Multispectral sensors such as Ambient Light sensors (ALS) are becoming increasingly popular due to growing concerns for health, environment, and safety. These sensors provide non-intrusive quantitative and qualitative information on the photonic footprints of interest. To meet the demand for mass production, CMOS image sensors (CIS) are a good basis for these devices. Commercial hyperspectral cameras use a generalization of Bayer-like matrix of Fabry-Perot cavities (FPC) as multispectral filters embedded onto a CIS. However, the delicate fabrication of these filters is tedious and leads to a pronounced surface topology. In this study, we demonstrate experimentally that multispectral sensing can be achieved using a hybrid FPC (h-FPC) which is an improved version of the regular FP cavity, that consists of two silicon mirrors, SiO2 spacer, and a sub-wavelength silicon grating at the center of the cavity. These structures were fabricated using a CMOS compatible process and can be integrated into an imager process flow. The h-FPC optical response can be tuned in the near-infrared region (750-950nm) by changing the filling factor of the grating inside the cavity without varying its height, unlike planar FPC. This feature makes the hybrid FPC a more versatile and efficient option for agile multispectral sensing.