inter

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This review introduces an overview of recent advancements in the fabrication of QCM sensing devices for the interfacial mass sensing of targeted chemical vapors and ions through combination with nanoporous materials including mesoporous materials (e.g., silica, metal oxide and metal), carbon-based nanomaterials (e.g., graphene and carbon nanotube), metal-organic frameworks (MOFs), MOF-derived nanoporous carbons, Prussian blue and its analogues (PB and PBA), zeolites and related materials.

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Section: Silica-based Mesoporous Materialsmentioning

confidence: 99%

Advanced Nanoporous Material–Based QCM Devices: A New Horizon of Interfacial Mass Sensing Technology

Torad

Zhang

Amer

et al. 2019

Adv Materials Inter

View full text Add to dashboard Cite

show abstract

“…Significant efforts have been made to improve their quality factor in liquid. Solutions include using larger cantilevers operated at high order resonant modes [5], using in-plane resonant modes [6], [7], implementing feedback loops [8], or incorporating a microchannel in the cantilever [9]. Using higher order or in-plane resonant modes is challenging because it is difficult to excite these modes due to the increased effective stiffness of the cantilever [10].…”

Section: Introductionmentioning

confidence: 99%

Doubling the quality factor of cantilevers in liquid through fluid coupling-based actuation

Leahy

Lai

2018

Journal of Applied Physics

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Dynamic-mode cantilevers are a promising tool for real-time biosensing applications due to their high sensitivity and ability to perform label-free measurements. However, operating dynamic-mode cantilevers in liquid is challenging since viscous damping greatly reduces their quality factor and thus limit of detection. We reasoned through physical analysis that if the motion of the surrounding fluid is driven by an external force and not by the sensing cantilever itself, then the dissipative fluid force on the cantilever could be reduced and the quality factor of the cantilever could be increased. Here we demonstrate a new fluid coupling-based actuation method where one piezoelectric cantilever (directly excited) is used to excite another closely located cantilever (indirectly excited) through vibrations transferred through the surrounding medium. We performed measurements in several mediums, including air, water, ethanol, and acetone and observed that the viscosity of the medium influences the effectiveness of fluid coupling-based actuation. We also observed that fluid coupling-based actuation is more effective for the first bending mode of the cantilever, likely since fluid motion decays with distance from the tip of the directly excited cantilever. A significant result is that the indirectly excited cantilever has a quality factor that is double that of the directly excited one for the first bending mode in water. This method could improve the performance of dynamic-mode cantilevers operated in liquid.

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“…11 Therefore, other techniques have been developed to increase sensitivity. These include using a resonant frequency tracking circuit 12,13 using the higher order resonant modes of a millimeter-sized cantilever, [14][15][16][17][18][19][20] or integrating a suspended microchannel into a cantilever. 21,22 These techniques have provided sensitivities high enough for measuring a single bacterium.…”

Section: Introductionmentioning

confidence: 99%

A gap method for increasing the sensitivity of cantilever biosensors

Leahy

Lai

2017

Journal of Applied Physics

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Dynamic-mode cantilever biosensors are an attractive technology for biological sensing. However, researchers are constantly seeking ways to increase their sensitivity, especially in liquids, in order to rapidly detect biological particles in dilute samples. Here, we investigate a novel gap method for increasing their sensitivity. We design cantilevers with a micron-sized gap between their free end and a supporting structure that constrains the motion of individual particles deposited across the gap. When individual particles are deposited across the gap, they form a bridge between the free end of the cantilever and the supporting structure and generate fundamental resonant frequency shifts that are two orders of magnitude higher than when they are deposited on conventional cantilevers. Through experiments and simulation in air, we show that cantilevers based on the gap method rely on stiffness-change instead of mass-change, and that they are significantly more sensitive than conventional cantilevers.

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Resonant cantilever sensors operated in a high-Q in-plane mode for real-time bio/chemical detection in liquids

Cited by 64 publications

References 21 publications

Advanced Nanoporous Material–Based QCM Devices: A New Horizon of Interfacial Mass Sensing Technology

Advanced Nanoporous Material–Based QCM Devices: A New Horizon of Interfacial Mass Sensing Technology

Doubling the quality factor of cantilevers in liquid through fluid coupling-based actuation

A gap method for increasing the sensitivity of cantilever biosensors

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