Resonant scattering-enhanced photothermal microscopy

Li, Qiang; Shi, Zhonghong; Wu, Lijun; Wei, Hong

doi:10.1039/c9nr10893a

Cited by 8 publications

(9 citation statements)

References 31 publications

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“…The strong light scattering from SPR has received an extraordinary attention due to the useful applications in photodetectors, cell and biomedical imaging etc. [1][2][3][4][5][6][7][8][9]. However, both light absorption and scattering are all resulted from SPR, thus they have similar resonance wavelength.…”

Section: Introductionmentioning

confidence: 99%

Improve the Effective Resonance Light Scattering of Three-Layered Plasmonic Au@Dielectric@Ag Bimetallic Nanoshells

Zhu

Zhao

2021

Plasmonics

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The strong light scattering from SPR has received an extraordinary attention due to the useful applications in photodetectors, cell and biomedical imaging. However, the applications using light scattering require a high scattering cross-section along with low absorption losses near the resonance wavelength. In this paper, effective plasmonic scattering of three-layered Au-Ag bimetallic nanoshells with a dielectric separate layer has been studied using the quasi-static approximation of classical electrodynamics. Because of the surface plasmon resonance (SPR)-induced intense light absorption, the effective scattering intensity is much weaker than that of scattering cross section. However, the effective scattering intensity could be improved by tuning the geometric dimension and local dielectric environment of the nanostructure. It has been found that the greatest effective scattering takes place when the outer Ag nanoshell has a thick thickness or the dielectric separate layer has a small dielectric constant. The effective scattering also depends on the inner Au sphere radius and outer surrounding dielectric constant. Because of the mode transformation of the SPR, the effective scattering could also be greatly improved when the inner Au sphere has a very small or large size. However, the effective scattering intensity changes non-monotonously as the surrounding dielectric constant increases. The greatest effective scattering could be obtained when the surrounding dielectric constant has an intermediate value. This tunable effective plasmonic scattering of Au@Ag three-layered nanoshells presents a potential for design and fabrication of plasmonic optical nanodevice based on resonance light scattering.

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Section: Introductionmentioning

confidence: 99%

Improve the Effective Resonance Light Scattering of Three-Layered Plasmonic Au@Dielectric@Ag Bimetallic Nanoshells

Zhu

Zhao

2021

Plasmonics

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“…The reader interested in TLM application in single molecule imaging is encouraged to take a look at the review of the TLM techniques by Adhikari et al [82]. One of the most recent advances that has attracted much attention is a TLM that takes into account the scattering from nano-objects [83,84]. Figure 6 presents the setup built by Li et al [84], which they used in the studies of Ag nanowires (Ag NW) dissolved in glycerol.…”

Section: Advances In Tlm and Tlsmentioning

confidence: 99%

“…One of the most recent advances that has attracted much attention is a TLM that takes into account the scattering from nano-objects [83,84]. Figure 6 presents the setup built by Li et al [84], which they used in the studies of Ag nanowires (Ag NW) dissolved in glycerol. It consisted of typical components of a TLM (and TLS as well): the function generator that provides the signal to the acousto-optic modulator that modulates the HL beam; the microscope objective that focuses the HL beam at the sample; the same objective collects the probe beam light reflected/scattered from the sample; the avalanche photodiode that detects the small reflected/scattered signal; the lock-in-amplifier that denoises the collected signal using as the reference the modulation signal from the function generator.…”

Section: Advances In Tlm and Tlsmentioning

confidence: 99%

Thermal lensing: outside of the lasing medium

Dobek

2022

Appl. Phys. B

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The thermal lens formed in a thermo-optical material as a result of its inhomogeneous heating, is a well-known phenomenon that has found widespread interest in the last decades, especially in the field of laser engineering and photo-thermal spectroscopy. In recent years, growing interest in the application of thermal lensing in different fields of optics and material studies has been observed. This review summarizes the latest efforts made by the scientific community to develop ways of using the phenomenon of thermal lensing. Its applications in spectroscopy, in laser beam formation and in imaging are described. The advantages and disadvantages of the thermal lensing in regard to these areas along with the potential future applications of the phenomenon are discussed.

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“… 95 Li et al developed a resonant scattering-enhanced PTM approach in which the imaged nano-objects were nearly resonant with the probe laser light. 96 This allowed resonant scattering enhanced PT imaging of plasmonic NPs with ultra-high sensitivity.…”

Section: Imaging Techniquesmentioning

confidence: 99%

Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles

Friedrich¹,

Kappes²,

Cicha³

et al. 2022

IJN

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Label-free detection of nanoparticles is essential for a thorough evaluation of their cellular effects. In particular, nanoparticles intended for medical applications must be carefully analyzed in terms of their interactions with cells, tissues, and organs. Since the labeling causes a strong change in the physicochemical properties and thus also alters the interactions of the particles with the surrounding tissue, the use of fluorescently labeled particles is inadequate to characterize the effects of unlabeled particles. Further, labeling may affect cellular uptake and biocompatibility of nanoparticles. Thus, label-free techniques have been recently developed and implemented to ensure a reliable characterization of nanoparticles. This review provides an overview of frequently used label-free visualization techniques and highlights recent studies on the development and usage of microscopy systems based on reflectance, darkfield, differential interference contrast, optical coherence, photothermal, holographic, photoacoustic, total internal reflection, surface plasmon resonance, Rayleigh light scattering, hyperspectral and reflectance structured illumination imaging. Using these imaging modalities, there is a strong enhancement in the reliability of experiments concerning cellular uptake and biocompatibility of nanoparticles, which is crucial for preclinical evaluations and future medical applications.

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Resonant scattering-enhanced photothermal microscopy

Abstract: We have developed a novel strategy of resonant scattering-enhanced photothermal microscopy, where the imaged nanoparticles are near-resonant with the probe light.

Cited by 8 publications

References 31 publications

Improve the Effective Resonance Light Scattering of Three-Layered Plasmonic Au@Dielectric@Ag Bimetallic Nanoshells

Improve the Effective Resonance Light Scattering of Three-Layered Plasmonic Au@Dielectric@Ag Bimetallic Nanoshells

Thermal lensing: outside of the lasing medium

Optical Microscopy Systems for the Detection of Unlabeled Nanoparticles

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