“…Regarding force sensors, for manipulating nano particles, biomolecular or cells, development of high sensitivity force sensors with mechanical types [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ], electrical types [ 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ], and optical types [ 65 , 66 , 67 , 68 ], it has been a great challenge for advanced micro/nano-assembly and bio-engineering. Willemsen et al [ 49 ] summarized the works of the detection of biomolecular interaction forces using AFM with silicon nitride probes by that time, in which the AFM probes were considered as force sensors that could detect the interaction forces between individual molecules in nN (10 −9 N) range by mechanical evaluations, such as strain change or frequency shift.…”